Category: 165534-79-2

Schweez, Christopher published the artcileSynthesis and Dynamics of Nanosized Phenylene-Ethynylene-Butadiynylene Rotaxanes and the Role of Shape Persistence, Application In Synthesis of 165534-79-2, the publication is Angewandte Chemie, International Edition (2016), 55(10), 3328-3333, database is CAplus and MEDLINE.

Phenylacetylene-based [2]rotaxanes were synthesized by a covalent-template approach by aminolysis of the corresponding prerotaxanes. The wheel and the bulky stoppers are made of phenylene-ethynylene-butadiynylene macrocycles of the same size. The stoppers are large enough to enable the synthesis and purification of the rotaxane. However, the wheel unthreads from the axle at elevated temperatures The deslipping kinetics and the activation parameters were determined We described theor. the unthreading by state-of-the-art DFT-based mol.-mechanics models and a string method for the simulation of rare events. This approach enabled us to characterize in detail the unthreading mechanism, which involves the folding of the stopper during its passage through the wheel opening, a process that defies intuitive geometrical considerations. The conformational and energetic features of the transition allowed us to infer the mol. residues controlling the disassembly timescale.

Angewandte Chemie, International Edition published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C12H13NO3, Application In Synthesis of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Brian P. published the artcileThe synthesis of an aminohexyl-containing analog of the chromanol leukotriene B₄ receptor antagonist CP-195543: a scaffold for the preparation of derivatized analogs, Safety of Dimethyl 2-iodoterephthalate, the publication is Heterocycles (2000), 53(8), 1713-1724, database is CAplus.

In order to allow the preparation of labeled derivatives of the leukotriene B₄ (LTB₄) antagonist CP-195543 for the study and/or “visualization” of LTB₄ receptors in in vitro and in vivo settings, we have synthesized an aminohexyl-containing analog as a scaffold from which the requisite compounds can be prepared The key reactions in the preparation of the analog include the DAST-mediated introduction of a difluoromethylene group in the presence of an azide and a Suzuki coupling between this highly functionalized benzoate and a chromanol-derived boronic acid. 2-(3S,4R)-(3-Benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoro-7-methanesulfonamidoheptyl)benzoic acid, prepared from the analog by methanesulfonylation and saponification, is a potent LTB₄ receptor antagonist but displays a high degree of non-specific binding.

Heterocycles published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Benoit, Adam R. published the artcileSynthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity, SDS of cas: 165534-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(14), 3014-3017, database is CAplus and MEDLINE.

A series of 9-(alkylamino)acridine derivatives was prepared and evaluated for activity against two strains of methicillin-resistant and one strain of methicillin-sensitive Staphylococcus aureus. Results are presented that show a clear structure activity relationship between the N-alkyl chain length and antibacterial activity with peak MIC₉₉ values of 2-3 μM for alkyl chains ranging from 10 to 14 carbons in length. Although prior work has linked the function of acridine-based compounds to intercalation and topoisomerase inhibition, the present results show that 9-(alkylamino)acridine derivatives likely function as amphiphilic membrane-active disruptors potentially in a similar manner as quaternary ammonium antimicrobial agents. The synthesis of the target compounds was achieved by a reaction (substitution) of 9-(phenoxy)acridine or (4-methyl-1-piperazinyl)(9-phenoxy-3-acridinyl)methanone or 9,10-dihydro-9-oxo-3-acridinecarboxylic acid (amidation) with 1-alkanamine derivatives The title compounds thus formed included N-(alkyl)-9-acridinamine derivatives and (4-methyl-1-piperazinyl)[9-[(alkyl)amino]-3-acridinyl)methanone derivatives and 9,10-dihydro-9-oxo-N-alkyl-3-acridinecarboxamide derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, SDS of cas: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mannancherry, Rajesh published the artcileMolecular dynamic staircases: all-carbon axial chiral “Geländer” structures, Name: Dimethyl 2-iodoterephthalate, the publication is Chemical Science (2018), 9(26), 5758-5766, database is CAplus and MEDLINE.

Herein, the syntheses of two tightly packed all-carbon “Geländer” mols. with axial chirality are described. Motivated by our previous results, we further reduced the bridge length by excluding the heteroatoms. The absolute configuration was determined by comparison of the measured and calculated CD (CD) spectra and the thermodn. stability was determined by dynamic high-performance liquid chromatog. (HPLC) and CD anal. The cyclophanes were fully characterized by CD measurements, X-ray diffraction (XRD) anal., NMR, UV-Vis and high resolution mass spectrometry (HRMS). Our novel all-carbon macrocycle is the most stable Geländer system reported so far.

Chemical Science published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Name: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

McDermott, Todd S. published the artcileProcess research and initial scale-up of ABT-839: A farnesyl-transferase inhibitor, Name: Dimethyl 2-iodoterephthalate, the publication is ACS Symposium Series (2004), 59-69, database is CAplus.

The antitumor compound ABT-839 was synthesized in eight steps from com. available starting materials. The synthesis was carried out with a single purification prior to final salt isolation. The key sequence is an efficient bromination and a novel bis-coupling strategy that transforms the bi-aryl core to the penultimate ester in a single operation with no isolation in 94% yield. After bisulfate salt formation, the product was isolated as a crystalline solid. The synthesis was carried out on kilogram scale and gave an overall yield of 43%.

ACS Symposium Series published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Name: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Renhe published the artcileDirect Vicinal Difunctionalization of Thiophenes Enabled by the Palladium/Norbornene Cooperative Catalysis, Synthetic Route of 165534-79-2, the publication is Journal of the American Chemical Society (2019), 141(48), 18958-18963, database is CAplus and MEDLINE.

Herein a direct vicinal difunctionalization of thiophenes via the palladium/norbornene (Pd/NBE) cooperative catalysis is reported. A series of mono- and disubstituted thiophenes can be difunctionalized site-selectively and regioselectively at the C4 and C5 positions in good yields, enabled by an arsine ligand and a unique amide-based NBE. The synthetic utility has been shown in derivatizations of complex bioactive compounds and an open-flask gram-scale preparation Preliminary results have been obtained in the difunctionalization of furans and a direct C4-selective arylation of 2-substituted thiophenes.

Journal of the American Chemical Society published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Synthetic Route of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Peng, Ye-Dong published the artcileFerrocene-isocoumarin conjugated molecules: synthesis, structural characterization, electronic properties, and DFT-TDDFT computational study, Related Products of iodides-buliding-blocks, the publication is Dalton Transactions (2015), 44(32), 14465-14474, database is CAplus and MEDLINE.

Two ferrocene-isocoumarin conjugated mols., Me 3-ferrocenyl-1-oxo-1H-isochromene-6-carboxylate (Fc-Icm) and 3,8-bisferrocenylpyrano[3,4-g]isochromene-1,6-dione (BFc–PIcm), were synthesized through the acid-prompted regioselective oxidative cyclization from di-Me 2-(ferrocenylethynyl)terephthalate (Fc-TP) and di-Me 2,5-bis(ferrocenylethynyl)terephthalate (BFc-TP), resp. Single-crystal x-ray diffraction, together with the d. functional theory (DFT) calculations, shows that the ferrocene-isocoumarin conjugated compounds display better coplanarity than the corresponding ferrocenylethynyl terephthalates. All the compounds exhibit characteristic MLCT, ICT and π-π^* transitions in the UV-visible range in solution, and Fc-Icm and BFc-PIcm show higher oscillator strength of the absorption than Fc-TP and BFc-TP, which are verified by time-dependent DFT (TDDFT) theor. calculations The electrochem. properties were studied by cyclic voltammetry (CV), which are also in accord with the theor. calculations

Dalton Transactions published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Roesch, Kevin R. published the artcileSynthesis of Isoquinolines and Pyridines by the Palladium-Catalyzed Iminoannulation of Internal Alkynes, Application In Synthesis of 165534-79-2, the publication is Journal of Organic Chemistry (2001), 66(24), 8042-8051, database is CAplus and MEDLINE.

A wide variety of substituted isoquinoline, tetrahydroisoquinoline, 5,6-dihydrobenz[f]isoquinoline, pyrindine, and pyridine heterocycles have been prepared in good to excellent yields via annulation of internal acetylenes with the tert-butylimines of o-iodobenzaldehydes and 3-halo-2-alkenals in the presence of a palladium catalyst. The best results are obtained by employing 5 mol % of Pd(OAc)₂, an excess of the alkyne, 1 equiv of Na₂CO₃ as a base, and 10 mol % of PPh₃ in DMF as the solvent. This annulation methodol. is particularly effective for aryl- or alkenyl-substituted alkynes. When electron-rich imines are employed, this chem. can be extended to alkyl-substituted alkynes. Trimethylsilyl-substituted alkynes also undergo this annulation process to afford monosubstituted heterocyclic products absent the silyl group.

Journal of Organic Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Application In Synthesis of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ding, Qiuping published the artcileLigand-Enabled meta-Selective C-H Arylation of Nosyl-Protected Phenethylamines, Benzylamines, and 2-Aryl Anilines, Safety of Dimethyl 2-iodoterephthalate, the publication is Journal of the American Chemical Society (2017), 139(1), 417-425, database is CAplus and MEDLINE.

A Pd-catalyzed, meta-selective C-H arylation of nosyl-protected phenethylamines and benzylamines is disclosed using a combination of norbornene and pyridine-based ligands. Subjecting nosyl protected 2-aryl anilines to this protocol led to meta-C-H arylation at the remote aryl ring. A diverse range of aryl iodides are tolerated in this reaction, along with select heteroaryl iodides. Select aryl bromides bearing ortho-coordinating groups can also be utilized as effective coupling partners in this reaction. The use of pyridine ligands has allowed the palladium loading to be reduced to 2.5 mol %. Furthermore, a catalytic amount of 2-norbornene (20 mol %) to mediate this meta-C-H activation process is demonstrated for the first time. Utilization of a common protecting group as the directing group for meta-C-H activation of amines is an important feature of this reaction in terms of practical applications.

Journal of the American Chemical Society published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dong, Zhe published the artcileSimple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis, Quality Control of 165534-79-2, the publication is Journal of the American Chemical Society (2015), 137(18), 5887-5890, database is CAplus and MEDLINE.

Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by com. available AsPh₃ as the ligand and a unique “acetate cocktail”. Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work.

Journal of the American Chemical Society published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Quality Control of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com