Category: 188057-20-7

Boyle, Benjamin T.; Koniarczyk, J. Luke; McNally, Andrew published the artcile< Facile Pyridine SNAr Reactions via N-Phosphonium-Pyridinium Intermediates>, Safety of 4-Iodopyridin-3-ol, the main research area is pyridine nucleophilic aromatic substitution reaction halopyridine phosphine; phosphonium pyridinium intermediate; SNAr reaction; phosphonium salts; pyridines; pyridinium salts.

Here we report that N-phosphonium pyridinium intermediates are unusually reactive for pyridine SNAr reactions. Specifically, forming phosphonium salts from halopyridines typically requires elevated temperatures and Lewis acid additives. The alternative activation mode described in this paper permits C-P bond formation to occur at ambient temperatures in many cases, and functions across a broad range of substrates.

Synlett published new progress about Nucleophilic aromatic substitution reaction. 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Safety of 4-Iodopyridin-3-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sakurai, Yohji published the artcile< Tandem Sonogashira-Hagihara coupling/cycloisomerization reactions of ethynylboronic acid mida ester to afford 2-heterocyclic boronic acid mida esters: a concise route to benzofurans, indoles, furopyridines and pyrrolopyridines>, COA of Formula: C5H4INO, the main research area is Sonogashira Hagihara coupling cycloisomerization ethynylboronic mida ester; heterocyclic boronic mida preparation conversion benzofuran indole furopyridine pyrrolopyridine.

A one-pot process that provides direct access to 2-heterocyclic MIDA (N-methyliminodiacetic acid) boronates has been developed. The reaction of 2-iodophenols or 2-iodoanilines with ethynylboronic acid MIDA ester readily afforded 2-substituted heterocyclic compounds Amidine and phosphazene bases, especially TMG (1,1,3,3-tetramethylguanidine) assumed an important role in the tandem Sonogashira-Hagihara coupling/cycloisomerization reactions.

Heterocycles published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, COA of Formula: C5H4INO.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com