Category: 1774-47-6

In 2022,Mahesh Kumar, Avula; Venkateshwarlu, Rapolu; Tadiparthi, Krishnaji; Rao, B. Venkateswara; Kota Balaji, Shiva Kumar; Raghunadh, Akula; Singh, Shambhu Nath published an article in Synthetic Communications. The title of the article was 《A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride》.Product Details of 1774-47-6 The author mentioned the following in the article:

A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride was reported. The key features of the synthesis involve the asym. reduction of ketone using (S)-CBS oxazaborolidine and the use of com. available Me pyroglutamate as a starting material. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application In Synthesis of Trimethylsulfoxonium iodideIn 2020 ,《Regioselective Bronsted Acid-Catalyzed Annulation of Cyclopropane Aldehydes with N’-Aryl Anthranil Hydrazides: Domino Construction of Tetrahydropyrrolo[1,2-a]quinazolin-5(1H)ones》 appeared in Journal of Organic Chemistry. The author of the article were Singh, Priyanka; Kaur, Navpreet; Banerjee, Prabal. The article conveys some information:

A highly regioselective synthesis of tetrahydropyrrolo[1,2-a]quinazolin-5(1H)one derivatives was achieved by reacting cyclopropane aldehydes with N’-aryl anthranil hydrazides in the presence of p-toluenesulfonic acid (PTSA). The transformation involves domino imine formation and intramol. cyclization to form 2-arylcyclopropyl-2,3-dihydroquinazolin-4(1H)-one, followed by nucleophilic ring opening of the cyclopropyl ring to form desired tetrahydropyrrolo[1,2-a]quinazolin-5(1H)one in good to excellent yield with complete regioselectivity. This protocol tolerates a great variety of functional groups and thus provides a simple and step-efficient method for pyrroloquinazolinone synthesis. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Application In Synthesis of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Application In Synthesis of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,European Journal of Organic Chemistry included an article by Luo, Yi; Guo, Lingmei; Yu, Xinling; Ding, Haosheng; Wang, Huijing; Wu, Yong. Application of 1774-47-6. The article was titled 《Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2-aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C-H Bond Activation》. The information in the text is summarized as follows:

The iridium-catalyzed aromatic C-H alkylation followed by intramol. annulation reactions between N-aryl-2-aminopyridines and sulfoxonium ylides for the synthesis of 2-alkyl indoles is described. This highly efficient and step-economical cyclization reaction displays excellent functional group compatibility and regioselectivity. Afterwards, the directing group in C-H alkylation can be readily removed to obtain the free N-H indoles. Thus, the sulfoxonium ylide, a carbene precursor, is proved as a useful surrogate of diazo compounds in C-H activation chem. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Application of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Application of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Advanced Synthesis & Catalysis included an article by Dey, Raghunath; Banerjee, Prabal. Product Details of 1774-47-6. The article was titled 《Metal-Free Ring Opening Cyclization of Cyclopropane Carbaldehydes and N-Benzyl Anilines: An Eco-Friendly Access to Functionalized Benzo[b]azepine Derivatives》. The information in the text is summarized as follows:

In the presence of 0.2 equivalent or 1.2 equivalent of p-TsOH, arylcyclopropanecarboxaldehydes such as I and a bicycloheptanecarboxaldehyde underwent ring opening or tandem ring opening and cyclocondensation reactions with N-benzylic anilines such as II at ambient temperature in CH2Cl2 to yield either γ-aryl-γ-(arylamino)butanals such as III and arylbenzazepines such as IV, resp. IV was reduced to the corresponding tetrahydrobenzazepine. In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as dual μ-opioid receptor agonists and σ1 receptor antagonists for the treatment of pain》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Garcia, Monica; Virgili, Marina; Alonso, Monica; Alegret, Carles; Fernandez, Begona; Port, Adriana; Pascual, Rosalia; Monroy, Xavier; Vidal-Torres, Alba; Serafini, Maria-Teresa; Vela, Jose Miguel; Almansa, Carmen. Category: iodides-buliding-blocks The article mentions the following:

The synthesis and pharmacol. activity of a new series of 1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the sigma-1 receptor (σ1R) and the μ-opioid receptor (MOR) are reported. The different positions of the central scaffold, designed using a merging strategy of both targets pharmacophores, were explored using a versatile synthetic approach. Phenethyl derivatives in position 9, substituted pyridyl moieties in position 4 and small alkyl groups in position 2 provided the best profiles. One of the best compounds, I, showed a balanced dual profile (i.e. MOR agonism and sigma antagonism) and potent analgesic activity, comparable to the MOR agonist oxycodone in the paw pressure test in mice. Contrary to oxycodone, as expected from the addition of σ1R antagonism, I showed local, peripheral activity in this test, which was reversed by the σ1R agonist PRE-084. At equianalgesic doses, I showed less constipation than oxycodone, providing evidence that dual MOR agonism and σ1R antagonism may be a useful strategy for obtaining potent and safer analgesics. The experimental part of the paper was very detailed, including the reaction process of Trimethylsulfoxonium iodide(cas: 1774-47-6Category: iodides-buliding-blocks)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 1774-47-6In 2021 ,《Rhodium(III)-Catalyzed Cross-Coupling of Sulfoxonium Ylides with Quinoline-8-carboxaldehydes for Synthesis of Quinoline-1,3-diketones》 appeared in Asian Journal of Organic Chemistry. The author of the article were Lyu, Xue-Li; Huang, Shi-Sheng; Huang, Yuan-Qiong; Song, Hong-Jian; Liu, Yu-Xiu; Li, Yong-Qiang; Yang, Shao-Xiang; Wang, Qing-Min. The article conveys some information:

Herein, a protocol for rhodium(III)-catalyzed aldehydic C(sp2)-H acylmethylation reactions of quinoline-8-carboxaldehydes I (R = H, 6-(4-methoxyphenyl), 5-(naphthalen-1-yl), etc.) using sulfoxonium ylides R1C(O)CH=S(O)Me2 (R1 = Ph, propan-2-yl, adamantan-1-yl, etc.) as carbene precursors to afford 1,3-diketones II, which readily tautomerized to their enol forms was reported. The reaction mechanism was determined by synthesizing the key intermediate, a five-membered-ring acylrhodium species were determinedTrimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tian, Yu; Zhang, Zunting; Wang, Tao published an article in 2021. The article was titled 《Synthesis of Isatin-Hydrazones from 3-Diazo Oxindoles and Sulfoxonium Ylides under Catalyst- and Additive-Free Conditions》, and you may find the article in European Journal of Organic Chemistry.SDS of cas: 1774-47-6 The information in the text is summarized as follows:

A facile synthesis of isatin-hydrazones from 3-diazo oxindoles and sulfoxonium ylides under catalyst- and additive-free conditions is described. A plausible reaction pathway is proposed for the transformation, in which diazo compounds play as electrophiles to react with nucleophilic sulfoxonium ylides. The reaction mechanism is supported by the exptl. evidence.Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Day, David Philip; Mora Vargas, Jorge Andres; Burtoloso, Antonio Carlos Bender published an article in 2021. The article was titled 《Direct Synthesis of α-Fluoro-α-Triazol-1-yl Ketones from Sulfoxonium Ylides: A One-Pot Approach》, and you may find the article in Journal of Organic Chemistry.SDS of cas: 1774-47-6 The information in the text is summarized as follows:

The work reported herein showcases a new route to access α-fluoro-α-triazol-1-yl ketones I [R1 = t-Bu, Ph, 2,4,6-tri-ClC6H2, etc.; R2 = t-Bu, Ph, 4-MeC6H4, etc.] from sulfoxonium ylides via α-azido-α-fluoro ketone intermediates. In a one-pot, two-step sequence, the ketosulfoxonium reactant initially underwent insertion of F+ and N3-, followed by a subsequent CuAAC reaction with arylacetylenes to install a 1,4-triazolo moiety. The approach allowed for modification to both the sulfoxonium ylide and arylacetylene reactants. Fifteen examples had been reported, with yields ranging between 22%-75%.Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Ruthenium(II)-Catalyzed Homocoupling of Weakly Coordinating Sulfoxonium Ylides via C-H Activation/Annulations: Synthesis of Functionalized Isocoumarins》 were Zhou, Ming-Dong; Peng, Zhen; Wang, He; Wang, Zhao-Hui; Hao, Da-Jin; Li, Lei. And the article was published in Advanced Synthesis & Catalysis in 2019. Product Details of 1774-47-6 The author mentioned the following in the article:

Homocoupling of weakly coordinating sulfoxonium ylides was accomplished via a ruthenium(II) catalyzed C-H activation process. This strategy provides a convenient, efficient and step-economic method to access 3-substituted isocoumarins with good functional group tolerance. The sulfoxonium ylide acts both as the convenient aromatic substrate and the acylmethylation reagent in this transformation. Moreover, the products could be transformed into diverse valuable derivatives In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium-Catalyzed Synthesis of α-Carbonyl-α’-(Hetero)aryl Sulfoxonium Ylides: Scope and Insight into the Mechanism》 was published in Journal of Organic Chemistry in 2020. These research results belong to Janot, Christopher; Chagnoleau, Jean-Baptiste; Halcovitch, Nathan R.; Muir, James; Aissa, Christophe. Recommanded Product: Trimethylsulfoxonium iodide The article mentions the following:

Despite recent advances, a general method for the synthesis of α-carbonyl-α’-(hetero)aryl sulfoxonium ylides is needed to benefit more greatly from the potential safety advantages offered by these compounds over the parent diazo compounds Herein, the palladium-catalyzed cross-coupling of aryl bromides and triflates with α-carbonyl sulfoxonium ylides is reported. The use of this method for the modification of an active pharmaceutical ingredient and to the synthesis of a key precursor of antagonists of the neurokinin-1 receptor is also reported. In addition, the mechanism of the reaction was inferred from several observations. Thus, the oxidative addition complex [(XPhos)PhPdBr] and its dimer were observed by 31P{1H} NMR and these complexes were shown to be catalytically and kinetically competent. Moreover, a complex resulting from the transmetallation of [(XPhos)ArPdBr] (Ar = p-CF3-C6H4) with a model sulfoxonium ylide was observed by mass spectrometry. Finally, the partial rate law suggests that the transmetallation of and the subsequent deprotonation are rate-determining in the catalytic cycle. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Recommanded Product: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com