Category: 2058236-52-3

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling, the main research direction is alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods.Related Products of 2058236-52-3.

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.

In some applications, this compound(2058236-52-3)Related Products of 2058236-52-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2058236-52-3, is researched, Molecular C19H16N2O, about Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides, the main research direction is acrylamide heterocyclization stereoselective catalyst palladium pyrox preparation pyrrolizidinone; crystal structure pyrrolizidinone preparation stereoselective heterocyclization acrylamide transition state; mol structure pyrrolizidinone preparation stereoselective heterocyclization acrylamide transition state.Application of 2058236-52-3.

The catalyst system of Pd(TFA)2/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. Pyrrolizidine derivatives were synthesized in good yield and excellent enantioselectivity. D-labeling experiments revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step account for the observed enantioselectivity.

In addition to the literature in the link below, there is a lot of literature about this compound((S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole)Application of 2058236-52-3, illustrating the importance and wide applicability of this compound(2058236-52-3).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Peng; Ji, Chong-Lei; Lu, Zhan published an article about the compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole( cas:2058236-52-3,SMILESS:C12=CC=NC(C3=N[C@H](CO3)CC4=CC=CC=C4)=C1C=CC=C2 ).Quality Control of (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2058236-52-3) through the article.

A nickel-catalyzed C-H heteroarylation at the 2-position of oxazolines e.g., (3aR,8aS)-3a,8a-Dihydro-8H-indeno[1,2-d]oxazole with heteroaryl halides such as 2-bromothiophene, 1-bromoisoquinoline, (E)-(2-bromovinyl)benzene, 2,6-dibromopyridine, etc. was developed. Various oxazoline-containing multidentate chiral ligands e.g., (3aR,8aS)-2-(thiophen-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole have been efficiently synthesized.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 2058236-52-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Nickel-Catalyzed C-H Heteroarylation of Chiral Oxazolines. Author is Lu, Peng; Ji, Chong-Lei; Lu, Zhan.

A nickel-catalyzed C-H heteroarylation at the 2-position of oxazolines e.g., (3aR,8aS)-3a,8a-Dihydro-8H-indeno[1,2-d]oxazole with heteroaryl halides such as 2-bromothiophene, 1-bromoisoquinoline, (E)-(2-bromovinyl)benzene, 2,6-dibromopyridine, etc. was developed. Various oxazoline-containing multidentate chiral ligands e.g., (3aR,8aS)-2-(thiophen-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole have been efficiently synthesized.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Nickel-Catalyzed C-H Heteroarylation of Chiral Oxazolines.SDS of cas: 2058236-52-3.

A nickel-catalyzed C-H heteroarylation at the 2-position of oxazolines e.g., (3aR,8aS)-3a,8a-Dihydro-8H-indeno[1,2-d]oxazole with heteroaryl halides such as 2-bromothiophene, 1-bromoisoquinoline, (E)-(2-bromovinyl)benzene, 2,6-dibromopyridine, etc. was developed. Various oxazoline-containing multidentate chiral ligands e.g., (3aR,8aS)-2-(thiophen-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole have been efficiently synthesized.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole( cas:2058236-52-3 ) is researched.Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole.Lu, Peng; Ji, Chong-Lei; Lu, Zhan published the article 《Nickel-Catalyzed C-H Heteroarylation of Chiral Oxazolines》 about this compound( cas:2058236-52-3 ) in Asian Journal of Organic Chemistry. Keywords: oxazoline chiral preparation; halide heteroaryl oxazoline heteroarylation nickel catalyst. Let’s learn more about this compound (cas:2058236-52-3).

A nickel-catalyzed C-H heteroarylation at the 2-position of oxazolines e.g., (3aR,8aS)-3a,8a-Dihydro-8H-indeno[1,2-d]oxazole with heteroaryl halides such as 2-bromothiophene, 1-bromoisoquinoline, (E)-(2-bromovinyl)benzene, 2,6-dibromopyridine, etc. was developed. Various oxazoline-containing multidentate chiral ligands e.g., (3aR,8aS)-2-(thiophen-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole have been efficiently synthesized.

I hope my short article helps more people learn about this compound((S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole)Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole. Apart from the compound(2058236-52-3), you can read my other articles to know other related compounds.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling, published in 2019, which mentions a compound: 2058236-52-3, mainly applied to alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods, Category: iodides-buliding-blocks.

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 2058236-52-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides. Author is Du, Wei; Gu, Qiangshuai; Li, Yang; Lin, Zhenyang; Yang, Dan.

The catalyst system of Pd(TFA)2/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. Pyrrolizidine derivatives were synthesized in good yield and excellent enantioselectivity. D-labeling experiments revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step account for the observed enantioselectivity.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole( cas:2058236-52-3 ) is researched.Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole.Yi, Hong; Mao, Wenbin; Oestreich, Martin published the article 《Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling》 about this compound( cas:2058236-52-3 ) in Angewandte Chemie, International Edition. Keywords: alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods. Let’s learn more about this compound (cas:2058236-52-3).

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.

If you want to learn more about this compound((S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole)Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(2058236-52-3).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application In Synthesis of (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling. Author is Yi, Hong; Mao, Wenbin; Oestreich, Martin.

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com