Category: 1774-47-6

Zhao, Yi; Zhao, Ze; Cui, Yamin; Chen, Xing; Chen, Changqing; Xie, Changwei; Qin, Bo; Yang, Yang published an article in 2021. The article was titled 《Redox-responsive glycosylated combretastatin A-4 derivative as novel tubulin polymerization inhibitor for glioma and drug delivery》, and you may find the article in Drug Development Research.Synthetic Route of C3H9IOS The information in the text is summarized as follows:

Combretastatin A-4 (CA4), a tubulin inhibitor, binds to the colchicine site of tubulin, inhibits tubulin polymerization, and leads to the apoptosis of tumor cells. However, the poor hydrophilicity and blood-brain barrier (BBB) penetration ability of CA4 hampers its application in the treatment of glioma. In this study, a novel combretastatin A-4 derivative (CA4D) was designed and developed, which was further conjugated with glucose via disulfide-bond-bridged (CA4D-SS-Glu) to enhance the BBB penetration capacity. The obtained CA4D-SS-Glu conjugate displayed a suitable water partition coefficient and the superior ability across BBB in vitro and in vivo. In addition, the CA4D-SS-Glu exhibited rapid redox-responsive drug release in the presence of glutathione, enhanced in vitro cytotoxicity, and cell apoptosis. Our data further confirmed that CA4D-SS-Glu inhibited proliferation, and restrained migration via affecting microtubule stabilization. Addnl., the conjugate also showed the highest antiproliferative and antitumor action on glioma in vivo as compared to CA4D and CA4. Taken together, the novel CA4D-SS-Glu conjugate possess improved physicochem. property and BBB penetration ability, reduction triggered release of CA4D, and efficient antiproliferative activity. These results provided a novel and effective entry to the treatment of glioma. In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Synthetic Route of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C3H9IOSIn 2019 ,《Rhodium-catalyzed C-H activation/cyclization of enaminones with sulfoxonium ylides toward polysubstituted naphthalenes》 appeared in Tetrahedron Letters. The author of the article were Wang, Zhenlian; Xu, Huang. The article conveys some information:

A rhodium-catalyzed ortho-C-H functionalization and annulation between enaminones and sulfoxonium ylides was developed, affording a series of multi-substituted naphthalenes I [R = H, 6-MeO, 6-CF3, etc.; Ar = Ph, 4-ClC6H4, 2-thienyl, etc.] in good to moderate yields with excellent functional group compatibility. The procedure featured with enaminone acting as both a directing and cyclization bifunctional group and the application of sulfoxonium ylide in C-H functionalization. After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Synthetic Route of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Oxidative organocatalysed enantioselective coupling of indoles with aldehydes that forms quaternary carbon stereocentres》 were Rezayee, Nomaan M.; Lauridsen, Vibeke H.; Naesborg, Line; Nguyen, Thanh V. Q.; Tobiesen, Henriette N.; Joergensen, Karl Anker. And the article was published in Chemical Science in 2019. Recommanded Product: Trimethylsulfoxonium iodide The author mentioned the following in the article:

The first organocatalyzed, metal-free cross-nucleophile coupling of indoles with α-branched aldehydes forming acyclic stereoselective quaternary carbon centers was presented. Applying an amino acid-derived catalyst with suitable organic oxidants afforded the desired enantioenriched indole functionalized products with moderate to excellent yield and enantioselectivity. Two metal-free oxidative protocols employing either DDQ or a sequential approach that uses two organocatalysts to facilitate the use of O2 as the terminal oxidant were disclosed. These methods were compatible with various indoles ranging from electron-rich to -deficient substituents at the C-2,-5,-6 and -7-positions reacting with a series of different α-branched aldehydes. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Recommanded Product: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic Chemistry Frontiers included an article by Cai, Libo; Zhu, Xiaoyi; Chen, Jiayi; Lin, Aijun; Yao, Hequan. Reference of Trimethylsulfoxonium iodide. The article was titled 《Rh(III)-Catalyzed C-H activation/annulation of salicylaldehydes with sulfoxonium ylides for the synthesis of chromones》. The information in the text is summarized as follows:

A rhodium(III)-catalyzed C-H activation/annulation of salicylaldehydes e.g., 2-OHC6H4CHO with sulfoxonium ylides RC(O)CH=S(O)(CH3)CH3 (R = Ph, t-Bu, cyclohexyl, thiophen-2-yl, etc.) has been developed for the formation of 2-substituted chromones e.g., I in good yields with broad functional group tolerance. The utility of this strategy was showcased by the late-stage modification of some biol. active mols. Moreover, structurally diverse 2,3-disubstituted chromones II (R1 = Cl, CF3, diethoxyphosphoroso, etc.) were also constructed by the C3 C-H functionalization reactions.Trimethylsulfoxonium iodide(cas: 1774-47-6Reference of Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Reference of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Multi-step continuous flow synthesis of fluconazole》 were Szeto, Judy; Vu, Vi-Anh; Malerich, Jeremiah P.; Collins, Nathan. And the article was published in Journal of Flow Chemistry in 2019. SDS of cas: 1774-47-6 The author mentioned the following in the article:

The development of a flow chem. approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification The synthesis has been successfully demonstrated on a Vaportec com. flow chem. system. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Transition-Metal-, Additive-, and Solvent-Free [3+3] Annulation of RCF2-Imidoyl Sulfoxonium Ylides with Cyclopropenones to Give Multifunctionalized CF3-Pyridones》 was written by Wen, Si; Chen, Yanhui; Tian, Qingyu; Zhang, Yuqing; Cheng, Guolin. Product Details of 1774-47-6This research focused ontriaryl trifluoromethylpyridone preparation green chem; imidoyl sulfoxonium ylide cyclopropenone annulation. The article conveys some information:

An efficient and practical strategy was developed to synthesize 1,3,4-triaryl-6-trifluoromethylpyridones from CF3-imidoyl sulfoxonium ylides and cyclopropenones in good to excellent yields. This stepwise [3+3] annulation reaction was carried out under transition-metal-, additive-, and solvent-free conditions, generating 1 equiv of DMSO as byproduct and tolerating a series of functional groups. The experimental part of the paper was very detailed, including the reaction process of Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C3H9IOSIn 2020 ,《Imidazol-5-one as an Acceptor in Donor-Acceptor Cyclopropanes: Cycloaddition with Aldehydes》 was published in Organic Letters. The article was written by Mikhaylov, Andrey A.; Kuleshov, Andrei V.; Solyev, Pavel N.; Korlyukov, Alexander A.; Dorovatovskii, Pavel V.; Mineev, Konstantin S.; Baranov, Mikhail S.. The article contains the following contents:

Spiro[imidazol-5-one-4,1′-cyclopropanes] behave as donor-acceptor (D-A) cyclopropanes in a formal cycloaddition reaction with aldehydes. The activation of such type of cyclopropanes is achieved with an equivalent of Bronsted acid. The reaction proceeds in high yields of 51-92% and demonstrates moderate diastereoselectivity at the quaternary stereocenter, which is determined by the electron-donating nature of the aldehyde partner. The ease of separation of stereoisomers allowed the creation of a library of 44 spiroannulated tetrahydrofurans with various substitution patterns. After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6COA of Formula: C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.COA of Formula: C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application In Synthesis of Trimethylsulfoxonium iodideIn 2021 ,《Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas》 was published in Chinese Chemical Letters. The article was written by Chen, Yuncan; Lv, Shan; Lai, Ruizhi; Xu, Yingying; Huang, Xin; Li, Jianglian; Lv, Guanghui; Wu, Yong. The article contains the following contents:

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, provided a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Application In Synthesis of Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Application In Synthesis of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic Letters included an article by Tukhtaev, Hamidulla B.; Ivanov, Konstantin L.; Bezzubov, Stanislav I.; Cheshkov, Dmitry A.; Melnikov, Mikhail Ya.; Budynina, Ekaterina M.. Computed Properties of C3H9IOS. The article was titled 《aza-Wittig Reaction with Nitriles: How Carbonyl Function Switches from Reacting to Activating》. The information in the text is summarized as follows:

Transformations of α-EWG-substituted (electron-withdrawing group, EWG) γ-azidobutyronitriles proceeding via unusual aza-Wittig reactions between the phosphazene and nitrile functions and affording pyrrole-derived iminophosphazenes were developed. α-EWGs were found to control chemoselectivity and, depending on their nature, act as CN group activators (e.g., ester, amide, or nitrile) or competitors (e.g., ketone) in aza-Wittig reactions. To demonstrate the synthetic utility of the obtained iminophosphazenes as N,N-binucleophiles, their transformations into pyrrole-fused systems, pyrrolo[1,2-a]imidazoles and pyrrolo[1,2-a][1,3]diazepines, were carried out. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Computed Properties of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Computed Properties of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Anode interfacial layer formation via reductive ethyl detaching of organic iodide in lithium-oxygen batteries》 were Zhang, Xiao-Ping; Sun, Yi-Yang; Sun, Zhuang; Yang, Chu-Shu; Zhang, Tao. And the article was published in Nature Communications in 2019. Electric Literature of C3H9IOS The author mentioned the following in the article:

As soluble catalysts, redox mediators can reduce the high charging overpotential of lithium-oxygen batteries by providing sufficient liquid-solid interface for lithium peroxide decomposition However, the redox mediators usually introduce undesirable reactions. In particular, the so-called “”shuttle effect”” leads to the loss of both the redox mediators and elec. energy efficiency. In this study, an organic compound, triethylsulfonium iodide, is found to act bifunctionally as both a redox mediator and a solid electrolyte interphase-forming agent for lithium-oxygen batteries. During charging, the organic iodide exhibits comparable lithium peroxide-oxidizing capability with inorganic iodides. Meanwhile, it in situ generates an interfacial layer on lithium anode via reductive Et detaching and the subsequent oxidation This layer prevents the lithium anode from reacting with the redox mediators and allows efficient lithium-ion transfer leading to dendrite-free lithium anode. Significantly improved cycling performance has been achieved by the bifunctional organic iodide redox mediator. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Electric Literature of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Electric Literature of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com