Category: 1878-69-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-(3-Iodophenyl)acetic acid

Add 1,1-carbonyldimidazole (0.72 g, 4.40 mmol) to a solution of 3-iodo-phenylacetic acid (1.20 g, 4.6 mmol) in 40 mL of N,N-dimethylacetamide, followed by N,N-diisopropylethylamine (0.79 mL, 4.40 mmol). Stir the mixture at room temperature for 2 h, add 4-cyano-benzoic acid hydrazide (0.64 g (4.0 mmol) and heat the mixture to 60 C for 2 h. Cool the mixture to room temperature and dilute with H20 causing a solid to precipitate from solution. Collect the precipitate by filtration, wash with H20 and diethyl ether dry. Collect any further material that may crystallize from the filtrate. Extract the filtrate with CH2C12 and concentrate the combined organic phase provide a clear liquid. Dilute this mixture with H20 resulting in a third crop of material to precipitate from solution. Collect and combine all solid material to give 1.31 g, 71% yield of 4-cyano-benzoic acid iV-[2-(3-iodo-phenyl)-acetyl]-hydrazide as a powder.

According to the analysis of related databases, 1878-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KIRRANE, JR., Thomas Martin; MARSHALL, Daniel Richard; SIBLEY, Robert; SNOW, Roger John; SOLEYMANZADEH, Fariba; SORCEK, Ronald John; WO2012/54367; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1878-69-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1878-69-9 as follows.

Scheme 12; 156 tert-Butyl 3-(7-(4-Amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenethyl(2- methoxyethyl)carbamate (156); Step 1 : 2-(3-Iodophenyl)-N-(2-methoxyethyl)acetamide (151); To a solution of 3 iodophenylacetic acid (1.12 g, 4.3 mmol) in dichloromethane (50 mL) was added oxalyl chloride (0.75 mL, 8.6 mmol) and DMF (0.05 mL). The mixture was stirred for 1 h at room temperature and concentrated. The residue was dissolved in dry THF (40 mL) and 2-methoxyethylamine (2.0 mL, 23 mmol) was added. The mixture was stirred for 2 h and concentrated. The residue was partitioned between water and ethyl acetate, the organic phase was collected, washed with IM HCl, water, saturated NaHCO3, brine, dried (MgSO4), filtered and concentrated to afford pure 151 (1.23 g, 89 %). 1H NMR (400 MHz, CDCl3) delta (ppm): 7.64- 7.61 (m, 2H), 7.26-7.24 (m, 1H), 7.10-7.06 (m, 1H), 5.81 (br s, 1H), 3.49 (s, 2H), 3.44-3.40 (m, 4H), 3.32 (s, 1H). MS (m/z): 320.1 (M+H).

According to the analysis of related databases, 1878-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; METHYLGENE INC.; WO2009/26717; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-(3-Iodophenyl)acetic acid

Add 1,1-carbonyldimidazole (0.72 g, 4.40 mmol) to a solution of 3-iodo-phenylacetic acid (1.20 g, 4.6 mmol) in 40 mL of N,N-dimethylacetamide, followed by N,N-diisopropylethylamine (0.79 mL, 4.40 mmol). Stir the mixture at room temperature for 2 h, add 4-cyano-benzoic acid hydrazide (0.64 g (4.0 mmol) and heat the mixture to 60 C for 2 h. Cool the mixture to room temperature and dilute with H20 causing a solid to precipitate from solution. Collect the precipitate by filtration, wash with H20 and diethyl ether dry. Collect any further material that may crystallize from the filtrate. Extract the filtrate with CH2C12 and concentrate the combined organic phase provide a clear liquid. Dilute this mixture with H20 resulting in a third crop of material to precipitate from solution. Collect and combine all solid material to give 1.31 g, 71% yield of 4-cyano-benzoic acid iV-[2-(3-iodo-phenyl)-acetyl]-hydrazide as a powder.

According to the analysis of related databases, 1878-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KIRRANE, JR., Thomas Martin; MARSHALL, Daniel Richard; SIBLEY, Robert; SNOW, Roger John; SOLEYMANZADEH, Fariba; SORCEK, Ronald John; WO2012/54367; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 1878-69-9,Some common heterocyclic compound, 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 125 mL round-bottom flask in a 0 C ice bath was added 3-iodobenoic acid (5.0 g, 23 mmol), EDCI (5.0 g, 26 mmol), DCM (50 mL) and allowed to stir for 10 min. To the stirred solution was added DMAP (0.3 mg, 2.3 mmol) and methanol (1.1 mL) and the reaction allowed to stir overnight. Disappearance of SM was monitored by HPLC. Reaction mixture was diluted with DCM, washed with 1 N HCI, dried with magnesium sulfate, and concentrated in vacuo. Required column chromatography (10: 1 Hex/EtOAc) to isolate product (4.56 g, 87%); LC rt = 3.77 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(3-Iodophenyl)acetic acid, its application will become more common.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/70407; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1878-69-9,Some common heterocyclic compound, 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

lll.delta.a 2-(3-iodophenyl)ethanol A solution of 9.3 g (33.7 mmol) (3-iodophenyl)acetic acid is dissolved in 160 ml dry THF and cooled to 00C. Then 34,0 ml of a 1 ,0 M solution of lithium aluminumhydride in THF (34,0 mmol) is slowly added. The reaction mixture is allowed to warm to room temperature and stirred for 2 hours. The excess lithium aluminumhydride is carefully destroyed with a few drops of water and the resulting mixture is filtered through celite. The solvent is removed in vacuo leaving the crude product, which is used without further purification in the next step. Yield: 6.83 g (81% of theory), C8H9IO EII mass spectrum: m/z = 249 [M+H]+

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H7IO2

To a solution of 3-iodorhohenylacetic acid (24.8 g, 94.6 mmol) in CH2Cl2 (200 mL) was added oxalyl chloride (189 mmol, 2 equiv), followed by a drop of DMF. The mixture was stirred at room temperature for Ih and then concentrated. Addition of ethanol and purification by flash chromatography (EtOAc/Hex) gave yellow oil as product. 1H NMR (600 MHz, CDCl3): delta = 7.63 (s, 1 H), 7.59 (d, 1 H), 7.25 (d, 1 H), 7.04 (t, 1 H), 4.16 (q, 2 H), 3.53 (s, 2 H), 1.25 (t, 3 H); LRMS: m+1 (291.0, 4.228 min.).

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1878-69-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows.

200 mg (0.73 mmol) of (3-iodophenyl)acetic acid were dissolved in 4 mL of N,N dimethylacetamide and 244 mg (0.76 mmol) of TBTU, followed by 150 mu (o.80 mmol) of N-diisopropyl-N’-ethyl amine and 177 mg (1.1 mmol) of 3- (trifluoromethyl)aniline were added. The mixture was maintained at room temperature for 2 hours, then diluted withethylacetate, washed with aqueous NaHC03, HQ 2N, water and brine. The crude was triturated with a mixture diisopropyl ether-hexane affording, after filteration, 200 mg of the title compound as a white solid (68%). 1H NMR (401 MHz, DMSO-de) delta ppm 7.14 (t, J=7.75 Hz, 1 H) 7.35 (d, J=7.69 Hz, 1 H) 7.40 (d, J=7.81 Hz, 1 H) 7.55 (t, J=7.99 Hz, 1 H) 7.63 (dt, J=7.84, 1.39 Hz, 1 H) 7.73 (t, J=1.59 Hz, 1 H) 7.77 (d, J=8.30 Hz, 1 H) 8.08 (s, 1 H) 10.50 (s, 1 H)

The chemical industry reduces the impact on the environment during synthesis 2-(3-Iodophenyl)acetic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; ANGIOLINI, Mauro; BUFFA, Laura; MENICHINCHERI, Maria; MOTTO, Ilaria; POLUCCI, Paolo; TRAQUANDI, Gabriella; ZUCCOTTO, Fabio; WO2014/184069; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H7IO2

EXAMPLE A.4. Compound c-3 (127l): 4-(4-fluoro-3-(4-(2-(3-iodophenyl)acetyl)piperazine-l-carbonyl)- benzyl)phthalazin-l(2H)-one. A solution of 3-iodophenyl acetic acid (6.5 mg, 0.048 mmol), l-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) (10.5 mg, 0.055 mmol), N-hydroxy succinimide (NHS) and 600 mu DM F was stirred for 30 min at room temperature. Then, 4-(4-fluoro-3-(piperazine-l-carbonyl)benzyl)- phthalazin-l(2H)-one (10 mg, 0.0275 mmol) was added to the solution and the mixture was stirred at room temperature overnight. The reaction was washed with 500 mu of H20 and extracted with 500 mu dichloromethane (DCM). The resulting organic solution was purified on silica gel, using a gradient elution from neat DCM to DCM/hexane 5:1 to obtain the desired product as a white solid (3 mg, 20% yield). 1H NMR (CDCI3) delta = 9,82 (s, 1H), 8.40-8.38 (m, 1H), 7.71-7.69 (m, 2H), 7.55-7.53 (m, 1H), 7.51-7.50 (m, 2H), 7.25-7.24 (m, 2H), 7.09-6.90 (m, 3H), 4.20 (s, 2H), 3.64-3.31 (m, 8H), 2.84 (s, 2H). LC-ESI-MS (+) m/z = 633.1 [M+Na+]+. HRMS-ESI [M+H+]+ m/z calculated for [C28H24FIN403]+ 611.0955, found 611.0948.

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEMORIAL SLOAN KETTERING CANCER CENTER; REINER, Thomas; LEWIS, Jason S.; WEBER, Wolfgang; RODRIGUEZ, Beatriz Salinas; CARNEY, Brandon; CARLUCCI, Giuseppe; (89 pag.)WO2016/33293; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1878-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1878-69-9, name is 2-(3-Iodophenyl)acetic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of 9 (60 mg, 0.34 mmol) in DMF (3 mL) HOBt (60 mg, 0.35 mmol) and EDC (68 mg, 0.35 mmol) were added at 0 C. The mixture was stirred at 0 C for 15 min and at room temperature for 1 h. Then, 4-tert-butylaniline (64 L, 0.40 mmol) was added, and the mixture was stirred at room temperature overnight. The mixture was diluted with brine and extracted with AcOEt. The organic phase was washed with 2 N HCl solution, saturated NaHCO3, and brine, dried (NaSO4), and evaporated under vacuum. The residue (105 mg) was chromatographed on silica gel (6 g) using petroleum ether/AcOEt = 93/7 as eluent to give 80 mg (77%) of 4a.

The synthetic route of 2-(3-Iodophenyl)acetic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ortar, Giorgio; Morera, Ludovica; Schiano Moriello, Aniello; Morera, Enrico; Nalli, Marianna; Di Marzo, Vincenzo; De Petrocellis, Luciano; Bioorganic and Medicinal Chemistry Letters; vol. 22; 10; (2012); p. 3535 – 3539;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1878-69-9, Adding a certain compound to certain chemical reactions, such as: 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1878-69-9.

To a suspension of 2-(2-Amino-5-ethynyl-pyrimidin-4-yl)-1-methyl-4-oxo-1 ,4,6,7 -tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (1.56 g, 4.25 mmol) in degassed MeCN (25 ml), Cui (1 0% mol, 81 mg, 0.425 mmol),3-iodophenylacetic acid (1.17 g, 4.25 mmol), TEA (5.92 ml, 42.48 mmol) and PdCb(PPh3)2 (1 0% mol, 0.30 g, 0.425mmol) were added. The mixture was degassed for three times back filling with argon each time and let under stirring5 at r.t. for 1 h. The reaction was quenched with 2 N HCI (21.2 ml) and the solvent was removed under reducedpressure. The residue was suspended in water and the resulting solid was filtered and rinsed with water affording thetitle product and brownish solid (1.62 g, 76%).(ESI) m/z 502 [(M +H)+]. HRMS (ESI) calculated for C21H2sN505 [(M + H)+]502.2085; found 502.2074.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Iodophenyl)acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; MENICHINCHERI, Maria; ANGIOLINI, Mauro; BERTRAND, Jay Aaron; CARUSO, Michele; POLUCCI, Paolo; QUARTIERI, Francesca; SALOM, Barbara; SALSA, Matteo; ZUCCOTTO, Fabio; WO2014/72220; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com