Category: 19094-48-5

Discovery of 3,5-Diiodobenzoic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19094-48-5, its application will become more common.

Some common heterocyclic compound, 19094-48-5, name is 3,5-Diiodobenzoic acid, molecular formula is C7H4I2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 19094-48-5

Step 2: Methyl 3,5-diiodobenzoate (YZ-I-93) To a solution of 3,5-diiodobenzoic acid (6.8 g, 18.18 mmol) in methanol (200.0 ml) was added CH3SO3H (0.5 ml). The reaction mixture was heated to reflux. After refluxing for 7.5 hours, most of the methanol was removed. Then, water (200.0 ml) was added and a dark-brown solid was collected by filtration. The product was purified by silica gel column chromatography using hexanes/ethyl acetate (8:2) as eluent. The final pure white product was obtained in the amount of 4.2 g (59.2%) by recrystallization from methanol/water: 1H NMR (CDCl3): delta 8.29 (d, 2HBz, J=1.6 Hz), 8.20 (t, 1HBz, J=1.6 Hz), 3.90 (s, 3H, OCH3). 13C NMR (CDCl3): delta 163.97, 148.99, 137.56, 133.08, 94.32, 52.73.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19094-48-5, its application will become more common.

Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; US2010/331509; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New downstream synthetic route of 19094-48-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19094-48-5, its application will become more common.

Some common heterocyclic compound, 19094-48-5, name is 3,5-Diiodobenzoic acid, molecular formula is C7H4I2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 19094-48-5

S3.ll: To a solution of S3.10 (6.8 g, 18 mmol) in methanol (200 mL) was added sulfuric acid (0.5 mL). The reaction mixture was refluxed for 7.5 hours, then after cooling concentrated and deionized water (200 mL) was added. A dark-brown solid was collected by filtration and purified by column chromatography (silica gel; hexanes:ethyl acetate = 8:2). The product was obtained as a white powder, 4.2 g (59.2%), by recrystallization from methanol/water. NMR (300 MHz, CDC13): delta 8.29 (d, J= 1.6 Hz, 2H), 8.20 (t, J= 1.6 Hz, 1H), 3.90 (s, 13 delta 163.97, 148.99, 137.56, 133.08, 94.32, 52.73.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19094-48-5, its application will become more common.

Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; ZUNIGA, Carlos; MARDER, Seth; HASKE, Wojciech; KIPPELEN, Bernard; FENG, Daijun; WO2014/11491; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com