Category: 19231-06-2

Application of 19231-06-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19231-06-2 name is Bis(4-methoxyphenyl)iodonium bromide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

107.2 g obtained in step (1) was added to the reactor.3,5-diiodo-L-tyrosine copper complex and 1000 ml of water,Then slowly add 1200ml of n-butanol to the inside.After the dropwise addition within 1 h, the reaction was dissolved. Then add 43.8g of diisopropylamineThereafter, 146 g of diphenyl methyl ether iodide bromide was further added. The reaction solution was heated to 90 C, and reacted at 90 C for 2 h, cooled to room temperature, and 280 ml of toluene was added. An additional 200 ml of 10% citric acid solution was added and stirred at room temperature for 2 h, filtered, washed with water and methyl isobutyl ketone. The obtained wet cake was further added with 400 ml of 10% citric acid solution and stirred for 1 h, filtered, and washed with 10% citric acid solution.Drying to give 2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propionic acid (compound of formula III) 69.1 g,The yield was 59.3%, and it was used.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Bis(4-methoxyphenyl)iodonium bromide, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Tech University; Lu Dingqiang; Chen Li; Wang Xinxian; Ye Hui; (10 pag.)CN109810009; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 19231-06-2, name is Bis(4-methoxyphenyl)iodonium bromide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19231-06-2, Recommanded Product: 19231-06-2

295 parts of the salt represented by the formula (I-17-a)88.25 parts of the compound represented by the formula (I-17-b) and 750 parts of chloroform,And the mixture was stirred at 23 C. for 1 hour.After concentrating the obtained reaction solution, to the obtained residue,1000 parts of tert-butyl methyl ether was added and stirred,By filtration, 328 parts of a salt represented by the formula (I-17-c) was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Bis(4-methoxyphenyl)iodonium bromide, and friends who are interested can also refer to it.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; ICHIKAWA, KOJI; FUJITA, SHINGO; ANRYU, YUKAKO; (69 pag.)JP6252292; (2017); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19231-06-2, name is Bis(4-methoxyphenyl)iodonium bromide, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

5.00 parts of the compound represented by the formula (I-2-a) and 25 parts of acetonitrile,After stirring at 23 C. for 30 minutes,2.49 parts of silver oxide was charged,After stirring at 23 C. for 1 hour,It was filtered.9.08 parts of the compound represented by the formula (I-2-c) was charged in the recovered filtrate,Followed by stirring at 23 C. for 12 hours.After filtering the obtained reaction mass,The collected filtrate was concentrated.To the collected residue,100 parts of chloroform and 35 parts of ion exchanged water were added and stirred at 23 C. for 30 minutes,The liquid was separated and the organic layer was taken out.Ion exchanged water (35 parts) was added to the recovered organic layer, and the mixture was stirred at 23 C. for 30 minutes,The liquid was separated and the organic layer was taken out.This washing operation was repeated 5 times.After concentrating the obtained organic layer,To the obtained residue,After adding 50 parts of tert-butyl methyl ether and stirring,By filtration, 11.69 parts of a salt represented by the formula (I-2-d) was obtained.

The synthetic route of 19231-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; YOSHIDA, ISAO; ICHIKAWA, KOJI; (76 pag.)JP6244891; (2017); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19231-06-2, name is Bis(4-methoxyphenyl)iodonium bromide, A new synthetic method of this compound is introduced below., Application In Synthesis of Bis(4-methoxyphenyl)iodonium bromide

Each of the four bis(4-methoxyphenyl)iodonium halides (fluoride, chloride, bromide, iodide) (10 mg) was suspended in C6D6, sealed in a J. Young NMR tube, and heated at 120 C for the times indicated: (fluoride, 2.5 hours; chloride, 5 days; bromide, 5 hours, iodide, 2.5 hours). The reactions were followed by FontWeight=”Bold” FontSize=”10″ H NMR spectroscopy and were deemed completed when a homogeneous solution containing no trace of the diaryliodonium salt starting material was obtained. Representative FontWeight=”Bold” FontSize=”10″ H NMR spectra obtained at the completion of reactions are show in FIG. 1. Different reactivity modes are observed across the series of halides. Thermal decomposition of the diaryliodonium fluoride in d6-benzene gave mostly 4-fluoroanisole and a small amount of 3-fluoroanisole. This side product probably arises from a competing mechanism that involves a benzyne intermediate formed by ortho-proton extraction by the hard base fluoride under these conditions. In contrast, chloride and bromide reacted to provide the corresponding 4-haloanisole in quantitative yield; no 3- halo regioisomers were produced. This can be explained easily; the basicity of chloride and bromide are not high enough to promote benzyne formation by proton abstraction. In contrast to these three reactions, which appear to proceed through two-electron intermediates, the thermal decomposition of bis(4-methoxyphenyl)iodonium iodide produces 4,4′-dimethoxy-biphenyl, h, and an unidentified arene product in addition to the 4-iodoanisole. The biphenyl and h probably result from the formation of free radical intermediates.

The synthetic route of 19231-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NUTECH VENTURES; DIMAGNO, Stephen; HU, Bao; WO2015/147950; (2015); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com