Category: 202982-67-0

Adding a certain compound to certain chemical reactions, such as: 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202982-67-0, COA of Formula: C6H3ClFI

To a mixture of 4-chloro-3-fluoroiodobenzene (74.27 g, 284 mmol) and cesium carbonate (185.0 g, 568 mmol) in tetrahydrofuran (730 mL) was added under an argon atmosphere cuprous iodide (2.16 g, 11.4 mmol) and bis(triphenylphosphine)palladium (II) chloride (3.98 g, 5.7 mmol). Ethyl propiolate (57.0 g, 575 mmol) was added dropwise over a period of 20 min. The resulting dark brown suspension was stirred for 38 h at 35 C., then filtrated over Hyflo and the residue was washed with tetrahydrofuran (285 ml). The filtrate was evaporated and purification of the residue by chromatography (SiO2, heptane: ethyl acetate=90:10) afforded the title compound (57.1 g, 89%) as a yellow liquid. MS m/e: 226.0 [M]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-fluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Knust, Henner; Koblet, Andreas; Nettekoven, Matthias; Ratni, Hasane; Riemer, Claus; Vifian, Walter; US2011/152233; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 202982-67-0

A few drops of l -chloro-2-fluoro-4-iodobenzene (31.1 g, 121 mmol) in 50 mL of diethyl ether was added to the mixture of magnesium turnings (3.29 g, 136 mmol) and diethyl ether (50 mL) under nitrogen. After the reaction was initiated, the rest of the l-chloro-2-fluoro-4-iodobenzene ether solution was added at room temperature, and the reaction mixture was stirred at the same temperature for 1 h. This grignard reagent solution was added slowly to a solution of tert-butyl 4-(l-cyano-2- methoxy-2-oxoethy lidene)piperi dine- 1-carboxy late (10 g, 35.7 mmol) and copper(I) iodide (1.631 g, 8.56 mmol) in THF (200 mL) at 0 C, and the reaction mixture was stirred at 0 C for 1 h. Saturated ammonium chloride solution (100ml) was added, and the mixture was diluted with 500ml of ethyl acetate. The organic layer was washed with the water and brine solution, dried with the sodium sulphate and concentrated. The crude product was purified via silica gel chromatography eluteing with 20% of ethyl acetate in pet ether to give tert-butyl 4-(4-chloro-3-fluorophenyl)-4-(l-cyano-2-methoxy-2- oxoethyl)piperi dine- 1-carboxy late (12 g, 77%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WU, Yong-Jin; GUERNON, Jason M.; (102 pag.)WO2018/81384; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 202982-67-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Reference Production Example 4To a solution of 3.0 g of 2-fluoro-4-iodochlorobenzene and 3.6 g of methyl (3, 3, 3-trifluoropropylsulfonyl) acetate in 100 ml of 1,4-dioxane were added 1.40 g of sodium hydride (60% dispersion in paraffin liquid), 242 mg of (dibenzylideneacetone) (chloroform) dipalladium (0) and 368 mg of triphenylphosphine at room temperature, and the mixture was stirred at 800C for 5 days. To the reaction mixture was added 10% hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.8 g of methyl (4-chloro-3- fluorophenyl) -(3,3, 3-trifluoropropylsulfonyl) acetate represented by the following formula:1H-NMR (CDCl3, TMS): delta (ppm) 7.43-7.53 (2H, m) , 7.31 (IH, dd) , 5.02 (IH, s), 3.90 (3H, s) , 3.17-3.58 (2H, m) , 2.44- 2.77 (2H, m) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-fluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/14268; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 202982-67-0,Some common heterocyclic compound, 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of Example 47C (62 mg, 0.151 mmol), l-chloro-2-fluoro-4-iodobenzene (40.7 mg, 0.159 mmol) and cesium carbonate (148 mg, 0.454 mmol) in dioxane (2.0 mL) was bubbled with argon for 5 minutes and treated with dicyclohexyl(2′,4′,6′-triisopropyl-[l,l’-biphenyl]-2- yl)phosphine (10.82 mg, 0.023 mmol) and Pd2(dba)3 (tris(dibenzylideneacetone)dipalladium(O)) (11.08 mg, 0.012 mmol). The reaction mixture was flushed with argon for an additional five minutes and stirred at 95 C for 1 hour. After cooling, the reaction mixture was treated with sodium tetrahydroborate (11.45 mg, 0.303 mmol) and stirred for 2 hours. Volatiles were removed, and the residue was purified by HPLC (20-100% acetonitrile in 0.1% trifluoroacetic acid/water on Phenonemex CI 8 10 muiotaeta column) twice to provide the title compound (33mg, 40%). H NMR (400 MHz, DMSO-d6) delta ppm 7.71 (dd, J = 12.8, 2.5 Hz, 1H), 7.48 (td, J = 8.8, 4.8 Hz, 2H), 7.29 (s, 1H), 7.33 – 7.12 (m, 1H), 7.06 (dd, J = 11.4, 2.9 Hz, 1H), 6.84 (ddd, J = 9.0, 2.9, 1.2 Hz, 1H), 5.13 (s, 1H), 4.48 (s, 2H), 4.13 – 4.05 (m, 1H), 3.67 (dd, J = 9.2, 6.5 Hz, 2H), 3.45 (dd, J = 9.1, 6.6 Hz, 2H), 2.39 (ddd, J = 12.5, 9.4, 2.5 Hz, 1H), 2.16 – 2.00 (m, 2H), 2.03 – 1.73 (m, 7H); MS (ESI+) m/z 540.2 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-3-fluoroiodobenzene, its application will become more common.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; TONG, Yunsong; XU, Xiangdong; SHI, Lei; CHUNG, Seungwon; XIONG, Zhaoming; MURAUSKI, Kathleen; ZHANG, Qingwei, I.; BROWN, Brian, S.; DART, Michael, J.; (267 pag.)WO2019/90081; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 202982-67-0 as follows. name: 4-Chloro-3-fluoroiodobenzene

Tris(dibenzylideneacetone)dipalladium(0) (47.6 mg, 0.05 mmol), 2- (dicyclohexylphosphino)-2′,4′,6′-triisopropylbiphenyl (XPhos, 49.6 mg, 0.10 mmol), 4-chloro-3- fluoroiodobenzene (400 mg, 1.56 mmol, Aldrich), teri-butyl 2,6-diazaspiro[3.3]heptane-2- carboxylate, oxalic acid (300 mg, 1.04 mmol, ArkPharm), and cesium carbonate (1017 mg, 3.12 mmol) were suspended in dioxane (12 mL). The reaction mixture was stirred at 98 C for 18 hours and then cooled to ambient temperature. The crude reaction mixture was combined with 5 grams of Celite and concentrated under reduced pressure to a free flowing powder. The powder was directly purified by reversed-phase flash chromatography [Interchim PuriFlash C18XS 30 mupiiota 175 g column, flow rate 100 mL/minute, 5-100% gradient of acetonitrile in buffer (0.025 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide)] to give the title compound (0.27 g, 0.83 mmol, 79 % yield).JH NMR (400 MHz, DMSO-de) delta ppm 7.29 (t, J = 8.6 Hz, 1H), 6.42 (dd, J = 11.7, 2.6 Hz, 1H), 6.25 (ddd, J = 8.8, 2.6, 0.8 Hz, 1H), 4.01 (s, 4H), 3.94 (s, 4H), 1.38 (s, 9H); MS (ESI+) m/z 327 (M+H)+.

According to the analysis of related databases, 202982-67-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen Ann; SIDRAUSKI, Carmela; FROST, Jennifer M.; TONG, Yunsong; XU, Xiangdong; SHI, Lei; XIONG, Zhaoming; (165 pag.)WO2019/90090; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 202982-67-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: All reactions were carried out in an 80 mL Teflon-lined stainless steel reactor equipped with a magnetic stirring bar. Typically, in a glovebox, the aryl iodides (1.0 mmol), RhI3(0.025 mmol), PPh3 (0.1 mmol), Et3N (1.2 mmol), and DMA (2 mL) were loaded into the reactor. Then, the autoclave was screwed up, charged with CO and H2 to a total pressure of 10 bar (1:1) and transferred to an oil bath preheated at 90 C, which was controlled by a Haake-D3 temperature controller. After completion of the reaction, the reactor was cooled in iced water and the gas carefully vented. The conversion and yield of the aryl iodides and arylaldehydes were determined by GC analysis using dodecane as an internal standard. For yield determination of the other products, the reaction mixture was first analyzed by GC-MS to determine the structures of the aromatic aldehyde products. Then, CH2Cl2 (5 mL) was added to the reaction mixture, after which deionized water (10 mL) was added to extract the solvent DMA for 5 times. The organic layer was dried over anhydrous Na2SO4, concentrated by rotary evaporation and finally purified by column chromatography on silica gel using n-hexane/ethyl acetate as eluent to obtain the pure products and isolated yields.

The synthetic route of 4-Chloro-3-fluoroiodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Suqing; Liu, Zhenghui; Mu, Tiancheng; Wang, Peng; Yan, Zhenzhong; Yu, Dongkun; Zhao, Xinhui; Beilstein Journal of Organic Chemistry; vol. 16; (2020); p. 645 – 656;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 202982-67-0, The chemical industry reduces the impact on the environment during synthesis 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, I believe this compound will play a more active role in future production and life.

To a mixture of 4-chloro-3-fluoroiodobenzene (74.27 g, 284 mmol) and cesium carbonate (185.0 g, 568 mmol) in tetrahydrofuran (730 mL) was added under an argon atmosphere cuprous iodide (2.16 g, 11.4 mmol) and bis(triphenylphosphine)palladium (II) chloride (3.98 g, 5.7 mmol). Ethyl propiolate (57.0 g, 575 mmol) was added dropwise over a period of 20 min. The resulting dark brown suspension was stirred for 38 h at 35 C, then filtrated over Hyflo and the residue was washed with tetrahydrofuran (285 ml). The filtrate was evaporated and purification of the residue by chromatography (Si02, heptane: ethyl acetate = 90: 10) afforded the title compound (57. lg, 89 %) as a yellow liquid. MS m/e: 226.0 [M]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-fluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; KNUST, Henner; KOBLET, Andreas; NETTEKOVEN, Matthias; RATNI, Hasane; RIEMER, Claus; VIFIAN, Walter; WO2011/73160; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 202982-67-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a Schlenk tube, a solution of 4-Chloro-3-fluoroiodobenzene (7.3 g, 28.4 mmol), K3PO4 (16.1 g, 75.9 mmol), (S)-methylpyrrolidine-3-carboxylate (1271) hydrochloride (3.1 g, 19.0 mmol) and P(tBu)3 HBF4 (551 mg, 1.90 mmol) in dioxane (150 mL) was purged with N2 (3x). Pd(OAc)2 (213 mg; 0.95 mmol) was added and the reaction mixture was stirred at 100C for 16 h, then cooled down to rt. The mixture was diluted with EtOAc and water. The layers were separated. The aqueous layer was extrated with EtOAc (twice). The combined organic layers were washed with brine, dried over MgS04, filtered and the solvent was removed under reduced pressure. The residue was purified by preparative LC (irregular SiOH, 15-40 muiotaeta, 220 g Grace, liquid injection (Heptane), mobile phase gradient: from Heptane 100%, to heptane 70%>, EtOAc 30%>) to give 1.91 g (37%) of intermediate (U6) as an orange oil.

The synthetic route of 4-Chloro-3-fluoroiodobenzene has been constantly updated, and we look forward to future research findings.

Synthetic Route of 202982-67-0, A common heterocyclic compound, 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, molecular formula is C6H3ClFI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 6 (100mg, 54211mo1), 35 (139mg, 54211mo1), Cs2CO3 (353mg, 1.O9mmol),Xantphos (31.4 mg, 54.2 imol) and Pd2(dba3 (49.7 mg, 54.2 Imol) in dioxane (4 mL) wasdegassed and purged with N2 for 3 times, and then the mixture was stirred at 80C for l6hrs under N2 atmosphere. LCMS showed that 6 was consumed completely. The reaction mixture was quenched by addition water (1 5inL) at rt., and then diluted with EA (1 5rnL) and extracted with EA (2OrnL x 3). The combined organic layers were washed with brine (2OrnL x 2), filteredand concentrated under reduced pressure to give a residue. The residue was purified by prep HPLC to give the desired product Compound 22 (30mg, yield: 17%).LCMS: rn/z, 312.1 (M¡ÀHi?:1H NMR (400 MHz CDC13): oe 8.58 (d, J= 44Hz, 1H), 7.67 (t. J 14Hz, 1H), 7.42 (d, J= 8Hz,1H), 7.25 (in, 211), 6.36 (in, 21-1), 3.75 (d, j:::: 8.8Hz, IH), 3.54 (d, J == S. 2Hz, 1H), 3.46 (in, 211),2.20 (m, 11-1), 1.43 (in, 21-1), 1.07 (t, J= 9.2Hz, 1Ff).

The synthetic route of 202982-67-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; DUAN, Yuejiao; SHE, Jin; WU, Chengde; (120 pag.)WO2017/71536; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H3ClFI

To a solution of 1-chloro-2-fluoro-4-iodobenzene (5.72 g, 22.67 mmol) in 1, 4-dioxane (150 mL) was added 4, 4, 5, 5-tetramethyl-2- (1, 4-dioxaspiro [4.5] dec-7-en-8-yl) -1, 3, 2-dioxaborolane (6.00 g, 22.67 mmol), Pd (dppf) Cl2 (2.47 g, 3.38 mmol) and Cs2CO3 (11.00 g, 33.83mmol) and the mixture was heated at 80 for overnight. Then evaporated the solvent under reduced pressure and the residue was purified by column chromatography (PE: EA = 20: 1) to give product as a clear oil (4.06 g in 67% yield). 1H NMR (DMSO-d6) deltaH 7.51 (t, J= 8.0 Hz, 1H), 7.46 (m, 1H), 7.28 (m, 1H), 7.12-7.20 (m, 1H), 3.91 (s, 4H), 2.51-2.56 (m, 2H), 2.34-2.40 (m, 2H), and 1.80 (t, J = 6.8 Hz, 2H).

The synthetic route of 202982-67-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BEIGENE, LTD.; WANG, Hexiang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHANG, Guoliang; ZHOU, Changyou; (353 pag.)WO2018/54365; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com