Category: 20555-91-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,2-Dichloro-4-iodobenzene

A 3M solution of n-BuLi in hexane (24 mL) was added to anhydrous THF (60 mL) at -78 C., followed by the addition of a solution of compound X-A-49 (15 g) in anhydrous THF (10 mL) dropwise. The mixture was stirred for an hour, then compound X-B-49 was added dropwise. The resulting mixture was stirred at -78 C. for an additional hour then allowed to warm up gradually to room temperature. After stirring at room temperature for 3 hours, the reaction was quenched by adding a saturated aqueous NH4Cl solution dropwise. The separated organic layer was set aside. The aqueous was concentrated to remove most of the THF, then extracted with EtOAc (3×30 mL). The combined organic solution was dried over Na2SO4 and concentrated. The residue was purified by column chromatography eluting with petroleum ether/EtOAc (5:1) to give 9.5 g of compound X-C-49 in 54% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20555-91-3.

Reference:
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 20555-91-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20555-91-3 name is 1,2-Dichloro-4-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example HI; Preparation of l -(3,4-dichlorophenyl)-bicvclo[3 1 0]hexan-2-amines and 1-C3.4- dichlorophenyl)-bicvclo[3 1 0]hexan-3 -amines using Reaction Schemes 1 and 2A. Synthesis of 3-(3,4-diehlorophenyl)prop-2-vn-l-ol EPO Bis(t?phenylphosphine)palladium(II) chlonde (120 mg, 0 171 mmol) was added to a stirred solution of propargyl alcohol (5 24 g, 93 4 mmol, 1 02 eq), 1 -iodo- 3,4-dichlorobenzene (25 0 g, 91 6 mmol, 1 eq), t?ethylamine (18 5 g, 183 2 mmol, 2 eq), and copper iodide (60 mg, 0 32 mmol) in THF (50 mL) The mixture was stirred at 350C for 12 h under a nitrogen atmosphere The mixture was then filtered through a bed of celite and the filtrate was washed with ethyl acetate The filtrate was then concentrated at 350C (vac = 28 in Hg) using a rotary evaporator The residue was pu?fied using a silica gel column (4 1 heptane/ethyl acetate – ? 2 1 heptane/ethyl acetate) to give the desired product as a light yellow solid ( 17 10 g, 85 2 mmol, 93%) 1H NMR (400 MHz, CHLOROFORM-^) delta ppm 4 53 (s, 2H) 7 19 (d, I H) 7 29 (d, IH) 7 49 (s, IH)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dichloro-4-iodobenzene, and friends who are interested can also refer to it.

Reference:
Patent; DOV PHARMACEUTICAL, INC.; WO2008/57575; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H3Cl2I

To a solution of l,2-dichloro-4-iodobenzene (Intermediate la) (5.6g, 20.75mmol), tert-butyl 4-(but-3-yn-2-ylcarbamoyl) piperazine-l-carboxylate (Intermediate 8) (7g, 24.9lmmol) and triethyl amine(8.66mL, 62.25mmol) in DMF(lOOmL) was purged with argon gas for 20 min. Then Copper Iodide (0.79g, 4.l5mmol) and Tetrakis(triphenylphosphine) palladium(O) (2.39g, 2.07 mmol) were added at RT and the reaction mixture was again purged for 10 min. The reaction mixture was stirred for 2h at 80C. After completion of reaction, it was poured into ice water and extracted with EtOAc. The EtOAc layer was dried; concentrated and purified by combiFlash silica gel column (hexanes/EtOAc=40/60) to obtain the title compound (7.0g, 79.8%). LCMS: m/z =426.1 [M]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20555-91-3.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; CHIKKANNA, Dinesh; KHAIRNAR, Vinayak V.; RAMACHANDRA, Muralidhara; SATYAM, Leena Khare; (139 pag.)WO2019/142126; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1,2-Dichloro-4-iodobenzene

[0268] To a solution of 1,2-dichloro-4-iodobenzene (1.0 g, 3.68 mmol) in ether (10 mL) at 0 C. was added iPrMgCl (2.2 mL, 2M in Et2O) dropwise and the resulting solution stirred at 0 C. for 30 minutes and room temperature 1 hour. The reaction mixture was recooled to 0 C. and cyclopropylacetonitrile (0.34 mL, 1.0 eq.) was added. The reaction mixture was stirred at 0 C., room temperature 1 hour, then quenched by the addition of 1N HCl. The resulting solution was stirred at room temperature 2 hours and extracted with CH2Cl2. The combined organics were dried over Na2SO4, filtered, and concentrated. The crude product was purified by flash chromatography using a 100% hexanes to 10% EtOAc in hexanes solution gradient as eluent (0.10 g, 21% yield). LCMS: MH+=227.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20555-91-3.

Reference:
Patent; Schering Corporation; US2003/232837; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The air was exchanged 3 times with nitrogen in a 25 mL test tube reactor. The first step was to first substrate 1a (0.2 mmol, 57.1 mg), pinacol borate (0.4 mmol, 102 mg), Pd (PPh3) 4 (0.02 mmol, 23.1 mg), cesium carbonate (0.4 mmol, 130 mg) Weighed into the reaction tube, vacuumed for nitrogen, and added tetrahydrofuran (2 mL) and water (0.014 mL) under nitrogen, and the reaction was heated to 60 C for 12 hours; the second step was added for 2 hours ( 0.24 mmol,65.5 mg) continued to react at this temperature for 12 hours. After TLC detects the reaction,The system was cooled to room temperature. Directly add silica gel, spin dry column chromatography,Obtained a reddish brown solid 3ah (41%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dichloro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong University of Technology; Liu Hui; Cui Jie; Meng Long; Chi Xiaochen; Sun Xi; Cao Chengqiang; Liu Qing; Li Xinjin; Zhou Zhen; Dong Yunhui; (16 pag.)CN109553555; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1,2-Dichloro-4-iodobenzene

a) (3,4-Dichloro-phenyl)-propynoic acid ethyl ester (Vb) Under argon atmosphere, a four neck flask was charged with 1,2-dichloro-4-iodo-benzene (222.8 g, 0.80 mol), bis(triphenylphosphine) palladium(II) chloride (11.2 g, 16.0 mmol, 2 mol %), copper(I) iodide (6.09 g, 32.0 mmol, 4 mol %) and dry THF (2.4 l). At r.t., cesium carbonate (526.6 g, 1.60 mol, 2 eq.) was added over 5 minutes. Afterward, propynoic acid ethyl ester (168.6 ml, 1.60 mol, 2 eq.) was added, and the reaction mixture was stirred overnight at 35 C. An additional portion of propynoic acid ethyl ester (17.0 ml, 0.16 mol, 0.2 eq.) was added, and the reaction was stirred for another 4 h at 35 C. The reaction mixture was evaporated to dryness, and the residue was taken up in toluene (0.8 l) and heptane (1.6 l). The resulting suspension was stirred at 40 C. for 1 h and filtered over celite. The filtrate was concentrated, and the product was purified by silica gel filtration (toluene/heptane 1:2) to yield 175.0 g (89%) of Vb as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hoffmann-Emery, Fabienne; Puentener, Kurt; Ratni, Hasane; US2010/152462; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: An appropriate phenylacetamide (0.12 mmol, 1 equiv), an appropriate iodo compound (0.48 mmol, 4 equiv), Pd(OAc)2 (2.7 mg, 10 mol%), and AgOAc (50 mg, 0.3 mmol, 2.5 equiv) in anhydrous toluene (3 mL) was heated at 110 C for 24 h under a nitrogen atmosphere. After the reaction period, the solvent was evaporated in vacuo to afford a crude reaction mixture. Purification of the crude reaction mixture by column chromatography furnished the corresponding arylated products 4a-q/7a-f (bis arylation products), 3o,r/6a,b/8e,f/9a,b (mono arylation products) (see corresponding Tables/Schemes for specific examples and reaction conditions).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dichloro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Bisht, Narendra; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 72; 39; (2016); p. 5886 – 5897;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of 8-aminoquinoline (0.4mmol), an appropriate carbonyl chloride (0.4mmol), an appropriate aryl iodide (0.16-0.24mmol, 4-6 equiv), Pd(OAc)2 (10mol %) and Ag2CO3 (0.6-0.8mmol, 1.5-2 equiv) was heated in o-xylene (2mL) at 110 C for an appropriate reaction period (12-36 h). Then, reaction mixture was cooled to rt and the solvent evaporated in vacuo to give the crude product, which was purified by chromatography to give the corresponding C-H arylated products (see the respective Tables 1-4/Scheme 2 for the specific entries and reaction conditions).

The synthetic route of 1,2-Dichloro-4-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mohan, Sruthi; Gopalakrishnan, Bojan; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 72; 39; (2016); p. 5853 – 5863;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

General procedure: To a screw-capped vial (50 ml) were added aryl iodides 1(1.0 mmol), benzonitrile 2a (155 mg, 1.5 mmol), K2CO3 (276 mg,2.0 mmol), NaOH (40 mg,1.0 mmol), CuI (19 mg, 0.1 mmol), DMEDA(9 mg, 0.1 mmol), and [bmim]PF6 (14 mg, 0.05 mmol) in water(2 ml). The vial was flushed with nitrogen then sealed with the cap,and allowed to stir at 100 C for the specific reaction time. Thereaction mixture was extracted with EtOAc (315 ml). The combined organic extracts were dried over Na2SO4 for 12 h andevaporated under vacuum. The crude products were purified ina silica gel column for further purification, using PE/EtOAc (5:1) asthe eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang; Tetrahedron; vol. 69; 48; (2013); p. 10463 – 10469;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 20555-91-3,Some common heterocyclic compound, 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, molecular formula is C6H3Cl2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 10 mL glass screw cap tube capped with a rubber septum, palladium acetate Pd(OAc)2, (5 mg, 0.023 mmol), 1,3-bis(diphenylphosphino)propane dppp, (9 mg, 0.023 mmol) were introduced under argon atmosphere. Then, 3 mL of freshly distilled toluene) were added under argon. The mixture was stirred for 10 min to allow formation of the catalyst. Then securinine 1 (100 mg, 0.46 mmol), potassium carbonate (K2CO3, 127 mg, 0.92 mmol) and the desired iodoarene (0.92 mmol) were added. The septum was replaced by a screw cap, and the mixture was stirred at 130 C, in an oil bath. After 24 h stirring, the reaction mixture was brought to room temperature and diluted with ethyl acetate (5 mL). The reaction mixture was filtered through a pad of Celite eluting with AcOEt (20 mL). The organic layer was extracted with a saturated aqueous solution of sodium hydrogen carbonate (10 mL) and brine (10 mL). The organic layer was then dried over anhydrous magnesium sulfate, filtered and concentrated to dryness. Purification by flash column chromatography on silica gel (pentane-ethyl acetate) affords the desired coupling product. 4.1.2.1.12 (6S,11aR,11bS)-5-(3,4-Dichlorophenyl)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one (2l) Yield: 70%. Orange solid; m.p. 65-68 C; Rf 0.37 (petroleum ether-AcOEt, 70:30); [alpha]D20 – 477 (c = 0.11, CHCl3); 1H NMR (300 MHz, CDCl3): delta = 7.58 (d, J = 2.2 Hz, 1H), 7.46 (d, J = 8.4 Hz, 1H), 7.34 (dd, J = 8.4, 2.2 Hz, 1H), 6.81 (d, J = 1.3 Hz, 1H), 5.62 (s, 1H), 4.27 (d, J = 4.3 Hz, 1H), 2.90-2.84 (m, 1H), 2.63 (dd, J = 9.4, 4.3 Hz, 1H), 2.32-2.23 (m, 1H), 2.18 (dd, J = 11.2, 2.5 Hz, 1H), 1.89-1.82 (m, 2H), 1.68-1.47 (m, 4H), 1.27-1.12 (m, 1H); 13C NMR (75 MHz, CDCl3): delta = 173.5, 169.5, 147.6, 138.3, 133.5, 133.2, 130.8, 128.1, 125.4, 116.5, 105.6, 88.9, 62.9, 61.5, 48.7, 41.7, 27.3, 25.7, 24.0. MS (CI, NH3): m/z = 362 [M+ + H]; HRMS calcd for C19H17Cl2NO2H [M+ + H]: 362.07091; found: 362.07151, error = 1.7 ppm.

The synthetic route of 20555-91-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Perez, Marc; Ayad, Tahar; Maillos, Philippe; Poughon, Valerie; Fahy, Jacques; Ratovelomanana-Vidal, Virginie; European Journal of Medicinal Chemistry; vol. 109; (2016); p. 287 – 293;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com