Category: 1878-94-0

1878-94-0, Name is 2-(4-Iodophenoxy)acetic acid, 1878-94-0, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

3-[2-(4-iodo-phenoxy)acetyl-amino]-benzamideTo (4-iodo-phenoxy)-acetic acid (83.5 mg, 0.3 mmol), 3-aminobe?zamide (61.3 mg, 0.45 mmol), N- (3-dimethylaminopropyl)-N-ethyl carbodmideHCl (EDC) (86.3 mg, 0.45 mmol) and 1-hydroxybenzotriazole (HOBt) (61.3 mg, 0.45 mmol) in DMF (3 ml) was added N, N-dsopropylethyamine, redistilled (DIPEA) (0.08 ml, 0.45 mmol). The mixture was stirred overnight, and then partitioned between ethyl acetate and water. The organic phase was washedwith brine, dried (MgSC>4 anh), and concentrated. The residue was purified by silica gel flash column chromatography (CH2CHkMeOH = 6: 1) to give 3-[2-(4-iodo-phenoxy)acetyl-amino]-benzamide as a white solid (105.1 mg, 88.4% yield). 1H-NMR (DMSOKI6) 10.22 (IH, s, NH), 8.09 (IH, s, aromatic-H), 7.94(1H, s, NH2), 7.79 (IH, d, J =8.1 Hz, aromatic-H), 7.56 – 7.64 (3H, m, aromatic-H), 7.35 – 7.41 (2H, m, aromatic-H, NH2), 6.86 (2H, d, J= 8.7 Hz, aromatic-H), 4.71 (2H5 S3 CH2)., ..

Statistics shows that 2-(4-Iodophenoxy)acetic acid is playing an increasingly important role. we look forward to future research findings about 1878-94-0.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; WO2008/4798; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1878-94-0,Some common heterocyclic compound, 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, molecular formula is C8H7IO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An equimolar mixtures of 4-amino-6-tert-butyl-3-mercapto-1,2,4-triazine-5(H)-one (0.01mol) (3) and substituted aryloxyacetic acids (0.01mol) (4) were condensed in presence of POCl3 at 90C, for 8h. The reactions were carried out in dry condition. The reaction mixtures were cooled and poured into crushed ice drop wise with vigorous shaking, yielded solid product, filtered and recrystallized from ethanol to afford analytical samples (5a-5n) (Scheme 2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Iodophenoxy)acetic acid, its application will become more common.

Reference:
Article; Castelino, Prakash Anil; Naik, Prashantha; Dasappa, Jagadeesh Prasad; Sujayraj; Sharath Chandra; Chaluvaiah, Kumara; Nair, Ramya; Sandya Kumari; Kalthur, Guruprasad; Adiga, Satish Kumar; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 194 – 199;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-(4-Iodophenoxy)acetic acid

Example 3; A. Podophyllotoxin-4-O-ester of 4-iodophenoxyacetic acid (000614); The mixture of podophyllotoxin (41 mg, 0.1 mmol), 4-iodophenoxyacetic acid (55 mg, 0.2 mmol), EDCI (40 mg, 0.14 mmol), DMAP (2 mg, 0.02 mmol) and dichloromethane (5 ml) were stirred in the room temperature for 20 h, then dichloromethane (20 ml) was added to the solution. Organic layer was washed with water (20 ml), saturated NaHCO3 aqueous solution (10 ml) and brine (20 ml), and then dried over MgSO4. After the solvent was removed under reduced pressure, the resulting liquid was separated by column chromatography (eluent: ethyl acetate and petroleum ether) to afford 35 mg podophyllotoxin-4-O-4-iodophenoxyacetate, mp. The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz); delta 7.60 (t, 2H, Ar-H), 6.69 (d, 2H, Ar-H), 6.61 (s, 1H, Ar-H), 6.53 (s, 1H, Ar-H), 6.36 (s, 2H, Ar-H), 5.98 (d, 3H, OCH2O), 4.74 (q, 2H, COCH2O), 4.60 (d, 1H, H4), 4.34 (t, 1H, H11), 4.20 (t, 1H, H11), 3.81 (s, 3H, OCH3), 3.74 (s, 6H, OCH3), 2.91 (d, 1H, H2), 2.85 (m, 1H, H3).

The synthetic route of 1878-94-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yang, Li-Xi; US2005/4169; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1878-94-0, SDS of cas: 1878-94-0

To (4-iodo-phenoxy)acetic acid (83.5 mg, 0.3 mmol), 3-amino-benzamide (61.3 mg, 0.45 mmol), N-(3-dimethylaminopropyl)-N’-ethyl carbodiimide HCl (EDC) (86.3 mg, 0.45 mmol) and 1-hydroxybenzotriazole (HOBt) (61.3 mg, 0.45 mmol) in DMF (3 ml) was added N,N-diisopropylethylamine, redistilled (DIPEA) (0.08 ml, 0.45 mmol). The mire was stirred overnight, and then partitioned between ethyl acetate and water. The organic phase was washed with brine, dried (MgSO4 anh), and concentrated. The residue was purified by silica gel flash column chromatography (CH2CH2:MeOH=6:1) to give 3-[2-(4-iodo-phenoxy)acetyl-amino]-benzamide as a white solid (105.1 mg, 88.4% yield). 1H-NMR (DMSO-d6) 10.22 (1H, s, NH), 8.09 (1H, s, aromatic-H), 7.94 (1H, s, NH2), 7.79 (1H, d, J=8.1 Hz, aromatic-H), 7.56-7.64 (3H, m, aromatic-H), 7.35-7.41 (2H, m, aromatic-H, NH2), 6.86 (2H, d, J=, 8.7 Hz, aromatic-H), 4.71 (2H, s, CH2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; US2009/306078; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-(4-Iodophenoxy)acetic acid

The mixture of camptothecin (30 mg, 0.086 mmol), 4-iodophenoxyacetic acid (36 mg, 0.18 mmol), EDCI (60 mg, 0.31 mmol), DMAP (5 mg, 0.047 mmol) and dichloromethane (5 ml) was stirred in the room temperature for 20 h, then dichloromethane (20 ml) was added to the solution. Organic layer was washed with water (20 ml), saturated NaHCO3 aqueous solution (10 ml) and brine (20 ml), and then dried over MgSO4. After the solvent was removed under reduced pressure, the resulting solid was separated by column chromatography (eluent: CHCl3:CH3OH 9:1) to afford 46 mg camptothecin-20-O-4-fluorophenoxyacetate, yield: 88.0%, mp 228-230 C. The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz): delta 8.41 (s, 1H, Ar-H), 8.29 (d, 1H, Ar-H), 7.98 (d, 1H, Ar-H), 7.88 (t, 1H, Ar-H), 7.70 (t, 1H, Ar-H), 7.56 (s, 2H, Ar-H), 7.22 (s, 1H, Ar-H), 6.71 (m, 2H, Ar-H), 5.68 (d, 1H, H17), 5.40 (d, 1H, H17), 5.29 (s, 2H, H5), 4.82 (q, 2H, OCH2CO), 2.25 (d, 2H, CH2), 0.97 (t, 3H, CH3).

According to the analysis of related databases, 1878-94-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; California Pacific Medical Center; US6350756; (2002); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 1878-94-0,Some common heterocyclic compound, 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, molecular formula is C8H7IO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation Example 10 Synthesis of Compound 10 (0209) (0210) A vial was charged with a carboxylic acid (371 mg, 1 equiv.), a solvent (1 mL of a solution of 200 g N-oxybenzotriazole in 1 L of DMF), and an amine (254 mg, 1 equiv.). To the stirred reaction mixture, EDC was added (228 mg, 1.1 equiv.). In case the reaction mixture became highly viscous, some more DMF was added. In case the reaction mixture was a homogeneous solution, it was kept at room temperature for 72 hrs. Otherwise, the reaction mixture was sonicated at room temperature for 5 days. The reaction mixture was diluted with 1% aqueous sodium phosphate solution until the vial was full. Then the vial was sonicated. In case a crystalline precipitate was formed, the vial was subjected to the filtration. In case an oily product was formed, the product was dissolved in methanol and precipitated by an addition of 4% hydrochloric acid. Alternatively 2-propanol (1 mL) was mixed with the crude product and the mixture was sonicated. Then the solution was diluted with 5% aqueous sodium hydrogen carbonate solution (the procedure repeated 2-3 times if necessary). The crude product was purified by chromatography (silica gel, chloroform: 2-propanol=4:1) The yield was 506 mg (84%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Iodophenoxy)acetic acid, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF TOKYO; RIKEN; KADOWAKI, Takashi; YAMAUCHI, Toshimasa; IWABU, Miki; IWABU, Masato; YOKOYAMA, Shigeyuki; HONMA, Teruki; (158 pag.)US2016/214967; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, A new synthetic method of this compound is introduced below., COA of Formula: C8H7IO3

A mixture of 5 (846 mg, 3.0 mmol), 11 (869 mg, 5.2 mmol), EDCI (997 mg, 5.2 mmol), HOBt (796 mg, 5.2 mmol), DIPEA (0.89 mL, 5.2 mmol) was dissolved DMF (5 mL) and stirred at room temperature overnight. The reaction was quenched by 1 N of HCl solution and the reaction mixture was extracted with ethyl acetate, neutralized with saturated aqueous NaHCO3 solution, washed with saturated aqueous NaCl solution, dried over anhydrous Na2SO4, and concentrated. The resulting solid was washed with cold methanol to afford 6 (939 g, 2.2 mmol, 73%) as a white solid. This solid compound was pure enough to perform the next step: 1H NMR (400 MHz; CDCl3): delta 9.50 (s, 1H), 8.53 (s, 1H), 7.85 (d, J = 8.2 Hz, 1H), 7.78 (s, 1H), 7.67 (d, J = 8.4 Hz, 2H), 7.07 (d, J = 8.2 Hz, 1H), 6.80 (d, J = 8.4 Hz, 2H), 4.67 (s, 2H), 3.90 (s, 3H); 13C NMR (100 MHz; DMSO) delta 166.5, 166.2, 157.7, 152.0, 138.3, 126.8, 125.7, 122.3, 120.5, 117.7, 114.9, 84.4, 67.2, 52.0; MS (ESI) m/z 428 [M + H]+, 450 [M + Na]+, 466 [M + K]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Nakamura, Hiroyuki; Yasui, Yuka; Ban, Hyun Seung; Journal of Organometallic Chemistry; vol. 747; (2013); p. 189 – 194;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical industry reduces the impact on the environment during synthesis 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, I believe this compound will play a more active role in future production and life. 1878-94-0

General procedure: Synthetic methods of compounds L1-8 were similar with eachother, we took the synthetic method of the compound L1 for example.A mixture of obtained compound 2 (2 mmol, 0.61 g), phenoxyaceticacid (6 mmol, 0.91 g) and phosphorus oxychloride (15 mL)were added to a 25 mL single-necked flask, then the reaction mixturewas heated to 106 C and refluxed for 7 h. The solvent wasremoved under vacuum distillation and cooled at room temperature.Then the residue was poured into ice-water mixture(400 mL) under stirring. The pH value of the mixture was adjustedto 7-8 with diluted NaOH solution. Then the precipitated solid wasseparated by suction filtration, and washed with water to be neutral.The crude product was dried and added to anhydrous ethanol(100 mL), heated to boiling and separated by suction filtration,purified by washing thoroughly with anhydrous ethanol and driedin vacuum to give the title product L1.

The chemical industry reduces the impact on the environment during synthesis 1878-94-0. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yan, Dong; Xiang, Yu; Li, Kangyun; Chen, Yanwen; Yang, Zehui; Guo, Dongcai; Journal of Molecular Structure; vol. 1074; (2014); p. 487 – 495;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1878-94-0

Step 3: N-(3-Fluoro-4-methanesulfonylamino-benzyl)-2-(4-iodo- phenoxy)-acetamide; 3-Fluoro-4-methanesulfonylamino-benzylamine HCI salt (120 mg, 0.471 mmol), NMP (0.25 ml), and (4-iodo-phenoxy)-acetic acid (121 mg, 0.435 mmol) were added in THF (50 ml). After the mixture was stirred for 10 min, DMTMM (138 mg, 0.500 mmol) was added into the mixture. The reaction mixture was stirred overnight. The reaction solvent was removed in vacuo. The resulting residue was extracted with ethyl acetate (60 ml) and H2O (30 ml). The organic layer was washed with saturated K2CO3 (30 ml), 5% HCI solution (30 ml) and brine (30 ml). The organic layer was dried with MgSO4 and concentrated in vacuo. The residue was purified with column chromatography to yield the title compound (172 mg, 83%) as a white solid.Mp: 172 – 153 0C; 1H NMR (300 MHz, CDCI3): delta 7.60 (d, 2H), 7.53 (m, 1H), 7.08 (d, 2H), 6.89 (br, 1H), 6.69 (m, 1 H), 6.45 (br, 1 H), 4.52 (m, 2H), 4.50 (s, 2H), 3.02 (s, 3H)IR (neat, cm’1): 1674, 1650, 1523, 1482, 1330, 1152. MS : 478 (M)

Statistics shows that 1878-94-0 is playing an increasingly important role. we look forward to future research findings about 2-(4-Iodophenoxy)acetic acid.

Reference:
Patent; AMOREPACIFIC CORPORATION; WO2007/120012; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A common heterocyclic compound, 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, molecular formula is C8H7IO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1878-94-0.

The reaction mixture of N-deacetylthiocolchicine (24 mg, 0.064 mmol), 4-iodophenoxyacetic acid (41 mg, 0.15 mmol), EDCI (29 mg), DMAP (2 mg, 0.2 mmol) and dichloromethane (3 ml) was stirred at room temperature for 20 h. Then dichloromethane (20 ml) was added. Organic layer was washed with H2O, 5% Na2CO3 and brine, and then dried over MgSO4. After the solvent was removed under vacuum, the residue was separated by column chromatography (eluent: ethyl acetate and petroleum ether) to afford 35 mg N-Deacetyl-N-(4-iodophenoxyacetyl)thiocolchicine. [0571] The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz).

The synthetic route of 2-(4-Iodophenoxy)acetic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yang, Li-Xi; US2004/204370; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com