Category: 180258-46-2

Computed Properties of C7H12ClN3O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Sequence-specific DNA alkylation by hybrid molecules between segment A of Duocarmycin A and pyrrole/imidazole diamide. Author is Tao, Zhi-Fu; Fujiwara, Tsuyoshi; Saito, Isao; Sugiyama, Hiroshi.

The authors decide the preparation of novel hybrid mols. between segment A of duocarmycin A and pyrrole/imidazole diamides. These hybrids primarily alkylate the 3′ end of A in AT-rich sequences, as does the parent compound, duocarmycin. These hybrids also alkylate G residues of predetermined DNA sequences efficiently and with high specificity by formation of a heterodimer with distamycin A.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. published the article 《Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides》. Keywords: pyrrole imidazole polyamide oligomeric solution phase synthesis.They researched the compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride( cas:180258-46-2 ).Application In Synthesis of Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:180258-46-2) here.

A solution-phase alternative to typical solid-phase synthesis of pyrrole-imidazole polyamides, which are DNA-binding mols. programmable for a large repertoire of DNA sequences, is reported. An 8-ring hairpin polyamide, which targets the DNA sequence 5′-WGWWCW-3′, was chosen for this synthesis as this oligomer exhibits androgen receptor antagonism in cell culture models of prostate cancer. A convergent solution-phase synthesis of this polyamide from a small set of com. available building blocks presented highlights principles for preparing gram quantities of pyrrole-imidazole oligomers with minimal chromatog.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Sequence-specific DNA alkylation by hybrid molecules between segment A of Duocarmycin A and pyrrole/imidazole diamide, Author is Tao, Zhi-Fu; Fujiwara, Tsuyoshi; Saito, Isao; Sugiyama, Hiroshi, which mentions a compound: 180258-46-2, SMILESS is O=C(C1=NC(N)=CN1C)OCC.[H]Cl, Molecular C7H12ClN3O2, Recommanded Product: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride.

The authors decide the preparation of novel hybrid mols. between segment A of duocarmycin A and pyrrole/imidazole diamides. These hybrids primarily alkylate the 3′ end of A in AT-rich sequences, as does the parent compound, duocarmycin. These hybrids also alkylate G residues of predetermined DNA sequences efficiently and with high specificity by formation of a heterodimer with distamycin A.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker.Safety of Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride.

Two novel guanidiniocarbonyl pyrrole-pyrene conjugates III and IV as spectroscopic probes for ds-polynucleotides were synthesized and their interaction with different ds-DNAs/RNAs studied. Compared to a previously reported first set of conjugates (I and II) the significant extension and increased rigidity of the central part of the structure resulted in a switch of DNA binding mode from intercalative (previously studied derivatives I and II with a nonbinding and flexible linker) to minor groove binding of the two novel guanidiniocarbonyl-pyrrole-pyrene conjugates III and IV. These two compounds interact strongly with ds-DNAs, but only weakly with ds-RNA. The newly incorporated heterocyclic moieties within the central part of the structure of III and IV were able to control by steric and hydrogen-bonding effects the alignment of the mols. within various, structurally different forms of DNA minor grooves, whereby even small differences in the position of the attached pyrene within the groove were reflected in different fluorimetric responses. In addition, III and IV revealed intriguing in vitro selectivity among various human tumor cell lines.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C7H12ClN3O2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Author is Harki, Daniel A.; Satyamurthy, Nagichettiar; Stout, David B.; Phelps, Michael E.; Dervan, Peter B..

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small mols. that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments The 18F-radiolabeled polyamides were prepared by oxime ligation between 4-[18F]-fluorobenzaldehyde and a hydroxylamine moiety at the polyamide C terminus. Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differences in the biodistribution of a 5-ring β-linked polyamide vs. an 8-ring hairpin, which exhibited better overall bioavailability. In vivo imaging of pyrrole-imidazole polyamides by PET is a min. first step toward the translation of polyamide-based gene regulation from cell culture to small animal studies.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=NC(N)=CN1C)OCC.[H]Cl)Synthetic Route of C7H12ClN3O2, and with the development of science, more effects of this compound(180258-46-2) can be discovered.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C7H12ClN3O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker.

Two novel guanidiniocarbonyl pyrrole-pyrene conjugates III and IV as spectroscopic probes for ds-polynucleotides were synthesized and their interaction with different ds-DNAs/RNAs studied. Compared to a previously reported first set of conjugates (I and II) the significant extension and increased rigidity of the central part of the structure resulted in a switch of DNA binding mode from intercalative (previously studied derivatives I and II with a nonbinding and flexible linker) to minor groove binding of the two novel guanidiniocarbonyl-pyrrole-pyrene conjugates III and IV. These two compounds interact strongly with ds-DNAs, but only weakly with ds-RNA. The newly incorporated heterocyclic moieties within the central part of the structure of III and IV were able to control by steric and hydrogen-bonding effects the alignment of the mols. within various, structurally different forms of DNA minor grooves, whereby even small differences in the position of the attached pyrene within the groove were reflected in different fluorimetric responses. In addition, III and IV revealed intriguing in vitro selectivity among various human tumor cell lines.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=NC(N)=CN1C)OCC.[H]Cl)COA of Formula: C7H12ClN3O2, and with the development of science, more effects of this compound(180258-46-2) can be discovered.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Benzoisothiazolone Organo/Copper-Cocatalyzed Redox Dehydrative Construction of Amides and Peptides from Carboxylic Acids using (EtO)3P as the Reductant and O2 in Air as the Terminal Oxidant, the main research direction is amide peptide preparation; benzoisothiazolone preparation cocatalyst copper redox dehydrative amidation.Computed Properties of C7H12ClN3O2.

Carboxylic acids and amine/amino acid reactants can be converted to amides and peptides at neutral pH within 5-36 h at 50° using catalytic quantities of a redox-active benzoisothiazolone and a copper complex. These catalytic “”oxidation-reduction condensation”” reactions are carried out open to dry air using O2 as the terminal oxidant and a slight excess of tri-Et phosphite as the reductant. Tri-Et phosphate is the easily removed byproduct. These simple-to-run catalytic reactions provide practical and economical procedures for the acylative construction of C-N bonds.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com