Category: 181765-86-6

Related Products of 181765-86-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

500mL round-bottom flask reactor, methyl 5-bromo-2-iodo benzoate (25.0g, 73mmol) in 4-dibenzofuran boronic acid(18.7g, 88mmol), tetrakis (triphenylphosphine) palladium (1.7g, 0.15mmol), potassium carbonate (20.2 g,Put 146.7mmol) were placed 125 mL toluene, tetrahydrofuran, 125mL, water 50 mL. The temperature of the reactor 80 road winsOn and stirred 10 hours. When the reaction is complete cool down the temperature of the reactor to room temperature, extracted with ethyl acetate and the organicAnd separating the base layer. The organic layer was obtained an intermediate a-1 (75.0g, 60.1%) and, after concentration under reduced pressure, separated by column chromatography

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-2-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SFC CO., LTD.; CHA, SUN OK; JONG, KYONG SEOK; SONG, JOO MIN; LEE, YU RIM; PARK, SANG WOO; KIM, HUI DAE; PARK, SEOK BAE; (76 pag.)KR2016/13678; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 181765-86-6, A common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of sodium borohydride (1 .1 g, 14.7 mmol, 2 equiv) in ethanol (20 mL) was added methyl 5-bromo-2-iodobenzoate in THF (10 mL) at 5C. The reaction mixture was warmed to room temperature and stirred for 18 h under nitrogen atmosphere. Additional quantity of sodium borohydride (0.84 g, 22 mmol, 1 .5 equiv) was added and the mixture was stirred for 22 h. The reaction mixture was cooled to 0C, treated with 10 mL of 15% citric acid slowly. The reaction mixture was extracted with DCM (2 x 75 mL). The organic layer was washed with 15% of aq. NaCI (100 mL), and then dried over sodium sulphate and evaporated to obtain (5-bromo-2-iodophenyl)methanol (4.5 g, 100%) as white solid. NMR (400 MHz, CDCI3) delta ppm 1 .83 – 1 .88 (m, 1 H), 4.63 (s, 2H), 7.12 (dd, J=2.8, 8.4 Hz, 1 H), 7.62- 7.66 (m, 2H).

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey; KETHIRI, Raghava Reddy; KRISTAM, Rajendra; VENKATESHAPPA, Chandregowda; (162 pag.)WO2018/15879; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 181765-86-6,Some common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

500mL round-bottom flask reactor, methyl 5-bromo-2-iodo benzoate (25.0g, 73mmol) in 4-dibenzofuran boronic acid (18.7g, 88mmol), tetrakis (triphenylphosphine) palladium (1.7g, 0.15mmol), potassium carbonate (20.2 g, 146.7mmol) put the toluene 125 mL, tetrahydrofuran 125mL, water 50 mL. The temperature of the reactor was 80 C, 10 hours was stirred. When the reaction is complete cool down the temperature of the reactor to room temperature, extracted with ethyl acetate and the organic layer was separated It was. The organic layer was concentrated under reduced pressure and separated by column chromatography to give the intermediate 1-a. (75.0g, 60.1%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-bromo-2-iodobenzoate, its application will become more common.

Reference:
Patent; SFC CO LTD; PARK, SEOK BAE; SONG, JU MAN; LEE, YUR IM; KIM, HEE DAE; PARK, SANG WOO; JEONG, KYUNG SEOK; CHA, SOON WOOK; (96 pag.)KR2015/130206; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H6BrIO2

In a 500-mL round-bottom flask reactor, methyl 5-bromo-2-iodobenzoate (25.0 g, 73 mmol), 4-dibenzofuran boronic acid (18.7 g, 88 mmol), tetrakis (triphenylphosphine)palladium (1.7 g, 0.15 mmol), and potassium carbonate (20.2 g, 146.7 mmol) stirred together with toluene (125 mL), tetrahydrofuran (125 mL), and water (50 mL) for 10 hrs at 80 C. After completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ethyl acetate. The organic layer thus formed was separated, concentrated in a vacuum, and purified by column chromatography to afford . (75.0 g, 60.1%).

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC CO., LTD.; Pyo, Sung-Wan; Shim, So Young; Yu, Se Jin; (133 pag.)US2017/12214; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 5-bromo-2-iodobenzoate

A magnetically stirred and degassed mixture of compound 5 (1.39 g, 20.8 mmol), compound 37 (6.45 g, 18.9 mmol), Cul (359 mg, 1.9 mmol), 1 , 10-phenanthroline (680 mg, 3.8 mmol) and Cs2C03 (9.30 g, 28.4 mmol) in anhydrous toluene (40 mL) was heated at 100 C under a nitrogen atmosphere for 48 h. The cooled reaction mixture was then passed through a pad of TLC-grade silica and the filtrate concentrated under reduced pressure. The residue so formed was subjected to flash chromatography (silica, 30: 1 v/v hexane/ethyl acetate elution) to afford, after concentration of the appropriate fractions (Rf = 0.5 in 8: 1 v/v hexane/ethyl acetate), compound 38 (5.21 g, 99%) as a clear, colorless syrup. (0734) 1H NMR (400 MHz, CDCI3) £ 7.85 (d, J = 2.4 Hz, l H), 7.59 (dd, J = 8.5 and 2.4 Hz, 2H), 7.18 (m, 1H), 6.71 (m, 2H), 6.25 (m, 2H), 3.65 (s, 3H). (0735) 13C NMR (100 MHz, CDC13) delta 166.1 , 139.4, 135.3, 133.5, 129.4, 128.3, 122.0, 120.5, 1 10.2, 52.8. (0736) IR vmax 2950, 1729, 1594, 1563, 1498, 1435, 1400, 1329, 1288, 1267, 1238, 1 123, 1094, 1015, 966, 922, 826, 727 cm 1. (0737) MS (ESI, +ve): m/z 282 and 280 [(M+H) , both 50%], 250 and 248 (96 and 100). (0738) HRMS (ESI, +ve) Found: (M i l ) . 279.9972. C12Hi179BrN02 requires (M i l ) . 279.9973.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE AUSTRALIAN NATIONAL UNIVERSITY; BANWELL, Martin Gerhardt; ZHANG, Yiwen; (159 pag.)WO2017/100819; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 181765-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 181765-86-6 name is Methyl 5-bromo-2-iodobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 1 ,4-benzenediboronic acid bis(pinacol) ester (4.40 g, 13.33 mmol), methyl 2-iodo-5-bromobenzoate (9.95 g, 29.18 mmol), and Aliquat 336 (1.60 mL) was degassed 3 times with N2 before 90.0 mL of dry toluene was added. Tetrakis(triphenylphosphine)palladium (1.50 g, 1.30 mmol) and IM aqueous sodium carbonate solution (5.73 g in 54.0 mL of water) which was already deaerated for 2 hours were added under N2. The mixture was stirred vigorously and heated at the refluxing temperature for 2 days and allowed to cool to room temperature. The solution was passed through a plug of Celite to remove palladium black and the filtrate was concentrated to provide a residue, which was purified by column chromatography (silica gel, chloroform) to afford 4,4″-dibromo-2,2″- methoxycarbonyl-[l,l’;4′,l “]terphenyl (17) as a white solid (6.00 g, 89% yield). 1H NMR (CDCl3): delta 3.72 (s, 6H), 7.32(d, 2H, J = 8.0 Hz), 7.33 (s, 4H), 7.69(d, 2H, J = 8.0 Hz), 8.01 (s, 2H) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-bromo-2-iodobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; NORTHWESTERN UNIVERSITY; WO2009/17798; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 181765-86-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181765-86-6 as follows.

A. 5-Bromo-2-(trifluoromethyl)benzoate. To a solution of methyl 5- bromo-2-iodobenzoate (4.65 g, 13.64 mmol) and methyl 2,2-difluoro-2- (fluorosulfonyl)acetate (2.6 mL, 20.44 mmol) in N-methyl-2-pyrrolidinone (10 mL) was added copper(I) bromide (235 mg, 1.638 mmol). The reaction mixture was stirred at 120C for 15 h in a sealed tube. The reaction was partitioned between ethyl acetate and aqueous sodium chloride. The aqueous layer was extracted with ethyl acetate (3 x 25 mL), and the organic layers were combined and dried over magnesium sulfate. After filtration, the solvent was removed in vacuo. The residue was purified by silica gel chromatography (1-5% ethyl acetate in hexanes) to give the title compound as an oil (2.9 g, 10.25 mmol, 75% yield); 1H NMR (400 MHz, DMSOd6) delta 8.08 (s, IH), 8.01 (d, J= 8.20 Hz, IH), 7.83 (d, J= 8.20 Hz, IH), 3.90 (s, 3H).

According to the analysis of related databases, 181765-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2009/89042; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 181765-86-6

Add compound 7 (9.99 g, 29.4 mmol) to a 250 ml three-necked flaskAnd p-methoxyphenylboronic acid (5.36g, 35.28mmol),Then add 50ml of tetrahydrofuran and 50ml of water and stir,Add bistriphenylphosphonium palladium dichloride (1.03g, 1.47mmol) under a nitrogen atmosphere.When the temperature reached 60 C, sodium carbonate (6.23g, 58.8mmol) was added, and the reaction was refluxed for 12h.Cooled to room temperature, diluted with ethyl acetate, washed with saturated brine, and dried over anhydrous magnesium sulfate,After filtration, the solution was concentrated under reduced pressure and separated by column chromatography to obtain 7.53 g.Compound 8 was a white solid with a yield of 80%.

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dalian University of Technology; Wang Shisheng; Li Guangzhe; Liu Liqiang; Zhao Weijie; Guo Xiuhan; Li Yueqing; Wang Xu; Dong Huijuan; (21 pag.)CN110041200; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 181765-86-6, COA of Formula: C8H6BrIO2

Example 15B (5-Bromo-2-iodophenyl)methanol To a stirred mixture of NaBH4 (11.18 g, 0.296 mol) in EtOH (200 mL) at 5 C. was added the product from Example 15A (50.4 g, 0.148 mol) in THF (100 mL). The mixture was alowed to warm to room temperature and stirred for 18 hours. The mixture was treated with additional NaBH4 (8.4 g, 0.222 mol) and was stirred for 22 hours. The mixture was cooled to 0 C., treated with 100 mL of 15% aqueous citric acid slowly, and extracted with 600 mL of CH2Cl2. The organic phase was washed with 200 mL of 15% NaCl and concentrated to provide the title compound. 1H NMR (CDCl3, 400 MHz) delta 7.64 (d, J=8 Hz, 1H), 7.61 (d, J=4 Hz, 1H), 7.12 (dd, J=4, 8 Hz, 1H), 4.63 (d, J=8 Hz, 2H), 1.98 (t, J=8 Hz, 1H). MS (DCl/NH3) [M+NH4]+at 330, [M+NH4-H2O]+ at 312.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-2-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/272736; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 5-bromo-2-iodobenzoate

In a 500-mE round-bottom flask reactor, methyl5-bromo-2-iodobenzoate (25.0 g, 73 mmol), 4-dibenzofuran boronic acid (18.7 g, 88 mmol), tetrakis (triphenylphosphine)palladium (1.7 g, 0.15 mmol), and potassium carbonate (20.2 g, 146.7 mmol) were stirred together with toluene (125 mE), tetrahydrofuran (125 mE), and water (50 mE) for 10 hrs at 80 C. Afier completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ethyl acetate. The organic layer thus formed was separated, concentrated in a vacuum, and purified by column chromatography to afford . (75.0 g, 60.1%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 181765-86-6, its application will become more common.

Reference:
Patent; SFC CO., LTD.; KIM, Hee-Dae; PARK, Seok-Bae; SHIN, Yoona; LEE, Yu-Rim; PARK, Sang-Woo; CHA, Soon-Wook; (81 pag.)US2017/342318; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com