Category: 181765-86-6

Synthetic Route of 181765-86-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

2- bromo -4- chloro- 1- iodobenzene (87.5 g), 1- naphthylboronate (100 g), the tetrahydrofuran (1 L), the potassium carbonate (200.9 g) and water (720 mL) were put in 5 L three holes round bottom flask and it was stirred. The tetrakis (triphenylphosphine) palladium (0) (13.4 g) was put into the mixed solution and 80 heated for 24 hours. The reaction solution was cooled in a room temperature and it extracted in the dichloromethane. After it was dry to the magnesium sulfate it was the organic layer concentrated under reduced pressure and the solvent was removed. Material generated with the concentration were washed with the methanol and the powder I-2 of gray was obtained with 72 g.

The chemical industry reduces the impact on the environment during synthesis Methyl 5-bromo-2-iodobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Daejoo Electronic Materials Co., Ltd.; Kim, Hyung Ho; Jeon, Young Min; Nam, Sang Jin; Kim, Soo Hyun; Kim, Min Young; Kim, Jun Woo; (29 pag.)KR2016/113488; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 181765-86-6, These common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 5-bromo-2-iodobenzoic acid (25.0 g, 73 mmol) was charged in a 500 mL round bottom flask reactor,4-dibenzofuran boronic acid (18.7 g, 88 mmol), tetrakis (triphenylphosphine) palladium (1.7 g, 0.15 mmol), potassium carbonate (20.2 g, 146.7 mmol)And 125 mL of toluene, 125 mL of tetrahydrofuran, 50 mL of water. The temperature of the reactor was raised to 80 C and stirred for 10 hours.After completion of the reaction, the temperature of the reactor was lowered to room temperature, and the organic layer was extracted with ethyl acetate and separated.The organic layer was concentrated under reduced pressure and then separated by column chromatography to obtain (75.0 g, 60.1%).

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC Co., Ltd.; Che Chunxu; Po Xipei; Po Shangyu; Shen Youna; Jin Xida; (130 pag.)CN107207454; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 181765-86-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried Schlenk tube equipped with a Teflon valve was charged with a magnetic stir bar, CuI (10 mg, 0.05 mmol, 10 mol%), K2CO3 (276 mg, 2.0 mmol), 1,10-phenanthroline (20 mg, 0.10 mmol, 20 mol%) and cyclic thiourea (0.5 mmol), 4 ? Molecular Sieves. The tube was evacuated and backfilled with N2 (this procedure was repeated 3 times). Under a counter flow of N2, methyl-2-iodobenzoate 1 (0.6 mmol) and DMF (2.0 mL) were added by syringe. The mixture was stirred at 100 ?C for 24h. After the reaction was completed, the mixture was directly passed through celite and rinsed with 30 mL of EtOAc. The combined filtrate was concentrated and purified by column chromatography on silica gel to give the pure product.Yellow Yellow solid; mp 152-154 C; 1H NMR (200 MHz, CDCl3) delta 8.31 (d, J = 2.0 Hz, 1H), 7.56 (dd, J1 = 8.6 Hz, J2 = 2.4 Hz, 1H), 7.07 (d, J = 8.6 Hz, 1H), 3.53-3.39 (m, 1H), 3.29-3.15 (m, 1H), 3.07-3.02 (m, 1H), 2.38-2.33 (m, 1H), 1.90-1.86 (m, 2H), 1.74-1.34 (m, 4H); 13C NMR (50 MHz, CDCl3) delta 160.9, 153.8, 136.4, 133.3, 131.1, 126.8, 126.2, 120.6, 71.9, 67.6, 31.0, 30.7, 29.9, 25.4, 24.9 ppm. Anal. Calcd. for C14H13BrN2OS: C 49.86, H 3.89, N 8.31; found: C 50.05, H 4.01, N 8.20; EI-MS: m/z = 336 (M+), 338(M+2).

The chemical industry reduces the impact on the environment during synthesis Methyl 5-bromo-2-iodobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Chen, Dingben; Wu, Jiashou; Yang, Jianguo; Huang, Ling; Xiang, Yubo; Bao, Weiliang; Tetrahedron Letters; vol. 53; 52; (2012); p. 7104 – 7107;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 181765-86-6, The chemical industry reduces the impact on the environment during synthesis 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, I believe this compound will play a more active role in future production and life.

Methyl 5-bromo-2-iodo-benzoate (methyl 5-bromo-2-iodobenzoate) (3.849 g, 11.259 mmol) and compound 23-5 (phenanthren-1-ylboronic acid) (3 g, 13.510 mmol), 2 mol / L potassium carbonate (potassium carbonate) (inH2O, 30 mL), tetrakis (triphenylphosphine) palladium (tetrakis (triphenylphosphine) palladium) (0.651 g, 0.563mmol) in tetrahydrofuran (tetrahydrofuran) and 100 mL of methanol (methanol) 30 mL and mixed under a nitrogen atmosphere it was heated for 24 hours ,after that remove the solvent after confirmation, and the reaction was terminated via TLC celite (celite)Filtered in the following, by using dichloromethane and H2O, the organic layer was separated and washed with, saturated sodium chloride solution and bovineBy filtration using a rhodium sulfate (Sodium sulfate) to remove the moisture. The solvent from the results obtained therefrom(3.5g, 79%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-2-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Samsung Display Co. ltd., Samsung Display Co. ltd.; Seoul National University Industrial-Academic Cooperation Foundation; Kim, Se Hoon; Jung, Seong Jin; Hong, Chong In; Kim, Mi Yeong; Choo, Chang Woong; (72 pag.)KR2016/9768; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 181765-86-6, A common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[Intermediate 1-a] was synthesized according to Scheme 1 below.Methyl 5-bromo-2-iodobenzoate (25.0 g, 73 mmol) in a 500 mL round bottom flask reactorAdd 4-dibenzofuranboronic acid (18.7g, 88mmol), tetrakis (triphenylphosphine) palladium (1.7g, 0.15mmol), potassium carbonate (20.2 g, 146.7mmol), 125mL toluene, 125mL tetrahydrofuran 50 mL of water was added thereto.The temperature of the reactor was raised to 80 degrees and stirred for 10 hours. After the reaction was completed, the temperature of the reactor was lowered to room temperature, extracted with ethyl acetate, and the organic layer was separated.The organic layer was concentrated under reduced pressure and separated by column chromatography to obtain Intermediate 1-a (75.0 g, 60.1%).

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC Ltd.; Cha Sun-uk; Jeong Gyeong-seok; Song Ju-man; Lee Yu-rim; Park Sang-u; Kim Hui-dae; Park Seok-bae; (65 pag.)KR2019/111856; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Methyl 5-bromo-2-iodobenzoate

500ml three-necked round bottom flask was charged with methyl 5-bromo-2-iodo benzoate (130g, 0.381mol), as 9-phenanthrene boronic acid(84.7g, 0.381mol), 2% of tetrakis triphenylphosphine palladium (8.82g, 0.008mol), 2M potassium carbonate (100ml), tetrahydrofuran (200ml) was added. 16 hours with stirring and reflux under reduced pressure and then extracted with ethyl acetate concentrate was purified by silica gel column (ethyl acetate: heptane = 1: 5) to give the [intermediate 1-a] (120g, yield = 80.4%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 181765-86-6.

Reference:
Patent; SFC CO., LTD.; JU MAN, SONG; HEE DAE, KIM; YUR IM, LEE; SANG WOO, PARK; PARK, SEOK BAE, PARK; KYUNG SEOK, JEONG; SOON WOOK, CHA; (36 pag.)KR2015/113642; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, A new synthetic method of this compound is introduced below., name: Methyl 5-bromo-2-iodobenzoate

(a) 5-Bromo-2-(4-nitrobenzoyl)benzoic acid methyl ester; /-PrMgCI LiCI in THF (1.25M.17.6 ml_, 22 mmol) was added to 5-bromo-2-iodo- benzoic acid methyl ester (6.82 g, 20 mmol) in THF (40 ml_) at -40 0C over 5 min. The mixture was stirred at -30 0C for 1 h, cooled to -78 0C and added to 4-nitro- benzoyl chloride (7.42 g, 40 mmol) in THF (30 mL) at -78 0C. The temperature was allowed to reach rt and NaHCO3 (aq, sat) was added. Extractive workup (EtOAc, NaHCO3 (aq, sat), H2O, brine), drying (K2CO3 and Na2SO4), concentration and crystallization from EtOAc gave the sub-title compound. Yield: 5.48 g (75%).

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOLIPOX AB; NILSSON, Peter; PELCMAN, Benjamin; KATKEVICS, Martins; WO2010/103279; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 181765-86-6,Some common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,9 g (14,9 mmol) of (1 , 1′-biphenyl)-2-yl-boronic acid, 4,6 g (13,6 mmol) of methyl 5-bromo-2-iodobenzoate, 314 mg (0,3 mmol, 0,02 eq.) of Pd(P(Ph3))4, 5,6 g (40,7mmol, 3 eq.) of Na2C03 are dissolved in 7 mL of water and 30 mL of toluene. The reaction mixture is stirred at 85C and agitated under an argon atmosphere for 12 hours and after cooling to room temperature, the mixture is filtered through Celite. The filtrate is evaporated in vacuo, and the residue is purified by (0273) chromatography (mixture heptane/AcOEt). The product is isolated in the form of an off-white solid (4,5 g 91 % of theory).

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; MONTENEGRO, Elvira; MUJICA-FERNAUD, Teresa; MAIER-FLAIG, Florian; VOGES, Frank; COMELY, Alexander; MORENO FLORES, Rosa; (201 pag.)WO2019/115577; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 181765-86-6, A common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

500mL round-bottom flask reactor, methyl 5-bromo-2-iodo benzoate (25.0g, 73mmol) in 4-dibenzofuran boronic acid [0410] (18.7g, 88mmol), tetrakis (triphenylphosphine) palladium (1.7g, 0.15mmol), potassium carbonate (20.2 g, 146.7mmol) put the toluene 125 mL, tetrahydrofuran 125mL, water 50 mL. The temperature of the reactor was 80 C, 10 hours was stirred. When the reaction is complete cool down the temperature of the reactor to room temperature, extracted with ethyl acetate and the organic layer was separated It was. The organic layer was concentrated under reduced pressure and separated by column chromatography to give the intermediate 1-a. (75.0g, 60.1%)

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC CO LTD; PARK, SEOK BAE; SONG, JU MAN; LEE, YUR IM; KIM, HEE DAE; PARK, SANG WOO; JEONG, KYUNG SEOK; CHA, SOON WOOK; (96 pag.)KR2015/130206; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 5-bromo-2-iodobenzoate

To a stirred mixture of NaBH4 (11.18 g, 0.296 mol) in EtOH (200 ML) at 5 C. was added the product from Example 62A (50.4 g, 0.148 mol) in THF (100 ML).The mixture was alowed to warm to room temperature and stirred for 18 hours.The mixture was treated with additional NaBH4 (8.4 g, 0.222 mol) and was stirred for 22 hours.The mixture was cooled to 0 C., treated with 100 ML of 15% aqueous citric acid slowly, and extracted with 600 ML of CH2Cl2.The organic phase was washed with 200 ML of 15% NaCl and concentrated to provide the title compound. 1H NMR (CDCl3, 400 MHz) delta 7.64 (d, J=8 Hz, 1H), 7.61 (d, J=4 Hz, 1H), 7.12 (dd, J=4, 8 Hz, 1H), 4.63 (d, J=8 Hz, 2H), 1.98 (t, J=8 Hz, 1H). MS (DCl/NH3) [M+NH4]+ at 330, [M+NH4-H2O]+ at 312.

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.; US2004/92521; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com