Junne, S. B. et al. published their research in E-Journal of Chemistry in 2010 | CAS: 20776-54-9

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 2-Amino-4-iodobenzoic acid

Synthesis, characterization and antibacterial activity of some halo substituted Schiff bases was written by Junne, S. B.;Kadam, Archana B.;Shinde, S. L.;Waghamare, G. S.;Vibhute, Y. B.. And the article was included in E-Journal of Chemistry in 2010.Recommanded Product: 2-Amino-4-iodobenzoic acid This article mentions the following:

Halo substituted Schiff bases were designed and the synthesis of the target compounds was achieved using aryl amines and aryl aldehydes as starting materials and the products thus obtained were confirmed by IR and NMR. Example compounds thus prepared included 4-amino-2-nitro-N-[(3,4,5-trimethoxyphenyl)methylene]benzenamine, 2-bromo-4-[[(5-bromo-2-pyridinyl)imino]methyl]-6-methoxyphenol, etc. These compounds were screened against pathogenic bacteria by an agar diffusion method (Dermatophilus congolensis, Gram-pos., Mud fever, Staphylococcus aureus, Corynebacterium parvum, acne, Actinomyces bovis). In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Recommanded Product: 2-Amino-4-iodobenzoic acid).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 2-Amino-4-iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Levesque, Patrick et al. published their research in Journal of Organic Chemistry in 2010 | CAS: 20776-54-9

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C7H6INO2

Synthesis of Substituted Indole from 2-Aminobenzaldehyde through [1,2]-Aryl Shift was written by Levesque, Patrick;Fournier, Pierre-Andre. And the article was included in Journal of Organic Chemistry in 2010.Synthetic Route of C7H6INO2 This article mentions the following:

A mild, efficient, and simple method for the synthesis of 3-ethoxycarbonylindoles has been developed. Addition of Et diazoacetate (EDA) to 2-aminobenzaldehydes cleanly affords the indole core. E.g., addition of Et diazoacetate to 2-(benzylamino)-6-fluorobenzaldehyde (I) in presence of BF3.OEt2 gave 85% Et 1-benzyl-4-fluoroindole-3-carboxylate (II). As opposed to other common approaches for the synthesis of indole, this method displays both excellent functional group tolerance and perfect regiochem. control. This allowed the synthesis of a variety of useful indole building blocks from 2-aminobenzaldehydes derived from readily available anthranilic acids. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Synthetic Route of C7H6INO2).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C7H6INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Muathen, Hussni A. et al. published their research in Journal of Chemical Research, Synopses in 1994 | CAS: 20776-54-9

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 20776-54-9

Mild and efficient iodination of aromatic compounds with pyridine-iodine monochloride complex (PylCl) was written by Muathen, Hussni A.. And the article was included in Journal of Chemical Research, Synopses in 1994.Product Details of 20776-54-9 This article mentions the following:

A wide range of aromatic compounds (e.g., C6H6) have been effectively iodinated with a pyridine-iodine monochloride complex (I). Condensed polycyclic iodides, which are not readily obtained via direct iodination, can be prepared indirectly via their corresponding organomercurials in 1 step. Some benzoid and nonbenzoid heterocycles (e.g., indole) are iodinated with I. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Product Details of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

S-21 News Share a compound : 20776-54-9

Statistics shows that 2-Amino-4-iodobenzoic acid is playing an increasingly important role. we look forward to future research findings about 20776-54-9.

20776-54-9, Name is 2-Amino-4-iodobenzoic acid, 20776-54-9, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

[00313] Step A: To a solution of 2-amino-4-iodobenzoic acid (2.5 g, 9.50 mmol) in DMF (10 mL) at rt under argon were added EDCI (2.18 g, 11.40 mmol), 1 – hydroxybenzotriazole (1.54 g, 11.40 mmol), DIEA (1.98 mL, 11.40 mmol), and ammonia (7.0 N solution in MeOH; 1.90 mL, 13.30 mmol). The dark solution was stirred at rt overnight and diluted with H2O until precipitate formed. The precipitate was separated by filtration, washed with H2O, and dried under high vacuum for several hours to afford 2-amino-4-iodobenzamide as a tan solid (1.3 g, 52%). LC-MS (ESI) m/z 263 (M + H)+.

Statistics shows that 2-Amino-4-iodobenzoic acid is playing an increasingly important role. we look forward to future research findings about 20776-54-9.

Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; LIU, Gang; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ABRAHAM, Sunny; SETTI, Eduardo; WO2010/99379; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some scientific research about 20776-54-9

The synthetic route of 20776-54-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20776-54-9, name is 2-Amino-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., name: 2-Amino-4-iodobenzoic acid

Following the procedures described in Scheme 8, step 1 , compound 17 was prepared similarly. LC-MS: m/e = 303 [M+H]+.

The synthetic route of 20776-54-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANGEX PHARMACEUTICAL, INC.; WU, Wen-Lian; YANG, Zhiqiang; LEE, Francis; TAN, John Qiang; (76 pag.)WO2019/112719; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extracurricular laboratory: Synthetic route of 20776-54-9

The synthetic route of 2-Amino-4-iodobenzoic acid has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 20776-54-9, name is 2-Amino-4-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 20776-54-9

Embodiment 22 2-amino-4-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)benzoic acid 1-oxo-6-ethynyl-4,4-dimethylbenzothiopyran (263mg, 1.0mmol) and 2-amino-4-iodobenzoic acid (262mg, 1.2mmol) were added to a flask, followed by addition of Pd(PPh3)2Cl2 (42mg, 0.06mmol) and CuI (23mg, 0.0412mmol). After the flask was purged with argon for 3 times to remove oxygen, 4mL dry DMF and 0.2mL dry Et3N were added via syringe. Then the reaction was continued at 70C for 8 h and monitored by TLC. After completion of the reaction, the reaction solution was cooled to room temperature and the reaction was quenched with saturated ammonium chloride solution. The mixture was diluted with ethyl acetate, washed with saturated ammonium chloride solution and saturated sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash column chromatography (PE:EtOAc = 50:1) to give the product (275 mg, 78%). 1H NMR (500 MHz, pyridine) delta 8.37 (d, J = 8.1 Hz, 1H), 7.92 (d, J = 8.0 Hz, 1H), 7.86 (s, 1H), 7.59 (s, 1H), 7.36 (s, 1H), 7.03 (d, J = 8.1 Hz, 1H), 5.67 (s, 1H), 3.20 – 3.14 (m, 1H), 3.11 – 3.05 (m, 1H), 2.38 (ddd, J = 14.2, 10.3, 1.7 Hz, 1H), 1.74 – 1.68 (m, 1H), 1.26 (s, 3H), 1.17 (s, 3H); 13C NMR (126 MHz, pyridine) delta 171.06, 152.34, 145.52, 140.46, 132.80, 131.65, 130.43, 130.20, 127.92, 126.32, 119.79, 118.58, 112.43, 91.82, 90.33, 55.01, 43.59, 34.63, 30.93, 30.63, 29.80. ESI(+)-MS: 354.3 [M+1]+.

The synthetic route of 2-Amino-4-iodobenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences; Huazhong University of Science and Technology; CAO, Xin; YU, Biao; WANG, Ning; CHEN, Junwei; (88 pag.)EP3428155; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New learning discoveries about C7H6INO2

According to the analysis of related databases, 20776-54-9, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20776-54-9 as follows. Recommanded Product: 20776-54-9

Step A: To a solution of 2-amino-4-iodobenzoic acid (2.5 g, 9.50 mmol) in DMF (10 mL) at room temperature under argon were added EDCI (2.18 g, 11.40 mmol), 1-hydroxybenzotriazole (1.54 g, 11.40 mmol), DIEA (1.98 mL, 11.40 mmol), and ammonia (7.0 N solution in MeOH, 1.90 mL, 13.30 mmol). The dark solution was stirred at room temperature overnight and diluted with H2O until precipitate formed. The precipitate was separated by filtration, washed with H2O, and dried under high vacuum for several hours to afford 2-amino-4-iodobenzamide as a tan solid (1.3 g, 52%). LC-MS (ESI) m/z 263 (M+H)+.

According to the analysis of related databases, 20776-54-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMBIT BIOSCIENCES CORP.; US2012/53176; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple exploration of 2-Amino-4-iodobenzoic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 20776-54-9, name is 2-Amino-4-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20776-54-9, Computed Properties of C7H6INO2

Embodiment 19 2-amino-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoic acid 6-Ethynyl-4,4-dimethylbenzothiopyran (405.6mg, 2mmol) and 2-amino-4-iodobenzoic acid (263mg, 1mmol) were added to a flask, followed by addition of Pd(PPh3)2Cl2 (42mg, 0.06mmol) and CuI (23mg, 0.12mmol). After the flask was purged with argon for 3 times to remove oxygen, 10mL dry DMF and 0.2mL dry Et3N were added via syringe. Then the reaction was continued at 75C for 12 h and monitored by TLC. After completion of the reaction, the reaction solution was cooled to room temperature and the reaction was quenched with saturated ammonium chloride solution. The mixture was diluted with ethyl acetate, washed with saturated ammonium chloride solution and saturated sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash column chromatography (PE:EtOAc = 5:1) to give WYC-212 (286mg, 85%). 1H NMR (500 MHz, CDCl3) delta 7.88 (d, J = 8.3 Hz, 1H), 7.52 (d, J = 1.7 Hz, 1H), 7.18 (dd, J = 8.1, 1.8 Hz, 1H), 7.06 (d, J = 8.1 Hz, 1H), 6.84 (d, J = 1.3 Hz, 1H), 6.81 (dd, J = 8.3, 1.5 Hz, 1H), 3.08 – 3.02 (m, 3H), 1.99 – 1.94 (m, 2H), 1.35 (s, 6H); 13C NMR (126 MHz, CDCl3) delta 165.25, 165.23, 163.21, 161.20, 142.29, 134.42, 133.26, 133.25, 131.70, 131.64, 129.97, 129.27, 126.75, 125.15, 125.12, 117.73, 117.05, 116.92, 116.66, 116.47, 98.04, 98.02, 81.71, 61.62, 37.29, 33.13, 30.09, 23.38, 14.42. ESI(+)-MS: 338.3 [M+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Extended knowledge of 20776-54-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 20776-54-9, A common heterocyclic compound, 20776-54-9, name is 2-Amino-4-iodobenzoic acid, molecular formula is C7H6INO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) The S-acetyl-4-iodothiosalicylic acid, m.p. 184-186, was prepared from 4-iodoanthranilic acid according to the procedure described in Example 33 (a). Calcd for C9 H7 103 S: C, 33.55; H, 2.19; I, 39.40; S, 9.95%. Found: C, 33.70; H, 2.23; I, 39.20; S, 10.09%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Miles Laboratories, Inc.; US4221800; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extracurricular laboratory: Synthetic route of 20776-54-9

Statistics shows that 20776-54-9 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-iodobenzoic acid.

20776-54-9, name is 2-Amino-4-iodobenzoic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 20776-54-9

Embodiment 22 2-amino-4-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)benzoic acid 1-oxo-6-ethynyl-4,4-dimethylbenzothiopyran (263mg, 1.0mmol) and 2-amino-4-iodobenzoic acid (262mg, 1.2mmol) were added to a flask, followed by addition of Pd(PPh3)2Cl2 (42mg, 0.06mmol) and CuI (23mg, 0.0412mmol). After the flask was purged with argon for 3 times to remove oxygen, 4mL dry DMF and 0.2mL dry Et3N were added via syringe. Then the reaction was continued at 70C for 8 h and monitored by TLC. After completion of the reaction, the reaction solution was cooled to room temperature and the reaction was quenched with saturated ammonium chloride solution. The mixture was diluted with ethyl acetate, washed with saturated ammonium chloride solution and saturated sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash column chromatography (PE:EtOAc = 50:1) to give the product (275 mg, 78%). 1H NMR (500 MHz, pyridine) delta 8.37 (d, J = 8.1 Hz, 1H), 7.92 (d, J = 8.0 Hz, 1H), 7.86 (s, 1H), 7.59 (s, 1H), 7.36 (s, 1H), 7.03 (d, J = 8.1 Hz, 1H), 5.67 (s, 1H), 3.20 – 3.14 (m, 1H), 3.11 – 3.05 (m, 1H), 2.38 (ddd, J = 14.2, 10.3, 1.7 Hz, 1H), 1.74 – 1.68 (m, 1H), 1.26 (s, 3H), 1.17 (s, 3H); 13C NMR (126 MHz, pyridine) delta 171.06, 152.34, 145.52, 140.46, 132.80, 131.65, 130.43, 130.20, 127.92, 126.32, 119.79, 118.58, 112.43, 91.82, 90.33, 55.01, 43.59, 34.63, 30.93, 30.63, 29.80. ESI(+)-MS: 354.3 [M+1]+.

Statistics shows that 20776-54-9 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-iodobenzoic acid.

Reference:
Patent; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences; Huazhong University of Science and Technology; CAO, Xin; YU, Biao; WANG, Ning; CHEN, Junwei; (88 pag.)EP3428155; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com