Category: 173406-17-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 173406-17-2 as follows. Recommanded Product: 173406-17-2

To a mixture of 244 mg of 3- (2-aminoetliyl) pyridine (2.0 mmol) and 604 mg of t-butyl 3- iodobenzoate (2.0 mmol) in 10 [ML] of toluene was added 250 mg of sodium t-butoxid (2.5 [MMOL),] 30 mg [OF TRI-T-BUTYLPHOSPLIONIMN TETAFLUOROBORATE] (0.1 mmol) and 50 mg of tris (dibenzylidineacetone) dipalladium [(0)] (0.055 [MMOL).] The mixture was stirred for 16 h and filtered through celite. The celite was washed with 3 X 5 mL of toluene and the filtrate was concentrated in vacuo. The residue was purified by column [CHROMATOGRAPHY] using 35%-45% EtOAc in hexanes as eluant to give 103 mg of t-butyl N- (2- (3-pyridyl) ethyl)-3-aminobenzoate as a bright yellow oil (17% yield).

According to the analysis of related databases, 173406-17-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2004/9552; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 173406-17-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 173406-17-2, name is tert-Butyl 3-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 8B; tert-Butyl 3-[N-(3-Chloro-4-methoxyphenyl)-pyridin-3-ylmethylamino] benzoate; To a solution of 3-chloro-4-methoxyphenyl-N- (3-pyridylmethyl) amine (248 mg, 1 mmol) and t- butyl 3-iodobenzoate (450 mg, 1.5 mmol) in 10 mL toluene was added NaOtBu (150 mg, 1.5 mmol), Pd2dba3 (18 mg, 0.02 mmol), and P (tBu) 3HBF4 (12 mg, 0.04 mmol). The mixture was stirred overnight then filtered through celite and loaded onto a silica column (12g). The product was eluted with a linear gradient from 30% to 45% EtOAc in hexanes to give tert-Butyl 3-[N-(3- Chloro-4-methoxyphenyl)-pyridin-3-ylmethylamino] benzoate as a yellow oil.

The synthetic route of tert-Butyl 3-iodobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2005/61458; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com