Category: 18698-96-9

Reference of 18698-96-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows.

Example 93: 2-Methyl-N-(2-phenylethyl)-10,11-dihydrodibenzo[b,f]thiepine-3- sulfonamide 5,5- dioxide.Step 1. {2-[(4-Methylphenyl)thio]phenyl}acetic acidCO2H[0338] A mixture of 4-methyl benzene thiol (12.85 g, 104 mmol), 2-iodo-phenyl acetic acid (24.7 g, 94.2 mmol), copper powder (1.01 g) and potassium hydroxide (26.1 g, 471 mmol) in water (600 ml_) was heated to reflux overnight. The reaction filtered to remove the copper salts and made acidic with concentrated HCI and diluted with water. The aqueous layer (1 L) was filtered to afford the desired product as a solid that was triturated with methanol to afford 13.36 g of white solid (55 %).[0339] MS (ESI) m/z 257;HRMS: calculated for Ci5Hi4O2S + H+, 259.07873; found (ESI, [M+Hf), 259.0786

The chemical industry reduces the impact on the environment during synthesis 2-(2-Iodophenyl)acetic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; WYETH; WO2008/61029; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 18698-96-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows.

Key Intermediate 1: 2-(2-Ethynylphenyl)butanamide (KI)(a) 2-(2-Iodophenyl)butanoic acid (Ii)Lithium diisopropylamide solution (2.0 M in THF/heptane/ethylbenzene, 3.82 mL, 7.63 mmol) was added to dry THF (10 mL) under an atmosphere of nitrogen and cooled to 0 00. A solution of 2-(2-iodophenyl)acetic acid (500 mg, 1.91 mmol) in dryTHF (15 mL) was then added dropwise. This solution was stirred for 40 minutes at 000 before the addition of iodoethane (0.92 mL, 11 mmol). The solution was returnedto room temperature and stirred for 4 hours. The resulting mixture was quenched with the addition of H20 (10 mL) and then 2 M HCI (20 mL). The aqueous layer was extracted with EtOAc (3 x 30 mL), the organic layers were combined and washedwith brine, dried over Mg504 and the solvent was evaporated under reducedpressure. The residue was adsorbed onto silica gel and purified using columnchromatography (Biotage Isolera, 5i02 cartridge, 0-40percent EtOAc in petroleum benzine40-60 00) to give the title compound Ii as a pale yellow oil (479 mg, 87percent); 1H NMR(400 MHz, d6-DMSO) O 12.49 (5, 1H), 7.88 (dd, J= 7.9, 1.2 Hz, 1H), 7.39 (td, J= 7.6,1.2 Hz, 1H), 7.32 (dd, J= 7.8, 1.7 Hz, 1H), 7.01 (Jm, 1H), 3.77 (t, J= 7.5 Hz, 1H),1.98?1.86 (m, 1H), 1.73?1.60 (m, 1H), 0.85 (t, J= 7.3 Hz, 3H).JH2Ii 12 13 Ki

The chemical industry reduces the impact on the environment during synthesis 2-(2-Iodophenyl)acetic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter; WO2014/26243; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18698-96-9 as follows. Computed Properties of C8H7IO2

A suspension of 2-iodophenyl acetic acid (1 g, 3.82 mmol), 4-bromobenzenethiol (0.722 g, 3.82 mmol), KOH (0.427 g, 7.63 mmol) and copper powder (24 mg, 0.38 mmol) in 2 mL of water, was allowed to react in microwave (conditions: 2.x.6 min, 180 W, T max=100¡ã C., P max=100 psi). The suspension obtained was dissolved in 2N aqueous solution of KOH and then filtered. The filtrate was acidified with 1N aq. HCl; the white precipitate was filtered, dried in vacuo, purified by trituration with acetone to give the pure acid 1-bis as white solid (1.16 g, 94percent).1H-NMR (CDCl3, 200 MHz): 7.44 (d, J=7 Hz, 1H); 7.36-7.26 (m, 5H); 7.01 (d, J=8.4 Hz, 2H); 3.86 (s, 2H).Anal. Calcd. for C14H11BrO2S (MW=323.2): C, 52.03; H, 3.43; Br, 24.72; O, 9.90; S, 9.92.

According to the analysis of related databases, 18698-96-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRACCO IMAGING SPA; US2009/239829; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 18698-96-9

General procedure: Pd(OAc)2 (22.4 mg, 0.10 mmol, 0.1 equiv), Ph3P (57.6 mg, 0.22, 0.22 equiv), and Cs2CO3 (1.63 g, 5 mmol, 5 equiv) were added to a flamedried, sealable vial under argon. Dry, degassed MeCN or DMF (3 mL) was added and the yellow mixture was stirred under argon for approximately 5 min. Aryl iodide (1.00 mmol, 1 equiv), alkyl iodide (10.00 mmol, 10 equiv), and olefin (5.00 mmol, 5 equiv) were added successively to the reaction mixture under argon. The mixture was stirred for 5 min, then solid norbornene (470 mg, 5.00 mmol, 5 equiv) was added. After a final argon purge, the vial was capped and placed in an oil bath that had been preheated to 90 ¡ãC. After 4?10 h, the mixture was cooled to r.t. Reactions performed in MeCN were filtered over a short pad of Celite (eluting with CH2Cl2) and concentrated in vacuo. Reactions performed in DMF were diluted with EtOAc? hexanes (1:1) and washed with brine twice. After drying with MgSO4, the organic layer was filtered and concentrated. The crude products were purified by flash column chromatography (CH2Cl2?hexanes, 1:5, then Et2O?hexanes, 1:100?1:25).

The synthetic route of 18698-96-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Qureshi, Zafar; Schlundt, Waldemar; Lautens, Mark; Synthesis; vol. 47; 16; (2015); p. 2446 – 2456;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18698-96-9 as follows. 18698-96-9

1 -Hydroxybenzotriazole (2.58 g, 19.1 mmol), EDCI (2.96 g, 19.1 mmol) and diisopropylethylamine (12.1 mL, 69.3 mmol) were added sequentially to a solution of 2-(2- iodophenyl)acetic acid (4.54 g, 17.3 mmol) in DMF (22 mL) and THF (151 mL) under a N2 atmosphere. The reaction mixture was allowed to stir at rt for 10 min. Ammonium carbonate (6.66 g, 69.3 mmol) was then added in one portion to the reaction mixture, which was then left to stir at rt overnight. The mixture was cone, in vacuo and water was added. The mixture was extracted with EtOAc, washed with H20, sat. aq. NaHC03 sol. and brine before drying over MgS04 and cone, in vacuo. The solid was suspended in EtOAc before being collected by vacuum filtration to give the title compound as an off-white solid (2.73 g, 60 percent). LCMS (Method 1 ) Rt 1.859 min.

According to the analysis of related databases, 18698-96-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIONOMICS LIMITED; HARVEY, Andrew John; RIPPER, Justin Anthony; HUFF, Belinda Cheryl; PAUL, Dharam; WO2015/123722; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

18698-96-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, A new synthetic method of this compound is introduced below.

2-lodophenylacetic acid (2.00 g, 7.63 mmol) was dissolved in dry THF (70 mL) and dry DMF (10 mL) under an atmosphere of nitrogen. To the solution were added 1 – hydroxybenzotriazole (1.134 g, 8.396 mmol) and EDCI (1 .609 g, 8.396 mmol) and /V,/V-diisopropylethylamine (5.318 mL, 30.53 mmol) and the reaction mixture was stirred at room temperature for 10 minutes. Ammonium carbonate (2.933 g, 30.53 mmol) was added in one portion, and the reaction was stirred room temperature for 7 hours. The volatiles were removed in vacuo and the residual solution was diluted with EtOAc (150 mL) and sat. aq. NaHC03 (100 mL). The layers were separated and the organic layer were washed with water (100 mL), brine (100 mL), dried (MgSO), filtered and concentrated in vacuo to give the title compound (138) (1.755 g, 88percent yield) as a beige solid; 1H NMR (400 MHz, cfe-DMSO) delta 7.82 (dd, J = 7.9, 0.9 Hz, 1 H), 7.42 (s, 1 H), 7.36 – 7.28 (m, 2H), 7.02 – 6.94 (m, 2H), 3.55 (s, 2H). LCMS Method C: Pi 4.77 min; m/z 262.0 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; HOLMES, Ian, Peter; BERGMAN, Ylva; LUNNISS, Gillian Elizabeth; NIKAC, Marica; CHOI, Neil; HEMLEY, Catherine Fae; WALKER, Scott Raymond; FOITZIK, Richard Charles; GANAME, Danny; LESSENE, Romina; WO2012/110773; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

18698-96-9, A common compound: 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Aminoester 76 (0.92 g, 4.50 mmol) and 2-(2-iodophenyl)acetic acid (1.36 g, 5.2 mmol) were dissolved in 23 ml butyl acetate. 1-Propanephosphonic anhydride solution (T3P, 7 ml, 11.7 mmol) was added and the mixture was stirred for 1 h at room termpature and then 1 h at reflux. The mixture was allowed to cool to room temperature and was washed twice with 4percent sodium bicarbonate solution. The organics were dried over anhydrous sodium sulphate, filtrered and evaporated under reduced pressure. The residue was purified using the SP-1 purification system (ethyl acetate-hexane gradient, 0:100 rising to 30:70) to give 77 (1.1 g, 2.62 mmol, 58percent yield) as a pale yellow solid. Purity 100percent. 1H NMR spectrum not recorded. UPLC/MS (3 min) retention time 1.76 min. LRMS: m/z 421 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 102 – 133;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18698-96-9 as follows. 18698-96-9

STR164 Step 1–Preparation of 2-(2-Iodophenyl)ethanol. A solution of o-iodophenylacetic acid (19.87 g, 75.83 mmol) in dry tetrahydrofuran (110 mL) was added dropwise over 41 min to a solution of borane in tetrahydrofuran (151 mL of 1 M solution, ca. 151.0 mmol) which was cooled with an ice-water bath. The reaction was stirred at 0 to 10 C. for 2 hr 15 min. After the reaction mixture was cooled to 0 C., it was quenched by cautious addition (frothing|) of 10 (vol.) % acetic acid in methanol over 20 min. Stirring was continued for 25 min before the reaction was concentrated on a rotary evaporator. The residue was dissolved in ethyl acetate and washed with saturated ammonium chloride followed by saturated sodium bicarbonate. The organics were dried (Na2 SO4) and concentrated to a yellow oil (18.07 g) which was used in the next step without purification. TLC (hexane-ethyl acetate, 1:1): Rf =0.71; 1 H-NMR (DMSO-d6): delta 2.81 (t, J=7.2 Hz, 2H), 3.53 (dt, J=5.1 Hz, 7.5 Hz, 2H), 4.73 (t, J=5.4 Hz, 1H), 6.90-6.95 (m, 1H), 7.29 (dd, J=4.9 Hz, 0.8 Hz, 2H), 7.79 (d, J=7.7 Hz, 1H); MS (EI) 248 [M]+ (C8 H9 IO, FW=248.07).

According to the analysis of related databases, 18698-96-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Corporation; US5886022; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 18698-96-9

(1-bis) A suspension of 2-iodophenyl acetic acid (Ig, 3.82 mmol), 4-bromobenzenethiol (0.722 g, 3.82 mmol), KOH (0.427 g, 7.63 mmol) and copper powder (24 mg, 0.38 mmol) in 2 mL of water, was allowed to react in microwave(conditions: 2x 6 min, 180 W, T max=100¡ãC, P max=100 psi) .The suspension obtained was dissolved in 2N aqueous solution of KOH and then filtered. The filtrate was acidified with IN aq. HCl; the white precipitate was filtered, dried in vacuo, purified by trituration with acetone to give the pure acid 1-bis as white solid (l.ldeltag, 94percent) .1H-NMR (CDCl3, 200MHz): 7.44 (d, J= 7Hz, IH); 7.36-7.26 (m, 5H); 7.01 (d, J= 8.4Hz, 2H); 3.86 (s, 2H). Anal. Calcd. for Ci4H11BrO2S (MW=323.2): C 52.03; H 3.43; Br 24.72; O 9.90; S 9.92.; Example 62- (2-biphenyl-4-ylthio) phenyl) acetic acid (19a), 2- (2- (4- methoxyphenylthio) phenyl) acetic acid (19b), 2- (2-biphenyl-4- ylthio) phenyl) -N-hydroxyacetamide (21a), N-hydroxy-2- (2- (4- methoxyphenylthio) phenyl) acetamide (21b) and 2- (2- (4- (but-2- iniloxy) phenylthio) phenyl) -N-hydroxyacetamide (21c); (16) Compound 16 was synthesized according to the procedure described for the preparation of 10, starting from o-iodophenylacetic acid (5 g, 19.08 mmol) and 4- bromobenzenethiol (2.4 g, 19.08 mmol) into 5 portions of 1 g each. The obtained suspension was collected and diluted in KOH 2N. The obtained suspension was filtered and acidified with HCl IN. The formed precipitate was brought to dryness under reduced pressure at 500C. There were recovered 4.37 g of 16 (88percent, white solid) . 1H-NMR (de-DMSO, 200MHz ) : 3 . 74 ( s , 2H) , 7 . 07 (d, J=8Hz , 2H) , 7 . 30 -7 . 42 (m, 4H) 7 . 4 9 (d, J=8Hz , 2H) , 12 . 34 (br . s , IH) .

Statistics shows that 18698-96-9 is playing an increasingly important role. we look forward to future research findings about 2-(2-Iodophenyl)acetic acid.

Reference:
Patent; BRACCO IMAGING SPA; UNIVERSITA DI PISA; WO2008/15139; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com