Category: 173043-61-3

Adding a certain compound to certain chemical reactions, such as: 173043-61-3, name is Methyl 2-iodo-4,5-dimethoxybenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 173043-61-3, Product Details of 173043-61-3

General procedure: A dry, N2 flushed 25 mL round-bottomed flask, equipped with a magnetic stirring bar, was charged with aryl iodide 3 (1 mmol) in anhydrous THF (5 mL), and cooled to -40 C. i-PrMgCl (2 M in THF, 2 mmol) was slowly added. After 0.5 h, CuCN·2LiCl (premixed CuCN and 1 M LiCl in THF) (0.1 mmol) was added. After 5 min, at the same temperature, 2-chloro-3-iodo-propene (2 mmol) was added and the reaction mixture allowed to warm to rt. The reaction mixture was quenched with sat. NH4Cl (20 mL) and extracted with MTBE (2 × 20 mL). The combined organic fractions were washed with brine (10 mL), then dried over Na2SO4, and concentrated in vacuo. The crude product was used in the next step after a silica plug treatment or without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-iodo-4,5-dimethoxybenzoate, and friends who are interested can also refer to it.

Reference:
Article; Linghu, Xin; McLaughlin, Mark; Chen, Cheng-Yi; Reamer, Robert A.; Dimichele, Lisa; Davies, Ian W.; Tetrahedron Letters; vol. 53; 13; (2012); p. 1550 – 1552;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 173043-61-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 173043-61-3, name is Methyl 2-iodo-4,5-dimethoxybenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of ester (10 mmol) in DMF was added indole (10 mmol), CuI (10 mol %) and K2CO3 (30 mmol). The resultant mixture was stirred at 120 oC for 2 h. After completion, the reaction mixture was filtered through celite. The filtrate was extracted with EtOAc, washed with water, brine, and dried over Na2SO4. The solution was concentrated under reduced pressure, and purified by column chromatographed over silica gel to give the desired 2-indolyl ester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-iodo-4,5-dimethoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Min; Liu, Yu-Wen; Xu, Hui; Dai, Hui-Xiong; Tetrahedron Letters; vol. 60; 39; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com