Category: 2043-57-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, A new synthetic method of this compound is introduced below., Safety of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

2.4. Synthesis of 1-chloro-3-1H,1H,2H,2H-perurooctyl-5,5-dimetylhydantoin (Cl-FODMH)3-1H,1H,2H,2H-perurooctyl-5,5-dimetylhydantoin (FODMH)was synthesized using similar procedures as in the preparation ofODMH. Briey, 3.20 g DMH were dissolved in 30 mL methanol inthe presence of 1.68 g potassium hydroxide. The mixture was keptat 50 C for 30 min. After evaporation of the solvent, the potassiumsalt of DMH was dried in a vacuum oven at 60 C for three days. Theanhydrous salt was then dispersed in 100 mL N,N-dime-thylformamide (DMF) at 95 C for 10 min under constant stirring,after which 11.85 g IFO were added into the mixtures. The reactionwas continued for 4 h at 95 C. At the end of the reaction, theformed KI was ltered off. After the removal of DMF by distillationunder reduced pressure, the residual substance was recrystallizedfrom ethanol. 3-1H,1H,2H,2H-perurooctyl-5,5-dimetylhydantoin(FODMH) was obtained as white powders with a yield of 60.7%(7.22 g).In the preparation of Cl-FODMH, 0.5 g FODMH and 0.74 g tri-chloroisocyanuric acid (TCCA) were dissolved in acetone [10]. Here,TCCA was employed because our screening tests showed that usingchlorine bleach as the chlorination agent could not chlorinateFODMH successfully due to the very hydrophobic nature ofFODMH. The solution was vigorously stirred for 30 min at ambienttemperature. At the end of the reaction, acetone was evaporated,hexane was added to the mixtures, and the insoluble solids wereltered off. After removing hexane from the ltrate by evaporation,Cl-FODMH was obtained as white powders with a yield of 59.2%.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lin, Jiajin; Jiang, Fuguang; Wen, Jianchuan; Lv, Wei; Porteous, Nuala; Deng, Ying; Sun, Yuyu; Polymer; vol. 68; (2015); p. 92 – 100;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 2043-57-4, These common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The entire procedure including the isolation and characterization of the product was performed under an inert atmosphere (N2). n-BuLi (0.94 mL, 2.4 mmol, 1.0 equiv, 2.5 mol/L solution in hexane) was added at r.t. to a solution of Ph2PH (438 mg, 2.40 mmol, 1.0 equiv) in abs THF (2 mL). After stirring the mixture for 5 min at 23 C, perfluorinated iodide 19 (1.12 g, 2.40 mmol, 1.0 equiv) was added and the mixture was further stirred for 17 h at 23 C. The mixture was then filtered using a reversible frit and the resulting solution was evaporated to furnish the product 20 (1.11 g, 2.09 mmol, 89%) as an off-white solid; mp 40 C. IR (ATR): 3072 (w), 1482 (w), 1439 (w), 1364 (w), 1235 (m), 1182 (s), 1139 (s), 1121 (m), 1070 (m), 1028 (w), 925 (w), 847 (w), 746 (m), 735 (m), 723 (m), 693 cm-1 (s). 1H NMR (300 MHz, CDCl3): delta = 2.05-2.23 (m, 2 H), 2.24-2.37 (m, 2 H), 7.33-7.41 (m, 6 H), 7.42-7.51 (m, 4 H). 31P{1H} NMR (203 MHz, CDCl3): delta = -16.05 (s). The 13C NMR spectrum was in accordance with literature data. HRMS (ESI): m/z [M + Na]+ calcd for C20H14F13NaP: 555.0523; found: 555.0529.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Alpers, Torben; Muesmann, Thomas W. T.; Temme, Oliver; Christoffers, Jens; Synthesis; vol. 50; 17; (2018); p. 3531 – 3539;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, A new synthetic method of this compound is introduced below., Recommanded Product: 2043-57-4

1/T,liy,2No.,2No.-Perfluorooctyl thiouronium iodide (5); In a 100 mL round bottomed flask, thiourea (1.13g, 14.8 mmol) was added to a stirred solution of lH,lH,2H,2H-perfluorooctyl iodide (3.62 mL, 14.8 mmol) in ethyl alcohol (14.0 mL). The mixture was left to reflux at 78C for 13 hours under a nitrogen atmosphere then cooled to room temperature. The solvent was removed under reduced pressure to reveal a cream/white solid (8.10 g, 14.7 mmol, quantitative yield). This was used in the next step without further purification.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISIS INNOVATION LIMITED; GOUVERNEUR, Veronique; BEJOT, Romain; WO2010/7363; (2010); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2043-57-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2043-57-4 as follows.

General procedure: 2-(Perfluorodecyl)ethyl iodide (5.26 g, 7.81 mmol), 4-mercaptophenol (0.94 g, 7.44 mmol), andK2CO3 (2.06 g, 14.88 mmol) was added in acetone (80 mL) in a 200 mL recovery flask, and theresulting mixture was heated at reflux for 3 days. The reaction mixture was allowed to cool toroom temperature. After 1 N HCl aqueous solution was added to the mixture until pH ? 3,saturated NaCl aqueous solution (100 mL) was added to it and the resulting solution wasextracted with EtOAc (100 mL × 3). The organic layers were combined and dried with MgSO4,and after filtration, the filtrate was concentrated using a rotary evaporator under reduced pressure.The crude product was purified by silica gel column chromatography (eluent: CHCl3) to give A-10 (3.00 g, 4.46 mmol) in 60% yield as colorless powder.

According to the analysis of related databases, 2043-57-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yoshida, Tomohiro; Hirakawa, Tomomi; Nakamura, Toru; Yamada, Yasuhiro; Tatsuno, Hiroko; Hirai, Masayuki; Morita, Yuki; Okamoto, Hiroaki; Bulletin of the Chemical Society of Japan; vol. 88; 10; (2015); p. 1447 – 1452;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2043-57-4,Some common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-iodooctane (30.8 g, 65 mmol) was dissolved in a mixture of pentane (180 mL) and diethyl ether (120 mL) The solution was stirred and cooled to -78 C before addition of 1.6 M t-butyllithium in hexane (45 mL, 72 mmol). After stirring for 15 min at this temperature freshly distilled trichloromethylsilane (2.75 g, 18.4 mmol) was added. The mixture was stirred for further 2 h at -78 C and then 1 h at 0 C, thereafter it was poured onto ice with stirring for 15 min. The resulting biphasic mixture was filtered through silica gel. The layers were separated and the aqueous phase was extracted with diethyl ether (3* 50 mL). The combined organic phases were dried (MgSO4) and solvents evaporated in vacuum to afford a yellow oil (17.2 g, 16 mmol, 85%). 1H NMR delta = 0.18 (s, 3H, SiCH3), 0.91 (m, 6H, SiCH2CH2CF2), 2.07 (m, 6H, CH2CF2). 13C {1H} NMR delta = -6.59 (s, SiCH3), 2.59 (s, SiCH2), 25.54 (t, 2JCF = 24.0 Hz, CH2CF2), 106.80-125.18 (m, CF3, CF2). 19F NMR delta = -127.13 (m, 6F, CF2), -124.17 (m, 6F, CF2), -123.77 (m, 6F, CF2), -122.78 (m, 6F, CF2), -117.07 (m, 6F, CF2), -81.99 (t, 9F, 3JHH = 10.1 Hz, CF3). 29Si {1H} NMR delta = 7.06.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, its application will become more common.

Reference:
Article; Stra?ak, Toma?; ?t’astna, Lucie ?ervenkova; Bilkova, Veronika; Skoupa, Veronika; Karban, Jind?ich; Cu?inova, Petra; ?ermak, Jan; Journal of Fluorine Chemistry; vol. 178; (2015); p. 23 – 29;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 2043-57-4

15 mL of freshly distilled and dry THF under nitrogen was cooled to -78 C. 4.0 mL of LDA in THF (1 .0 M) (4 mmol) was added quickly. 0.332 mg [1 .8 mmol] of 4,4′-dimethyl-2,2′-bipyridine, dissolved in 3 ml of dry THF, were added and kept under stirring for 30 minutes at – 78 C, then for 15 minutes at -10 C and finally the temperature was cooled again at -78 C for further 15 minutes. Then 1 .896 g [4 mmol] of 1 H,1 H,2H,2H-perfluorooctyl iodide were added. After the addition, the reaction mixture was allowed to warm slowly to room temperature. The reaction was added with 20 ml of brine and extracted with diethyl ether and dried over Na2SO4. Evaporation u.v. (30 C/2.4 kPa) gave a crude product, that was purified by silica gel column chromatography eluting with methanol/dichloromethane solvent mixture, using an appropriate gradient (2:98 final eluting solvent mixture ratio). After removal of the solvent u.v. (30 C/ 2.4 kPa) 0.512 g of the desired compound was obtained as a white solid. 1H-NMR (400 MHz, CDCI3): 8.60 (d, 2H, J=5.1 Hz), 8.28 (s, 2H), 7.16 (dd, 2H, J=1 .6 Hz, J=3.3 Hz), 2.82 (t, 4H, J=7.5 Hz), 2.21 -1 .99 (m, 8H) ppm. 19F-NMR (376.3 MHz, CDCI3): -126.1 , -123.4, -122.8, -121 .9, -1 14.1 , -80.81 ppm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2043-57-4.

Reference:
Patent; TOZZI GREEN S.P.A.; BORZATTA, Valerio; ZAMA, Isabella; RIGHI, Paolo; GORNI, Giacomo; (39 pag.)WO2019/29789; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 2043-57-4,Some common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) In another 20 liters of pressure-resistant reactor, 2000 g of perfluorohexylethyl iodide obtained in (1) was added, and the mixture was heated to 125 C with stirring. 6000 g of 4% aqueous dimethylformamide was added to the reactor at a rate of 80 g/min by a metering pump, and the temperature was controlled at 125 to 130 C, the pressure was not higher than 0.35 MPa, and the reaction was continued for 32 hours, and the heating was removed. Neutralize with 2222 g of 11.3% potassium hydroxide aqueous solution, separate the organic phase, and then wash once with 2222 g of deionized water, separate the organic phase, and remove the light component to obtain 1420 g of fluoroalcohol 88% and fluorinated olefin 5.5%. Intermediate product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, its application will become more common.

Reference:
Patent; Jinan Qifu New Materials Co., Ltd.; Shandong Chemical Institute; Li Haijing; Zhang Liting; (6 pag.)CN108911983; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H4F13I

General procedure: Perfluoroalkylethyl iodide (1.0 mol equiv.) (3-4 mmol) and NaN3 (1.2 mol equiv.) were added to dry DMSO (2 mL) in a 10 mL CEM microwave glass reactor tube, a magnetic stirring bead added and the system sealed. The tube was subjected to stirring and microwave irradiation at 250 W and 65 C for 1 h then immediately cooled to r.t.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2043-57-4, its application will become more common.

Reference:
Article; Francis, Dominic V.; Miles, D. Howard; Mohammed, Adnan I.; Read, Roger W.; Wang, Xiaobei; Journal of Fluorine Chemistry; vol. 132; 11; (2011); p. 898 – 906;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2043-57-4, A common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 50 mL three-necked round bottom flask equipped with a stirrer and a dropping funnel was charged with 0.01 mol (0.97 g) of diallyl Amine and 20 mL of anhydrous ether were added to the raw material in an amount of 10% tetrabutylammonium bromide as the catalyst. The reaction was cooled with an ice-water bath. 0.011 mol (5.22 g) of perfluorohexyl ethyl iodide was slowly added dropwise to the reaction system through a dropping funnel in. After dripping, it rises to room temperature. The reaction was stirred for another 6 h. GC tracking reaction end point. After completion of the reaction, the reaction mixture was oxidized with 2% Sodium washing. The organic layer was separated, washed with water, then dried over anhydrous magnesium sulfate, and the solvent was removed by vacuum distillation and excess Fluorohexyl ethyl iodide. 4.16 g of a pale yellow liquid product was obtained in a yield of 93.9%.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Liwen Technology Co., Ltd.; Jiangsu Liwen Chemical Co., Ltd.; Jiangxi Liwen Chemical Co., Ltd.; Liang Haibo; Chen Yixin; Xie Wenjian; Wang Jiangbing; Xin Weixian; Chen Xinzi; (21 pag.)CN106866470; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2043-57-4, category: iodides-buliding-blocks

The alcohol of formula (2-2) was synthesized by referring to JP-A-2010-280799. Concretely, 2- (perfluorohexyl) ethyl iodide (manufactured by Daikin Industries, Ltd., 5.4 g, 11.4 mmol), 4-hydroxythiophenol (1.3 g, 10.3 mmol), potassium carbonate (1.7 g, 12.0 mmol) was dissolved in acetone (50 mL) and heated under reflux for 24 hours. After filtration of the reaction mixture, the solvent was distilled off under reduced pressure by an evaporator. Ethanol was added to the residue and dissolved by heating, water was added, and the solution was cooled with ice water to precipitate crystals. The precipitated crystals were collected by suction filtration to obtain an alcohol (4.2 g, 86%) of the formula (2-2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yamaguchi University; kamoto, Hiroaki; Morita, Yuki; (21 pag.)JP2016/175864; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com