Category: 202865-85-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Bromo-4-iodo-2-methylbenzene

General procedure: To a stirred solution of 6-bromo-3-pyridyl boronic acid (1.25 equiv, 847 mg, 4.20 mmol) in 1,4-dioxane (30 mL) under nitrogen were added 5-bromo-2-iodotoluene (1 g, 3.36 mmol) and tetrakis-(triphenylphosphine)palladium(0) (0.05 equiv, 195 mg, 0.17 mmol). After 5 min of stirring, aqueous Na2CO3 (2.5 equiv, 892 mg, 8.42 mmol) in 5 mL of water was added. Then the mixture was heated to 80 C until the starting material was consumed (TLC). After cooling down to room temperature, the mixture was filtered on Celite and washed with CH2Cl2. The aqueous layer was extracted with EtOAc (2×50 mL). Combined organic layers were washed with saturated aqueous solution of NaCl (50 mL), and dried over MgSO4. Solvent was removed in vacuo and crude product was purified by column chromatography, with 99:1 cyclohexane/EtOAc affording 3c as a white solid (520 mg, 47%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 202865-85-8.

Reference:
Article; Perato, Serge; Voisin-Chiret, Anne Sophie; Sopkova-De Oliveira Santos, Jana; Legay, Remi; Oulyadi, Hassan; Rault, Sylvain; Tetrahedron; vol. 68; 7; (2012); p. 1910 – 1917;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-85-8, COA of Formula: C7H6BrI

Under an argon atmosphere, Intermediate 6 (1.20 g, 2.40 mmol),1-Bromo-4-iodo-2-methylbenzene (Intermediate 11) (852 mg, 2.88 mmol)(1.68 g, 4.80 mmol, manufactured by Wako Pure Chemical Industries, Ltd.) and copper iodide (91.4 mg, 0.48 mmol, 0.35 mmol) were added to a solution of L-proline (110 mg, 0.96 mmol; manufactured by Wako Pure Chemical Industries, : Manufactured by Wako Pure Chemical Industries, Ltd.) Dimethylformamide (2.4 ml, manufactured by Wako Pure Chemical Industries, Ltd.) was stirred under an argon atmosphere for 48 hours, At 110 CAnd heated.Next, after cooling to room temperature, a saturated aqueous solution of ammonium chloride (30 ml) and dichloromethane (100 ml) were added to the reaction mixture, followed by liquid separation. The organic layer was dried over magnesium sulfate and the residue was purified by silica gel column chromatography (dichloromethane 20%, hexane 80%) to obtain Intermediate 12 as pale yellow crystals (1.43 g, yield 89%)

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Reference:
Patent; Kokuritsu Daigaku Hojin Kyushu Daigaku; Kaji, Hironori; Suzuki, Hajime; Suzuki, Katsuaki; Oheiwa, Hajime; Wakamiya, Atsushi; Fukushima, Tatsuya; Suzuki, Huritz; Murata, Yaseujiro; Sieje, Kacheuyuki; Adachi, Jihaya; (48 pag.)KR2015/123907; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 202865-85-8

Compound K45 can be synthesized by a person of ordinary skill following Scheme 25 illustrated in FIG. 26. In the first step, compound S25-1 (available for purchase from ArkPharm, Inc., CAS No. 57103-02-3) is combined with BOC anhydride and DMAP in THF. The mixture is taken, without purification and combined with HNPh2, tBu3P, and Pd2dba3 in toluene. This mixture is taken, without purification and combined with TFA to produce compound S25-2. In the second step, compound S25-2 is combined with compound S25-3 (available for purchase from Alfa Aesar, CAS No. 202865-85-8), K3P04 and Cul in toluene at 80 C and stirred for 6 hours to form compound S25-4. In the third step, compound S25-4 is cooled to -78 C in hexanes solution before dropwise addition of nBuLi and subsequent dropwise addition of Bu3SnCl to form compound S25-5. In the fourth step, compound 25-5 is combined with compound S25-6 (available for purchase from Acros Organics, CAS No. 106-37-6) and Pd(OAc)2 in THF at 45 C and stirred for 24 hours to give compound S25-6. In the fifth step, compound S25-6 is cooled to -78 C in hexanes solution before dropwise addition of nBuLi and subsequent dropwise addition of Bu3SnCl to form compound S25-7. In the sixth step, compound S25-7 is combined with compouns S25-8 (available for purchase from eNovation Chemicals, CAS No. 40000-20-2) and Pd(OAc)2 in THF at 45 C and stirred for 24 hours to give compound K45. It is understood that steps 1, 2, 3, 4, 5, and 6 can be performed and optimized by a person having ordinary skill in the art without undue experimentation.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 202865-85-8.

Reference:
Patent; Harvard College Dean Deng; A ·asipulu-gujike; R ·gemaisi-bomubaleierli; T ·D·xiseer; J ·akuileila-aipalakuilei; R ·P·yadangsi; D ·maikelaolin; D ·K·duweinade; (333 pag.)CN106661001; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 202865-85-8

Compound K45 can be synthesized by a person of ordinary skill following Scheme 25 illustrated in FIG. 26. In the first step, compound S25-1 (available for purchase from ArkPharm, Inc., CAS No. 57103-02-3) is combined with BOC anhydride and DMAP in THF. The mixture is taken, without purification and combined with HNPh2, tBu3P, and Pd2dba3 in toluene. This mixture is taken, without purification and combined with TFA to produce compound S25-2. In the second step, compound S25-2 is combined with compound S25-3 (available for purchase from Alfa Aesar, CAS No. 202865-85-8), K3P04 and Cul in toluene at 80 C and stirred for 6 hours to form compound S25-4. In the third step, compound S25-4 is cooled to -78 C in hexanes solution before dropwise addition of nBuLi and subsequent dropwise addition of Bu3SnCl to form compound S25-5. In the fourth step, compound 25-5 is combined with compound S25-6 (available for purchase from Acros Organics, CAS No. 106-37-6) and Pd(OAc)2 in THF at 45 C and stirred for 24 hours to give compound S25-6. In the fifth step, compound S25-6 is cooled to -78 C in hexanes solution before dropwise addition of nBuLi and subsequent dropwise addition of Bu3SnCl to form compound S25-7. In the sixth step, compound S25-7 is combined with compouns S25-8 (available for purchase from eNovation Chemicals, CAS No. 40000-20-2) and Pd(OAc)2 in THF at 45 C and stirred for 24 hours to give compound K45. It is understood that steps 1, 2, 3, 4, 5, and 6 can be performed and optimized by a person having ordinary skill in the art without undue experimentation.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 202865-85-8.

Reference:
Patent; Harvard College Dean Deng; A ·asipulu-gujike; R ·gemaisi-bomubaleierli; T ·D·xiseer; J ·akuileila-aipalakuilei; R ·P·yadangsi; D ·maikelaolin; D ·K·duweinade; (333 pag.)CN106661001; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, A new synthetic method of this compound is introduced below., Computed Properties of C7H6BrI

Example 121, Step a-bPdCl2(Ph3P)2 (257 mg, 0.367 mmol) was added to a dioxane (45 mL) solution of l-bromo-4-iodo-2-methylbenzene (3.01 g, 10.13 mmol) and tri-«-butyl(l- ethoxyvinyl)stannane (3.826 g, 10.59 mmol) and heated at 80 0C for ~17 hours. The reaction mixture was treated with water (15 mL), cooled to ~0 0C (ice/water), and then NBS (1.839 g, 10.3 mmol) was added in batches over 7 minutes. After about 25 minutes of stirring, the volatile component was removed in vacuo, and the residue was partitioned between CH2Cl2 and water. The aqueous layer was extracted with CH2Cl2, and the combined organic phase was dried (MgSO4), filtered, and concentrated in vacuo. The resulting crude material was purified by a gravity chromatography (silica gel; 4% ethyl acetate/hexanes)to provide bromide 121a as a brownish-yellow solid (2.699 g); the sample is impure and contains stannane-derived impurities, among others. 1H NMR (CDCl3, delta = 7.24, 400 MHz): 7.83 (s, IH), 7.63 (s, 2H), 4.30 (s, 2H), 2.46 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/102318; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 202865-85-8,Some common heterocyclic compound, 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen atmosphere, 1-bromo-4-iodo-2-methylbenzene (1.0 g), (4-methoxyphenyl)methanethiol (520 mg) To a 1,4-dioxane solution (20 mL) containing tris (dibenzylideneacetone)dipalladium (80 mg) and 4,5-bis (diphenylphosphino) -9,9- dimethylxanthene (100 mg) wasadded diisopropylethylamine 1.2 mL) was added, and the mixture was reacted under reflux for90 minutes. The reaction mixture was cooled, water was added, and the mixture was extractedtwice with ethyl acetate (30 mL). The organic layer was washed with saturated brine, dried overanhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtainedresidue was purified by column chromatography (heptane: ethyl acetate = 20: 1) to obtain (4 -bromo-3-methylphenyl) (4-methoxybenzyl) sulfane (907 mg, yield 83%) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-iodo-2-methylbenzene, its application will become more common.

Reference:
Patent; Ishihara Sangyo Co., Ltd.; Ueki, Toshihiko; Yamada, Ryu; Izakura, Kenji; (30 pag.)JP2017/75131; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 202865-85-8 as follows. Recommanded Product: 1-Bromo-4-iodo-2-methylbenzene

General procedure: General Procedure A: (0312) A mixture of an arylbromide or aryliodide (1 mmol), an arylboronic acid, aryldioxaborolane or bis(pinacolato)diboron (1.5 mmol), a palladium catalyst (0.1 mmol) and K2CO3 (2-3 mmol) was placed in a reaction vessel which was then thoroughly purged with argon. Dioxane (3 mL) and water (1.5 mL) were added, and the mixture was stirred at 80-95 C. for 1 to 4 h. After cooling to rt, the mixture was poured into EtOAc/H2O (1:1, 10 mL) and the aqueous layer was extracted with EtOAc (5 mL×2). The combined organic extracts were dried (Na2SO4), filtered and concentrated under reduced pressure. Purification of the resultant residue by silica gel chromatography (EtOAc/heptanes) afforded the desired biaryl product.

According to the analysis of related databases, 202865-85-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Janssen Pharmaceutica NV; Meegalla, Sanath; Player, Mark R.; Huang, Hui; Winters, Michael P.; (98 pag.)US2017/291908; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 202865-85-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

1-bromo-4-iodo-2-methylbenzene (12.5 g) and tert-butyl 5-hydroxy-4-methyl-2,3-dihydro-1H-indole-1-carboxylate (7.00 g) in dioxane (250 mL) solution, copper iodide (I) (107mg), N,N-dimethylglycine (116 mg) and cesium carbonate (18.3 g) was added, stirred for 5 hours and 30 minutes at 100C. Allowed to stand overnight, After cooling to room temperature, and stirred for 9 hours at again 100C, the reaction solution was filtered through Celite. The obtained filtrate was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (dichloromethane/hexane) to give the title compound (5.26 g) as a colorless solid.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-iodo-2-methylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DAIICHI SANKYO COMPANY LIMITED; NAGAMOCHI, MASATOSHI; GOTANDA, KENTOKU; NOGUCHI, TETSUJI; GOTO, TAIJI; SASAKI, JUNKO; TORIHATA, MUNEFUMI; YOSHINO, TOSHIHARU; ISOBE, TAKASHI; (97 pag.)JP2016/108257; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 202865-85-8

Carbazole (1.67 g, 10 mmol), 2-bromo-5-iodobenzene (1.57 ml, 2.07 g/mL, 11 mmol), cuprous iodide(0.38 g, 0.2 mmol) and sodium tert-butoxide (1.92 g, 20 mmol) were added to the reaction flask, and nitrogen gas was exchanged three times (10 min/time), and the solvent (1,4-dioxane) was injected under a nitrogen atmosphere. After the raw material is partially dissolved, 2 ml of 1,2-diaminocyclohexane is injected (withAfter the injection, the reaction was refluxed at 110 C for 6 h, extracted, concentrated, and powdered, and purified by column chromatography to obtain a white solid product 2 in a yield of 70%.

The synthetic route of 202865-85-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; South China University of Technology; Tang Benzhong; Zhao Zujin; Hu Shimin; Qin Anjun; Hu Rongrong; Wang Zhiming; (24 pag.)CN109593079; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, A new synthetic method of this compound is introduced below., Product Details of 202865-85-8

Example N22, Step aA solution of l-bromo-4-iodo-2-methylbenzene (5.0 g, 16.83 mmol) in dioxane (75 mL) was purged with 2 for 10 minutes. Then PdCl2(Pli3P)2 (428 mg 0.609 mmol) and tri-n-butyl(l-ethoxyvinyl)stanane (5.94 mL, 17.59 mmol) was added, and the reaction mixture was purged with 2 for 10 minutes and heated at 80 C for overnight. Water (25 mL) was added to the reaction mixture and cooled to 0 C, NBS (3 g, 17.1 mmol) was added and the mixture was stirred for 30 minutes. The volatile component was removed under reduced pressure, and water was added to the resulting residue and it was extracted with DCM (3 x 100 mL). The combined organic extract was dried over Na2S04 and concentrated in vacuo. The crude was purified by flash chromatography (ISCO; EtOAc: petroleum ether, 2:98) to afford ketone N22a (2.6 g). ¾ NMR (CDCI3, delta = 7.26 ppm, 400 MHz): delta 7.84 (d, J = 0.8, 1H), 7.65-7.62 (m, 2H), 4.32 (s, 2H), 2.48 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; HEWAWASAM, Piyasena; WO2012/39717; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com