Category: 19099-54-8

Adding a certain compound to certain chemical reactions, such as: 19099-54-8, name is 1-Iodo-2-isopropylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19099-54-8, Computed Properties of C9H11I

A solution of 2-iodoisopropylbenzene (4.0 g, 16.3 mmol), concentrated sulfuric acid (4.6 rnL), and 60% nitric acid (1.5 g, 24.5 mmol) in chloroform (12 mL) was stirred at room temperature for 16 h. The reaction mixture was concentrated and purified using flash chromatography (SiO2, hexanes-ethyl acetate) to afford the title compound as a yellow liquid (1.7 g, 36%).[0241] 1H NMR (500 MHz, DMSO-J6): delta 1.24 (d, J = 6.8 Hz, 6H), 3.17-3.23 (m, IH), 7.76 (dd, J = 6.6, 2.5 Hz, IH), 8.04 (d, J= 2.8 Hz, IH), 8.15 (d, J= 8.5 Hz, IH)

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Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 19099-54-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19099-54-8, name is 1-Iodo-2-isopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

In a dry 25 mL Schlenk reaction tube, 74 mg of 2-isopropyl iodobenzene, 203 mg of benzoic anhydride, 71 mg of benzoxazole, 5.3 mg of palladium chloride,14 mg of tris(2-furyl)phosphine, 43 mg of copper bromide, 56 mg of norbornene, 124 mg of potassium carbonate, and 3 mL of acetonitrile.Under nitrogen atmosphere, stirring was performed at 100C for 16 hours.After the reaction was completed, the mixture was cooled to room temperature and insoluble material was removed by filtration and passed through a silica gel column (volume ratio of ethyl acetate to petroleum ether was 1:10) to obtain 136 mg of a product in a yield of 40%. The reaction process was as shown in the following formula:

The chemical industry reduces the impact on the environment during synthesis 1-Iodo-2-isopropylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zhejiang University; Chen Wanzhi; Zhang Pingshun; Pan Shanfei; (24 pag.)CN107382894; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19099-54-8, name is 1-Iodo-2-isopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 19099-54-8

0.3 mmol of sodium carbonate and 0.1 mmol of 1,2-bis(4-methoxyphenyl)acetylene,Tetrakis(triphenylphosphine palladium) 0.005 mmol, bis(2-diphenylphosphinophenyl)ether 0.005 mmol,0.2 mmol of 4-methylbenzeneboronic acid, 0.3 mmol of 2-isopropyliodobenzene, and 1 mL of N,N-dimethylformamide were added to a 15 mL reaction tube.Nitrogen was repeatedly filled 10 times, placed in an oil bath at 120 C, and reacted for 24 hours;Cooled to room temperature, the reaction was diluted with ethyl acetate, washed with water three times, the organic phase dried over anhydrous Na2SO4, filtered, and concentratedPurification by thin layer chromatography to give 34.9mg of the desired product, yield 78%.

According to the analysis of related databases, 19099-54-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Huaqiao University; Cheng Guolin; Lv Weiwei; (20 pag.)CN109879713; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 19099-54-8,Some common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, molecular formula is C9H11I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a 5 mL flask, the catalyst MgO(at)PdCu (10 mg for ArI or 40 mgfor ArBr and ArCl), ArX (1 mmol), DABCO (168 mg, 1.5 mmol), andTBAB (322 mg, 1 mmol), for aryl chloride and DMF (2 mL) wereadded under argon atmosphere. The alkyne (1.5 mmol) was alsoadded and the resulting mixture was stirred at 60-120 C forappropriate reaction times (see Tables). Progress of reactions wasfollowed by GC. Then, the reaction mixture was cooled down toroom temperature and extracted with ethyl acetate (3 x 5 mL), the organic phase was washed with H2O (10 mL), dried and evaporated.The resulting residue was purified by column or plate chromatographyusing hexane and ethyl acetate as eluents.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-2-isopropylbenzene, its application will become more common.

Reference:
Article; Gholinejad, Mohammad; Bahrami, Maedeh; Najera, Carmen; Pullithadathil, Biji; Journal of Catalysis; vol. 363; (2018); p. 81 – 91;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 19099-54-8

0.3 mmol of sodium carbonate and 0.1 mmol of 1,2-bis(4-methoxyphenyl)acetylene,Tetrakis(triphenylphosphine palladium) 0.005 mmol, bis(2-diphenylphosphinophenyl)ether 0.005 mmol,0.2 mmol of [1,1′-biphenyl]-4-ylboronic acid, 0.3 mmol of 2-isopropyliodobenzene, and 1 mL of N,N-dimethylformamide were added to a 15 mL reaction tube.Nitrogen was repeatedly filled 10 times, placed in an oil bath at 120 C, and reacted for 24 hours;Cooled to room temperature, the reaction was diluted with ethyl acetate, washed with water three times, the organic phase dried over anhydrous Na2SO4, filtered, and concentratedPurification by thin layer chromatography to give 30.6mg of the desired product in 60% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19099-54-8.

Reference:
Patent; Huaqiao University; Cheng Guolin; Lv Weiwei; (20 pag.)CN109879713; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com