Category: 165534-79-2

Henry, Kenneth J. Jr. published the artcileDiscovery of a Series of Cyclohexylethylamine-Containing Protein Farnesyltransferase Inhibitors Exhibiting Potent Cellular Activity, Synthetic Route of 165534-79-2, the publication is Journal of Medicinal Chemistry (1999), 42(23), 4844-4852, database is CAplus and MEDLINE.

Synthesis of a library of secondary benzylic amines based on the Sebti-Hamilton type peptidomimetic farnesyltransferase (FTase) inhibitor FTI-276 led to the identification of [(I); R = H] as a potent enzyme inhibitor (IC₅₀ of 8 nM) which lacked the problematic thiol residue which had been a common theme in many of the more important FTase inhibitors reported to date. It has previously been disclosed that addition of o-tolyl substitution to FTase inhibitors of the general description (II) had a salutary effect on both FTase inhibition and inhibition of Ras prenylation in whole cells. Combination of these two observations led us to synthesize [I; R = Me(III)], a potent FTase inhibitor which displayed an IC₅₀ of 0.16 nM for in vitro inhibition of FTase and an EC₅₀ of 190 nM for inhibition of whole cell Ras prenylation. Modification of III by classical medicinal chem. led to the discovery of a series of potent FTase inhibitors, culminating in the identification of (IV) which exhibited an IC₅₀ of 0.20 nM and an EC₅₀ of 4.4 nM. In vivo tests in a nude mouse xenograft model of human pancreatic cancer (MiaPaCa cells) showed that oral dosing of IV gave rise to impressive attenuation of the growth of this aggressive tumor cell line.

Journal of Medicinal Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Synthetic Route of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hu, Yun-Xia published the artcileSynthesis, crystal structures, and photoluminescence of two novel zinc coordination polymers built from 2,2′-(ethyne-1,2-diyl)diterephthalate, Quality Control of 165534-79-2, the publication is Inorganic Chemistry Communications (2012), 173-176, database is CAplus.

Two coordination polymers, [Zn(EDDT)_0.5(H₂O)₂] (1) and [Zn(EDDT)_0.5(BPE)]·xG (2) (EDDT = 2,2′-(ethyne-1,2-diyl)diterephthalate, BPE = 1,2-bi(4-pyridyl)ethane, G = guest mol.), were solvothermally synthesized from the rigid planar linker of EDDT and the coligand of BPE, resp., in which complex 1 displays 2-dimensional [Zn(EDDT)_0.5] coordination layer, and the resulting 3-dimensional supramol. network is formed via interlayer H-bonding interactions, whereas complex 2 exhibits an intriguing microporous framework via the coordination of auxiliary ligand BPE. Both of them show enhanced strong blue luminescence.

Inorganic Chemistry Communications published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Quality Control of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nauroozi, Djawed published the artcileSynthesis and solvent-free polymerisation of vinyl terephthalate for application as an anode material in organic batteries, Related Products of iodides-buliding-blocks, the publication is RSC Advances (2016), 6(112), 111350-111357, database is CAplus.

The synthesis and polymerization of di-Me 2-vinylterephthalate M1 for possible applications as an anode material in organic secondary batteries are reported. M1 exhibits a vinyl group as a polymerisable unit while the carboxylate moieties serve as cation (Li⁺, Na⁺) coordinating sites. The gram-scale synthesis of M1 is described via three different routes in order to evaluate the route with the highest overall yield. Furthermore, different conditions for free radical polymerization are investigated for obtaining polymer P1 with high mol. weights in order to study the impact of immobilizing the carboxylate redox-active centers in a polymer on the charge/discharge cycling stability when used in an organic battery. In order to synthesis suitable materials for battery investigations, P1 was post-functionalised to the corresponding lithium salt P1-Li, which was further electrochem. investigated. Cyclic voltammetry measurements showed for P1-Li redox activity in the range of 0.5-1.2 V vs. Li⁺/Li which assigns it as a candidate for the anode. Under the present exptl. conditions, the galvanostatic measurements of P1-Li exhibited a specific capacity of 64 mA h g^-1. It is further demonstrated that P1-Li shows an improved cycling stability of 83% discharge capacity remaining after 100 cycles compared to the parent monomer (44%).

RSC Advances published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fluch, Ulrike published the artcileUniform distribution of post-synthetic linker exchange in metal-organic frameworks revealed by Rutherford backscattering spectrometry, Category: iodides-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(48), 6516-6519, database is CAplus and MEDLINE.

Rutherford backscattering spectrometry (RBS) has been used for the first time to study post-synthetic linker exchange (PSE) in metal-organic frameworks. RBS is a non-invasive method to quantify the amount of introduced linker, as well as providing a means for depth profiling to identify the preferred localization of the introduced linker. The exchange of benzenedicarboxylate (bdc) by similarly sized 2-iodobenzenedicarboxylate (I-bdc) proceeds considerably slower than migration of I-dbc through the UiO-66 crystal [Zr₆(OH)₄O₄(C₈H₄O₄)₆]. Consequently, the I-bdc is found evenly distributed throughout the UiO-66 samples, even at very short PSE exposure times.

Chemical Communications (Cambridge, United Kingdom) published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bolchi, Cristiano published the artcilePeptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency, HPLC of Formula: 165534-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(22), 6192-6196, database is CAplus and MEDLINE.

2-O-Tolyl or 2-o-anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, resp., are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixteen compounds, resulting from the substitution pattern of benzamide and the configuration of the two stereocenters, seven inhibited FTase activity with potencies in the nanomolar range. They were all 2-oxymethylpyridodioxane ethers and, among them, the four o-tolyl substituted stereoisomers also showed micromolar antiproliferative effect on human aortic smooth muscle cells interfering with Ras farnesylation. The docking anal. enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, HPLC of Formula: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Augeri, David J. published the artcilePotent and Selective Non-Cysteine-Containing Inhibitors of Protein Farnesyltransferase, HPLC of Formula: 165534-79-2, the publication is Journal of Medicinal Chemistry (1998), 41(22), 4288-4300, database is CAplus and MEDLINE.

Potent and selective non-thiol-containing inhibitors of protein farnesyltransferase are described. FTI-276 was transformed into the pyridyl ether analog. The potency of the pyridyl ether was improved by modification of the biphenyl core to that of an o-tolyl substituted biphenyl core. In addition to 0.4 nM in vitro potency, this compound displayed 350 nM potency in whole cells as the parent carboxylic acid. The o-tolyl biphenyl core dramatically and unexpectedly enhanced the potency of other compounds

Journal of Medicinal Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, HPLC of Formula: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fujita, Morifumi published the artcileAsymmetric Synthesis of 4,8-Dihydroxyisochroman-1-one Polyketide Metabolites Using Chiral Hypervalent Iodine(III), Safety of Dimethyl 2-iodoterephthalate, the publication is Organic Letters (2012), 14(5), 1294-1297, database is CAplus and MEDLINE.

Stereoselective oxylactonization of ortho-alkenylbenzoate with chiral hypervalent iodine is applied to the asym. synthesis of 4-oxyisochroman-1-one polyketide metabolites including 4-hydroxymellein (I), a derivative of fusarentin II, monocerin (3), and an epimer III of monocerin.

Organic Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Moreton, Jessica C. published the artcileAn X-ray Photoelectron Spectroscopy Study of Postsynthetic Exchange in UiO-66, Recommanded Product: Dimethyl 2-iodoterephthalate, the publication is Langmuir (2022), 38(4), 1589-1599, database is CAplus and MEDLINE.

Postsynthetic exchange (PSE) is a method that is widely used to change the composition of metal-organic frameworks (MOFs) by replacing connecting linkers or metal nodes after the framework was synthesized. However, few techniques can probe the nature and distribution of exchanged species following PSE. Herein, XPS can be used to compare the relative concentrations of exchanged ligands at the surface and interior regions of MOF particles. Specifically, PSE of iodobenzene dicarboxylate ligands results in a gradient distribution from surface to bulk in UiO-66 nanoparticles that depends on PSE time. XPS also reveals differences between the surface chem. of the PSE product and that of the direct synthesis product.

Langmuir published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Recommanded Product: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Moreton, Jessica C. published the artcileAn X-ray Photoelectron Spectroscopy Study of Postsynthetic Exchange in UiO-66, Recommanded Product: Dimethyl 2-iodoterephthalate, the publication is Langmuir (2022), 38(4), 1589-1599, database is CAplus and MEDLINE.

Postsynthetic exchange (PSE) is a method that is widely used to change the composition of metal-organic frameworks (MOFs) by replacing connecting linkers or metal nodes after the framework was synthesized. However, few techniques can probe the nature and distribution of exchanged species following PSE. Herein, XPS can be used to compare the relative concentrations of exchanged ligands at the surface and interior regions of MOF particles. Specifically, PSE of iodobenzene dicarboxylate ligands results in a gradient distribution from surface to bulk in UiO-66 nanoparticles that depends on PSE time. XPS also reveals differences between the surface chem. of the PSE product and that of the direct synthesis product.

Langmuir published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Recommanded Product: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Steverlynck, Joost published the artcileInfluence of branching on the chiral self-assembly of poly(phenylene ethynylene), Computed Properties of 165534-79-2, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2015), 53(1), 79-84, database is CAplus.

In this contribution, we report the synthesis of chiral all-conjugated branched poly(phenylene ethynylenes) with a controlled amount of branching. Subsequently, the self-assembly of these PPEs is studied by means of UV-vis, fluorescence spectroscopy, and DSC and the influence of branching is investigated. Finally, CD-spectroscopy is used to study the influence of branching and self-assembly on the chiral expression of these polymers. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 79-84.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C20H17FO4S, Computed Properties of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com