Category: 19821-80-8

Electric Literature of 19821-80-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19821-80-8 name is 1,3-Dibromo-2-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

At -75 C butyllithium (14 mmol) in hexanes (5.6 mL) was added to a solution of 1,3-dibromo-2-iodobenzene (4.3 g, 12 mmol) in diethyl ether (0.18 L). After the solution was stirred for 2 h at -75 C, copper(II)chloride (9.7 g, 72 mmol) was added, and the reaction mixture was allowed to attain 25 C over a 12 h period. Cold water was added to the reaction mixture and the organic layer was separated. The aqueous phase was extracted with ethyl acetate (2×0.10 L). The combined organic layers were dried over sodium sulfate before being evaporated. 2,2′,6,6′-tetrabromo-1,1′-biphenyl precipitates upon treatment of the residue with hexanes cooled to -20 C. The product is pure enough for further reaction; m.p. 214 – 215 C; 9.0 g (33%);1H NMR (CDCl3, 400 MHz): delta = 7.67 (d, J= 8.3 Hz, 4 H), 7.17 (t, J = 8.0 Hz, 2 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dibromo-2-iodobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Lonza AG; EP1609795; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19821-80-8, Product Details of 19821-80-8

50 g (138 mmol) of 1,3-dibromo-2-iodobenzene was added to a 1 L 3-neck round-And 1.3 g (6.9 mmol) of copper iodine,3.2 g (2.8 mmol) of Pd (PPh3) 4 is added and dissolved in 200 ml of triethylamine.After dissolving all the reactants, 17.5 g (171 mmol) of phenylacetylene was added under nitrogenSlowly add to the dropping funnel and stir at room temperature for 4 hours.After completion of the reaction, dilute 500 ml of normal hexane. Filter the reaction mixture into a Buchner vacuum funnel filled with 200 g of silica gel, remove the catalyst and salts, and wash with 1 L of n-hexane. The yellow oil is obtained by removing all the solvent of the filtered solution. (40 g, 86% yield)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dibromo-2-iodobenzene, and friends who are interested can also refer to it.

Reference:
Patent; SFC Ltd.; Che Jong-tae; Choi Seong-geun; Kim Nam-i; Kim Hui-dae; (73 pag.)KR101923936; (2018); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19821-80-8, name is 1,3-Dibromo-2-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 19821-80-8

Synthesis Example 2 (Synthesis of 2,6-Dimesityliodobenzene) A solvent of 200 mL of THF was added to 6.0 g (250 mmol) of magnesium (Wako Pure Chemical Industries, Ltd.) and a trace amount of iodine. In 100 mL of THF was dissolved 34 mL (225 mmol) of bromomesitylene (Wako Pure Chemical Industries, Ltd.). The solution was added dropwise to the above magnesium/THF slurry at room temperature in 2 hours. After the completion of the dropping, the solution was refluxed for 2 hours, and then cooled to room temperature. In 50 mL of THF was dissolved 23 g (64 mmol) of 1,3-dibromoiodobenzene. The solution was added dropwise to the above Grignard solution at room temperature in 1 hour. The reaction liquid was refluxed for 3 hours, and then cooled to 0C. A solution of 25 g (100 mmol) of iodine in 50 mL of THF was added dropwise to the reaction mixture, followed by warming to room temperature. The reaction mixture was washed with a saturated aqueous solution of sodium sulfite, and then extracted three times with diethyl ether. The ether layers were mixed, then washed with water and saturated brine, and then dried with magnesium sulfate. The solvent was removed under reduced pressure, and the byproduct was then removed under reduced pressure. The residue was recrystallized from methanol, giving 19.7 g of white solid of 2,6-dimesityliodobenzene (70% in yield). It was confirmed that the product was 2,6-dimesityliodobenzene by 1H-NMR. 1H-NMR (400MHz, CDCl3) 1.98 (s, 12H, o-CH3), 2.35 (s, 6H, p-CH3), 6.96 [s, 4H, m-H (Mes)], 7.08 [d, J = 7.6 Hz, 2H, m-H (Ph)], 7.46 [t, J = 7.6 Hz, 1H, p-H (Ph)].

The synthetic route of 19821-80-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Otsuka Chemical Holdings Co., Ltd.; EP2133357; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 19821-80-8, A common heterocyclic compound, 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, molecular formula is C6H3Br2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,6-dibromoiodobenzene (1.0 g, 2.8 mmol), 1-naphthaleneboronic acid (0.48 g, 2.8 mmol),Tetrakis(triphenylphosphine)palladium (0.33 g, 0.28 mmol), lithium hydroxidemonohydrate (0.46 g, 11 mmol) were charged into a flask, and purged 3 times with nitrogen,the degassed acetonitrile (100 mL) and degassed water (10 mL) were added, and stirred at 70C for 14 hunder nitrogen atmosphere. The reaction mixture was cooled to room temperature and diluted with EtOAcand H2O, then separated and the organic layer was dried over Na2SO4 and concentrated under reducedpressure. The residue was purified by column chromatography on silica gel to give the desired product(0.69 g, 69%). 1H NMR (500 MHz, CDCl3): 7.95-7.91(m, 2H), 7.71 (d, J = 8.0 Hz, 2H), 7.58 (t, J = 8.0Hz, 1H), 7.51 (t, J = 8.0 Hz, 1H), 7.43 (t, J = 8.0 Hz, 1H), 7.34-7.30 (m, 2H), 7.18 (t, J = 8.0 Hz, 2H);13C NMR (125 MHz, CDCl3) 141.5, 138.9, 133.5, 131.9, 130.9, 130.2, 128.6, 128.5, 127.0, 126.5, 126.1,125.5, 125.4, 124.9; HRMS (EI-TOF): Calcd for C16H10Br2, 359.9149; found 359.9152.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhou, Haifeng; Uozumi, Yasuhiro; Synlett; vol. 24; 19; (2013); p. 2550 – 2554;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19821-80-8, category: iodides-buliding-blocks

EXAMPLE 1; Preparation of 5-Bromo-9-isopropylidene-benzonorbornadiene (Compound No. 5.12); a) »-ButvUithium variant, from l,3-dibromo-2-iodo-benzene; To a stirred solution of l,3-dibromo-2-iodo-benzene (5.0Og, 13.8 mmol) and 6,6- dimethylfulvene (7.57g, assay 97%, 69 mmol) in dry toluene (60 ml) under a nitrogen atmosphere 5.5 ml of a 2.5M toluene solution of n-butyllithium (14.5 mmol) were added dropwise at O0C within 10 minutes. After a further 10 minutes at O0C and 1 hour at ambient temperature, the reaction mixture was poured onto a saturated aqueous solution of ammonium chloride, extracted with ethyl acetate, washed with brine and water, dried over sodium sulphate and evaporated. Purification of the crude material on silca gel in hexane afforded 2.55g of the desired product as a yellow oil (assay 99% by g.l.c, 70% yield). Yellow crystals of m.p. 90-910C were obtained from cold hexane.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/68417; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 19821-80-8, A common heterocyclic compound, 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, molecular formula is C6H3Br2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Place 3-mercaptoindole (25g, 1eq), 1,3-dibromo-2-iodobenzene (60.62g, 1eq), cesium carbonate Cs2CO3(109.18g, 6eq)in a dry two-necked bottleWith a small amount of copper flakes (3.47g, 0.001eq), then add 250mL of dimethylformamide, warmed to 130 for 24 hours, the solvent was distilled off in vacuo, and then dichloromethane and water, the dichloromethane layer After drying with magnesium sulfate, spin-dry it, and then use silica gel column to separate and purify.The solid was obtained as an intermediate (Ir-072-a) with a yield of 83%.

The synthetic route of 19821-80-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Huarui Optoelectric Materials Co., Ltd.; Liang Zhiming; Yan Caijuan; Huang Hong; Pan Junyou; Chen Sihang; (52 pag.)CN111039987; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 19821-80-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19821-80-8 name is 1,3-Dibromo-2-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

By following the general process but using the B2Pin2, [Ir(OMe) (COD)]2, under dtbpy borylation conditions, 3,5-dibromo-4-iodophenol was made from 2-iodo-1,3-bromobenzene with 92% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dibromo-2-iodobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Board of Trustees of Michigan State University; US2004/30197; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19821-80-8, Safety of 1,3-Dibromo-2-iodobenzene

Example 2: 2,2′,6,6′-Tetrabromo-l,l’-biphenyI (III); At -75 C butyllithium (14 mmol) in hexanes (5.6 mL) was added to a solution ofl,3-dibromo-2-iodobenzene (4.3 g, 12 mmol) in diethyl ether (0.18 L). After the solutionwas stirred for 2 h at -75 C, copper(II)chloride (9.7 g, 72 mmol) was added, and thereaction mixture was allowed to attain 25 C over a 12 h period. Cold water was added tothe reaction mixture and the organic layer was separated. The aqueous phase was extractedwith ethyl acetate (2×0.10 L). The combined organic layers were dried over sodium sulfatebefore being evaporated. 2,2′,6,6′-tetrabromo-l,l’-biphenyl precipitates upon treatment ofthe residue with hexanes cooled to -20 C. The product (9.0 g, 33%) is pure enough forfurther reaction;m.p. 214-215 C;.H NMR (CDC13, 400 MHz): 8 = 7.67 (d, J- 8.3 Hz, 4 H), 7.17 (t, J- 8.0 Hz, 2 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19821-80-8 as follows. Recommanded Product: 1,3-Dibromo-2-iodobenzene

General procedure: 10.0 grams (g) (27.6 millimoles, mmol) of 1,3-dibromo-5-iodobenzene, 4.06 g (27.6 mmol) of (2-cyanophenyl)boronic acid, 1.60 g (1.38 mmol) of tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4), and 9.55 g (69.1 mmol) of potassium carbonate were added to a mixed solution containing 60 milliliters (mL) of tetrahydrofuran (THF) and 30 mL of water, and the reaction mixture was stirred for 12 hours under reflux. After the reaction was completed, the reaction product was cooled to room temperature, and the aqueous solution layer was removed therefrom through extraction. The resultant obtained therefrom was filtered through a silica gel under reduced pressure, and the filtrate was concentrated under reduced pressure. The product obtained therefrom was separated by silica gel column chromatography to provide Intermediate (A) (4.38 g, yield of 47%).

According to the analysis of related databases, 19821-80-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung Electronics Co., Ltd.; Samsung SDI Co., Ltd.; JUNG, Yongsik; JEON, Soonok; KWON, Eunsuk; KIM, Sangmo; KIM, Juhyun; SON, Jhunmo; CHUNG, Yeonsook; KIM, Joonghyuk; (327 pag.)US2020/31812; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 19821-80-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19821-80-8, name is 1,3-Dibromo-2-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 1,3-dibromo-2-iodobenzene of example 1 (13.7 g, 37.9 mmol, 1 eq) in tetrahydrofuran (160 mL) at -100 C. tert-butyllithium (75.9 mmol, 2 eq) in pentane (44.6 mL) was slowly added in the course of 3 h. After additional 1 h, 1,2-dibromobenzene (8.94 g, 4.57 mL, 37.9 mmol) was added dropwise and the reaction mixture was then allowed to reach 25 C. After 15 h, distilled water (150 mL) was added, followed by extraction with ethyl acetate (3¡Á150 mL). The combined organic layers were dried, filtered and evaporated. The residue was purified by flash chromatography which afforded 2,2′,6-tribromobiphenyl (12.9 g, 33 mmol, 97%) as white needles; m.p. 95-97 C.-1H NMR (400 MHz, CDCl3): delta=7.69 (1 H, d, J=8.1 Hz), 7.64 (2 H, dd, J=8.1, 0.7 Hz), 7.42 (1 H, tt, J=7.5, 0.9 Hz), 7.29 (1 H, ddt, J=7.8, 1.8, 0.7 Hz), 7.18 (1 H, dd, J=7.6, 1.6 Hz), 7.12 (1 H, dd, J=8.1, 0.7 Hz). -13C NMR (101 MHz, CDCl3): delta=142.2, 141.9, 132.6, 131.4, 130.6, 130.3, 129.8, 127.4, 124.4, 123.3. -C12H7Br3 (390.7): calculated C 36.87%, H 1.81%; found C 36.82%, H 1.66%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-2-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Leroux, Frederic; Bonnafoux, Laurence; Colobert, Francoise; US2010/137659; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com