Category: 162358-07-8

Reference of 162358-07-8, These common heterocyclic compound, 162358-07-8, name is 1-(2-Iodoethyl)-4-octylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2: Preparation of diethyl 2-acetamido-2-(4-octylphenyl) ethyl malonate (III) Diethyl acetamidomalonate (59.86 gms), cesium carbonate (89.67gm, 0.27moles) and tetrabutyl ammonium iodide (21.42gms; 0.05moles) in DMSO (400ml) were stirred at 25 to 30C. 2-(4-Octylphenyl)ethyl iodide (IV) (lOOgms, 0.29moles) was gradually added to the reaction mixture under nitrogen atmosphere and stirred at 80 to 85C till completion of reaction. The reaction mixture was filtered,, mixed with 1% potassium hydrogen sulfate solution, cooled to 0 to 5 C and filtered. The obtained solid was mixed with ethyl acetate and water was added to the mixture. Separation and concentration of the organic layer provided a residue containing 2-acetamido-2-(4- octylphenyl)ethyl malonate (III) which was crystallized from hexane.Yield: 110.8gms (88%);Purity: 99.9%

The synthetic route of 162358-07-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EMCURE PHARMACEUTICALS LIMITED; GURJAR MUKUND KESHAV; TRIPATHY NARENDRA KUMAR; NEELAKANDAN KALIAPERUMAL; PANCHABHAI PRASAD PANDURANG; SRINIVAS NANDALA; BALASUBRAMANIAN PRABHAKARAN; BUCHUDE SANDIP BAJABA; MUGALE BALAJI RAM; AHIRRAO PRAVIN PRABHAKAR; MEHTA SAMIT SATISH; WO2015/92809; (2015); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 162358-07-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 162358-07-8, name is 1-(2-Iodoethyl)-4-octylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(1) Ethyl 2-Ethoxycarbonyl-4-(4-octylphenyl)butyrate Sodium (2.67 g) was dissolved in absolute ethanol (100 ml) and diethyl malonate (18.6 g) was dropwise added thereto at 27-30 C. for 3 minutes. The mixture was stirred at 40 C. for 40 minutes and 2-(4-octylphenyl)ethyl iodide (40 g) was dropwise added to the reaction mixture at 44-45 C. over 10 minutes. The mixture was refluxed at 50 C. for 1 hour and stirred under heating for 1.5 hours. The reaction mixture was cooled and the solvent was distilled away under reduced pressure. Water was added thereto and extracted with ethyl acetate. The extract was washed with water and dried over magnesium sulfate. The solvent was distilled away under reduced pressure and the residue obtained was subjected to silica gel column chromatography to give the subject compound (28.8 g). IR: 2920, 2850, 1745, 1725, 1240, 1140, 1040 cm-1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2-Iodoethyl)-4-octylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; Taito Co., Ltd.; US5604229; (1997); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 162358-07-8, A common heterocyclic compound, 162358-07-8, name is 1-(2-Iodoethyl)-4-octylbenzene, molecular formula is C16H25I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 16 Production of diethyl acetamido-2-(4-octylphenyl)ethylmalonate (8) [Step (H)] To a solution of diethyl acetamidomalonate (277 g) and sodium ethylate (86.6 g) in anhydrous ethanol (850 ml) is added a solution of 2-(4-octylphenyl)ethyl iodide (7) (146 g) in anhydrous tetrahydrofuran (533 ml), and the mixture is refluxed under heating for 6 hr. The reaction mixture is concentrated and partitioned between water and hexane, and the hexane layer is washed three times with water. The obtained hexane layer is dried over anhydrous magnesium sulfate and concentrated. The residue is recrystallized from hexane to give the title compound (8) as colorless crystals. The resulting Compound (8) has the same physico-chemical characteristics as indicated in Example 7.

The synthetic route of 162358-07-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Abel, Stephan; Fujita, Tetsuro; Hirose, Ryoji; Jordine, Guido; Mishina, Tadashi; US2002/72635; (2002); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 162358-07-8 as follows. 162358-07-8

(2) Diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate To a suspension of sodium hydride (6 g) in dimethylformamide (100 ml), a solution of ethyl acetamidomalonate (33 g) in dimethylformamide (100 ml) was added under ice-cooling and the mixture was stirred at room temperature for 2 hours. A solution of 2-(4-octylphenyl)ethyl iodide (37 g) in dimethyl-formamide (100 ml) was added to the mixture under ice-cooling. The mixture was stirred for 2 hours at the same temperature and left standing overnight. The resultant mixture was poured into water and extracted with ethyl acetate. The extract was washed with a saturated brine and dried over magnesium sulfate. The solvent was distilled away under reduced pressure and the residue was purified by silica gel chromatography (eluent; hexane-ethyl acetate=3:1) to give the subject compound (25 g). Rf value: 0.40 (hexane-ethyl acetate=2:1) 1 H-NMR(400 MHz, CDCl:3) delta: 0.88 (3H, t, J=8 Hz), 1.20-1.30 (10H, m), 1.24 (6H, t, J=8 Hz), 1.50-1.62 (2H, m), 1.97 (3H, s), 2.45 (2H, dd, J=12, 8 Hz), 2.54 (2H, t, J=8 Hz), 2.68 (2H, dd, J=12, 8 Hz), 4.14-4.26 (4H, m), 6.75 (1H, s), 7.05 (2H, d, J=8 Hz), 7.08 (2H, d, J=8 Hz)

According to the analysis of related databases, 162358-07-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5948820; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com