Category: 170112-66-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, A new synthetic method of this compound is introduced below., name: 3,4,5-Trifluoroiodobenzene

b) 6- (3 ,4,5-trifluorophenyl)- 8- ((2- (trimethylsilyl)ethoxy)methoxy)-3- ((2- (trimethylsilyl)ethoxy)methyl)guinazolin-4(3H)-oneA solution of 6-(4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 8- ((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one(0.3g, 0.55 mmol) and 1,2,3-trifluoro-5-iodobenzene (0.18 g, 0.71 mmol) in dioxane (5 ml) was treated with bis(diphenylphosphino)feffocene-palladium(II)dichloride (0.04 g, 0.055 mmol). Aqueous 2M potassium carbonate solution (0.5 ml) was added and the reaction mixture was stuffed at 100 C for 16 hours. After extractive workup (ethyl acetate / water) the organic phasewas dried (Na2SO4), adsorbed on silica and chromatographed (silica gel, heptane / ethyl acetate =90:10 to 50:50) and triturated with hexane to furnish the title compound as a white solid (0.06 g,20%).MS: mle= 553.3 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BISSANTZ, Caterina; BONNAFOUS, Rene; BUETTELMANN, Bernd; JAKOB-ROETNE, Roland; LERNER, Christian; RUDOLPH, Markus; WO2014/102233; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 3,4,5-Trifluoroiodobenzene

b) 6- (3 ,4,5-trifluorophenyl)- 8- ((2- (trimethylsilyl)ethoxy)methoxy)-3- ((2- (trimethylsilyl)ethoxy)methyl)guinazolin-4(3H)-oneA solution of 6-(4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 8- ((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one(0.3g, 0.55 mmol) and 1,2,3-trifluoro-5-iodobenzene (0.18 g, 0.71 mmol) in dioxane (5 ml) was treated with bis(diphenylphosphino)feffocene-palladium(II)dichloride (0.04 g, 0.055 mmol). Aqueous 2M potassium carbonate solution (0.5 ml) was added and the reaction mixture was stuffed at 100 C for 16 hours. After extractive workup (ethyl acetate / water) the organic phasewas dried (Na2SO4), adsorbed on silica and chromatographed (silica gel, heptane / ethyl acetate =90:10 to 50:50) and triturated with hexane to furnish the title compound as a white solid (0.06 g,20%).MS: mle= 553.3 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BISSANTZ, Caterina; BONNAFOUS, Rene; BUETTELMANN, Bernd; JAKOB-ROETNE, Roland; LERNER, Christian; RUDOLPH, Markus; WO2014/102233; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 170112-66-0, Safety of 3,4,5-Trifluoroiodobenzene

3, 4, 5-trifluoroiodobenzene (10.0 g, 38.0 mmol), ethyl bromodifluoroacetate (23.1 g, 114 mmol)And copper (2.90 g, 45.6 mmol)Of dimethyl sulfoxide solution (40 ml)Was stirred at 80 C. for 3 hours. Ethyl acetate was added to the reaction mixture, and insoluble matter was filtered off. Water was poured into the filtrate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography (elution solvent: ethyl acetate / n-hexane = 1/10) to give the title compound as a colorless oil (yield 7.20 g, yield 75%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Hokko Chemical Industry Co., Ltd.; Suzuki, Jun; Wakabayashi, Jin; Murakami, Hideyuki; Onoue, Shinji; (19 pag.)JP2016/84348; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 170112-66-0

General procedure: A Schlenk tube was dried using heat gun under reduced pressure and filled with argon. The tube was charged with TPPO (69.5mg, 0.25mmol) and then the tube was evacuated and refilled with argon (×3). To the tube were added THF (1mL), Me2Zn (0.6mL, 0.6mmol, 1.0M solution in hexane), and fluoroarene 1 (0.75mmol) at room temperature and then the tube was immersed in an oil bath. The reaction mixture was gradually warmed to 75C and stirred for 3h. The mixture was cooled to room temperature and allylic bromide (0.5mmol) was added. The resultant mixture was warmed to 75C and stirred for 16h. The reaction mixture was quenched with saturated aqNH4Cl solution followed by extraction with Et2O (×3). Combined organic layer was washed with brine (×1), dried over Na2SO4, and filtered. Volatiles were removed under reduced pressure and the residue was purified by flash column chromatography on silica gel to afford analytically pure product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 170112-66-0.

Reference:
Article; Kurauchi, Daisuke; Hirano, Keiichi; Kato, Hisano; Saito, Tatsuo; Miyamoto, Kazunori; Uchiyama, Masanobu; Tetrahedron; vol. 71; 35; (2015); p. 5849 – 5857;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 170112-66-0

Set up a reflux reaction device and put a stirrer into the reaction bottle. 4-propylbiphenylacetylene, 1,2,6-trifluoro-4-iodobenzene, Catalyst Pd(Pph3)4 and cuprous iodide; Replace the air in the sealing system with argon; inject triethylamine, Tetrahydrofuran, stir and slowly heat to reflux. Make sure the system reacts under argon protection. After 7 hours, the degree of reaction was measured by TLC. Step 2), purify the crude product of step 1) with a cable extractor: After the reaction is completed, the reaction solution is poured into ice water, and dilute hydrochloric acid is added dropwise and stirred. Drip into weakly alkaline; extract the above liquid with dichloromethane, collect the organic phase, The organic phase is washed twice with brine and then dried over anhydrous sodium sulfate or anhydrous magnesium sulfate Dry, finally, rotary evaporation of the dry organic phase to give a brown solid. At this time, the brown solid is the crude product of the sonoshihira reaction. Contains target products, self-coupling by-products, and other by-products. Set up the extraction device and pour it in the extraction bottle of the Soxhlet extractor. Into petroleum ether; the brown solid is placed in a filter paper tube, Place the filter paper tube in the extraction tube of the Soxhlet extractor; Heat and reflux for 1-2 hours, and cool the petroleum ether of the extraction bottle to room temperature or lower. The product solid precipitated and was filtered using a suction device. A product having a purity of 95% or more is obtained.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 170112-66-0.

Reference:
Patent; Shenzhen Chao Duowei Technology Co., Ltd.; Zhang Guoxian; Bao Rui; (18 pag.)CN106398714; (2018); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

170112-66-0, name is 3,4,5-Trifluoroiodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H2F3I

General procedure: Arene (0.10 mmol, 1.0 equiv), Pd(OAc)2 (2.2 mg, 10 mumol,10 mol%), ligand (15 mol% or 20 mol%), hydrogen phosphate (15 mol% for benzylamine substrate), aryl iodide (0.3 mmol, 3.0 equiv.) and silver acetate (50 mg, 0.30 mmol, 3.0 equiv.) were added into a 2-dram reaction vial. Solvent and (+)-NBE-CO2Me (20 mol% or 50 mol%) were added to the mixture. The vial was flushed with N2 and capped. The reaction mixture was then stirred at the selected temperature for 12-24 h. After cooling to room temperature, the mixture was filtered through Celite and eluted with ethyl acetate. The filtrate was evaporated under reduced pressure. Purification by preparative thin-layer chromatography afforded the desired product.

The synthetic route of 170112-66-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shi, Hang; Herron, Alastair N.; Shao, Ying; Shao, Qian; Yu, Jin-Quan; Nature; vol. 558; 7711; (2018); p. 581 – 585;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 170112-66-0, The chemical industry reduces the impact on the environment during synthesis 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, I believe this compound will play a more active role in future production and life.

(S) -2- (1 ,3-Dioxoisoindolin-2-yl) -Itf-methoxy- 3- (3 , 4 , 5-trifluorophenyl) ropanamide (28s) The starting material 25 (10.0 mmol, 2.48 g) , Pd(OAc)2 (1.50 mmol, 337 mg) , and AgOAc (20.0 mmol, 3.34 g) were weighed in air and placed in a sealed tube (350 mL) with a magnetic stir bar. To the reaction mixture, aryl iodide (15 mmol), 2,6- lutidine (3.00 mmol, 0.3 mL) , and HFIP (100 mL) were added. The reaction mixture was first stirred at room temperature for 10 minutes and then heated to 90 C for 36 hours under vigorous stirring. Upon completion, the reaction mixture was cooled to room temperature, and HFIP was recovered by distillation. The residue was filtered with DCM and concentrated as crude product 28s.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trifluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; YU, Jin-Quan; WO2015/131100; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, molecular formula is C6H2F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3,4,5-Trifluoroiodobenzene

Method for preparing ethyl 2,2-difluoro-2- (3,4,5-trifluorophenyl) acetate 3,4,5-trifluoroiodobenzene (10.0 g, 38.0 mmol),Ethyl bromodifluoroacetate (23.1 g, 114 mmol)And a solution of copper (2.90 g, 45.6 mmol) in dimethylsulfoxide (40 ml)Was stirred at 80 C. for 3 hours. Ethyl acetate was added to the reaction mixture, and insoluble matter was filtered off. Pour water into the filtrate,And extracted with ethyl acetate. The extract was washed with saturated brine,After drying with anhydrous sodium sulfate,And concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography (elution solvent: ethyl acetate / n-hexane = 1/10) to give the title compound as a colorless oil (yield 7.20 g, yield 75%). J = 7.3 Hz), 1.31 (3H, t, J = 7.3 Hz), 1 H NMR spectrum (CDCl 3) sigma: 7.26 (2H, t, J = 6.9 Hz), 4.31 ).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 170112-66-0, its application will become more common.

Reference:
Patent; Hokko Chemical Industry Co., Ltd.; Suzuki, Jun; Kobayashi, Yuta; Murakami, Hideyuki; Ono, Ryuta; Onoue, Shinji; Ota, Shinya; Nonaka, Hisato; (29 pag.)JP2016/84347; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 170112-66-0, The chemical industry reduces the impact on the environment during synthesis 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, I believe this compound will play a more active role in future production and life.

3,4,5-fluoro-iodobenzene (10.0g, 38.0mmol), bromo difluoroethyl acetate (23.1g, 114mmol) and copper (2.90g, 45.6mmol) and stirred for 3 h with dimethyl sulfoxide solution (40ml) 80 of.Ethyl acetate was added to the reaction mixture, the insoluble matter was separated by filtration.Pour the water filtrate was extracted with ethyl acetate.The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The concentrate was purified by silica gel column chromatography and purified by (elution solvent ethyl acetate / n-hexane = 1/10) to give the title compound as a colorless oil (yield 7.20 g, 75% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trifluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hokko Chemical Industry; Suzuki, Jun; Hiroki, Eisho; Nonaka, Hisato; (15 pag.)JP2016/84346; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

170112-66-0, name is 3,4,5-Trifluoroiodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H2F3I

1 mmol of cp-2-19 was dissolved in 10 ml of anhydrous acetonitrile and 0.05 mmol of Pd (OAc) 2,0.1 mmol of P (O-Tolyl) 3 and 3 mmol of Et3N, followed by addition of 1.5 mmol of 3,4,5-trifluoroiodobenzene and Ar gas for 12 h.After filtration, the filtrate was evaporated to dryness and the dichloromethane was dissolved, washed with water, washed with saturated NaCl and treated with anhydrous MgSO4. The silica gel column (PE: EA 50: 1)To the compound

The synthetic route of 170112-66-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Peking University; Fu, Hongzheng; Chen, Peng; (29 pag.)CN106543032; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com