Category: 19393-94-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19393-94-3 as follows. Quality Control of 2,4-Dibromo-1-iodobenzene

Synthesis of Intermediate A2; Intermediate A1 (2.5 g, 6.9 mmoles), 1-pyreneboronic acid (1.7 g, 6.9 mmoles) and tetrakis(triphenylphosphine)palladium(0) (0.24 g, 0.21 mmoles, 3% Pd) were suspended in 1,2-dimethoxyethane (20 mL) under a nitrogen atmosphere, to which was then added a 2M sodium carbonate aqueous solution (2.2 g, 21 mmoles, 3 eq./10 mL), and the mixture was refluxed for 10 hours. Toluene (150 mL) and water (50 mL) were added to the reaction mixture, an organic layer was aliquoted, washed with saturated salt water (50 mL) and then dried over anhydrous magnesium sulfate, and the solvent was distilled off to obtain a pale yellow solid. This was purified by means of column chromatography (silica gel/hexane and 17% dichloromethane) to obtain a white solid (1.9 g, 63%). 1H-NMR (400 MHz, CDCl3, TMS): delta7.32 (1H, d, J = 8 Hz), 7.60 (1H, dd, J = 8 Hz, 2 Hz), 7.68 (1H, d, J = 9 Hz), 7.83 (1H, d, J = 8 Hz), 7.96 to 8.02 (3H, m), 8. 10 (2H, s), 8.16 (1H, d, J = 8 Hz), 8.20 (1H, d, J = 8 Hz), 8.21 (1H, d, J = 8 Hz)

According to the analysis of related databases, 19393-94-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2316816; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 19393-94-3, name is 2,4-Dibromo-1-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19393-94-3, Computed Properties of C6H3Br2I

General procedure: An oven-dried Schlenk tube was charged with a magneticstir bar, binucleophile 2-mercaptobenzimidazole 2 (1.0 mmol, 1.0 equiv), CuI(0.1 mmol, 10 mol %), phen (0.2 mmol, 20 mol %), and K2CO3 (2.0 mmol, 2equiv). The tube was capped and then evacuated and backfilled with nitrogen(3 times). Under a positive pressure of nitrogen, a solution of o-dihaloarene 1(1.05 mmol, 1.05 equiv) in DMF (3 mL) was added via syringe. The tube wassealed and allowed to stir at 120 C (monitored by TLC). After being cooled toroom temperature, EtOAc (40 mL) was added and the mixture was washedwith brine (20 mL 3). The organic phase was dried over Na2SO4 andconcentrated. The residue was purified by column chromatography on silicagel using petrol/EtOAc (10:1?3:1, v:v) as eluent to give product 3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dibromo-1-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Gao, Jilong; Zhu, Jiaoyan; Chen, Lubin; Shao, Yingying; Zhu, Jiaqi; Huang, Yijia; Wang, Xiaoxia; Lv, Xin; Tetrahedron Letters; vol. 55; 22; (2014); p. 3367 – 3373;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 19393-94-3,Some common heterocyclic compound, 19393-94-3, name is 2,4-Dibromo-1-iodobenzene, molecular formula is C6H3Br2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 30.0 g of intermediate 1-1,500 ml of N,N-dimethylformamide to a 1 L three-necked flask, and replace the nitrogen gas. Then added 75.3 g of intermediate 1-2, 57.5 g of potassium carbonate, 1.2 g of bis(2-diphenylphosphinophenyl) ether, 2.4 g of palladium acetate; The reaction solution was heated to 150 C, and the reaction was stirred for 24 hours. The reaction was stopped after TLC was monitored to complete the reaction. After the reaction solution was cooled to room temperature, it was poured into 1.5 L of water to precipitate a solid. After washing with water to neutral, the crude product was passed through a column, and toluene was recrystallized to give 42.4 g of intermediate 1 in a yield of 68.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Dibromo-1-iodobenzene, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 19393-94-3, name is 2,4-Dibromo-1-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19393-94-3, COA of Formula: C6H3Br2I

Into a 100ml two-necked flask feed 2, 4-dibromo-1-iodobenzene (3.6g), trimethylsilylacetylene (1. 1g), CuI (O.11g), Pd(PPh3)2C12 (0.21g) molar ratio is based on 1:1.1 :0.06:0.03, solvent selection as 50ml anhydrous tetrahydrofuran, anhydrous anaerobic conditions are controlled at 0 C, stir for 30 minutes, distillation under reduced pressure and then obtained 3.16g of ((2,4-dibromophenyl) ethynyl) trimethylsilane, yield is 95%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dibromo-1-iodobenzene, and friends who are interested can also refer to it.