Category: 161370-66-7

Watanabe, Daisuke published the artcileSynthesis of desmosine-d₄: Improvement of isotopic purity by D-H exchange of amino groups, Computed Properties of 161370-66-7, the publication is Tetrahedron Letters (2017), 58(12), 1194-1197, database is CAplus.

Desmosine is a crosslinking pyridinium amino acid of elastin, which is a useful biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD) by LC-MS/MS anal. We previously reported a synthesis of desmosine-d₄, which is useful as an internal standard for quant. LC-MS/MS anal. of desmosines, by deuterogenation of an alkyne group; however, the isotopic purity of the desmosine-d₄ was only ca. 50%. The present report describes a new synthesis of desmosine-d₄ that improves the isotopic purity to ca. 90% by exchanging the protons of the amino groups to deuterium using deuterogenation.

Tetrahedron Letters published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C12H15BF2O2, Computed Properties of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Amino, Yusuke published the artcileSynthesis and evaluation of L-cystathionine as a standard for amino acid analysis, Safety of (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, the publication is Bioscience, Biotechnology, and Biochemistry (2017), 81(1), 95-101, database is CAplus and MEDLINE.

L-Cystathionine is a key nonprotein amino acid related to metabolic conditions. The quant. determination of L-cystathionine in physiol. fluids by amino acid anal. is important for clin. diagnosis; however, certified reference material for L-cystathionine with satisfactory purity, content, and quantity has been unavailable until recently. Consequently, a practical and simple method for the preparation of L-cystathionine was examined, which involves thioalkylation of N-tert-butoxycarbonyl-L-cysteine tert-Bu ester, derived from L-cystine, with (2S)-2-(tert-butoxycarbonyl)amino-4-iodobutanoic acid tert-Bu ester, derived from L-aspartic acid, to obtain L-cystathionine with protecting groups, followed by single-step deprotection under mild conditions. This method produces L-cystathionine in high purity (99.4%) and having sufficient percentage content according to amino acid anal., which could be used as a standard for the amino acid anal. of physiol. fluids.

Bioscience, Biotechnology, and Biochemistry published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Safety of (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gleede, Tassilo published the artcileInvestigation of S_N2 [¹¹C]cyanation for base-sensitive substrates: an improved radiosynthesis of L-[5-¹¹C]-glutamine, Computed Properties of 161370-66-7, the publication is Amino Acids (2015), 47(3), 525-533, database is CAplus and MEDLINE.

Carbon-11 (β⁺ emitter, t_1/2 = 20.4 min) radiolabeled L-glutamine is a potentially useful mol. imaging agent that can be utilized with positron emission tomog. for both human oncol. diagnosis and plant imaging research. Based upon a previously reported [¹¹C]cyanide end-capping labeling method, a systematic investigation of nucleophilic cyanation reactions and acidic hydrolysis reaction parameters, including base, metal ion source, phase transfer catalyst, solvent, reaction temperature and reaction time, was conducted. The result was a milder, more reliable, two-step method which provides L-[5-¹¹C]-glutamine with a radiochem. yield of 63.8 ± 8.7% (range from 51 to 74%, n = 10) with >90% radiochem. purity and >90% enantiomeric purity. The total synthesis time was 40-50 min from the end of bombardment. In addition, an Fmoc derivatization method was developed to measure the specific activity of this radiotracer.

Amino Acids published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Computed Properties of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Zhen-Qi published the artcileCopper-Catalyzed/Promoted Cross-coupling of gem-Diborylalkanes with Nonactivated Primary Alkyl Halides: An Alternative Route to Alkylboronic Esters, Synthetic Route of 161370-66-7, the publication is Organic Letters (2014), 16(24), 6342-6345, database is CAplus and MEDLINE.

The first copper-catalyzed/promoted sp³-C Suzuki-Miyaura coupling reaction of gem-diborylalkanes with nonactivated electrophilic reagents is reported. Not only 1,1-diborylalkanes but also some other gem-diborylalkanes can be coupled with nonactivated primary alkyl halides, offering a new method for sp³C-sp³C bond formation and, simultaneously, providing a new strategy for the synthesis of alkylboronic esters.

Organic Letters published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C6H8BNO3, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xi published the artcileExpedient synthesis of chiral α-amino acids through nickel-catalyzed reductive cross-coupling, Synthetic Route of 161370-66-7, the publication is Chemistry – A European Journal (2014), 20(47), 15339-15343, database is CAplus and MEDLINE.

A novel method for the synthesis of non-natural L– and D-amino acids by a Ni-catalyzed reductive cross-coupling reaction is described. This strategy enables the racemization-free cross-coupling of serine/homoserine-derived iodides with aryl/acyl/alkyl halides. It provides convenient access to varieties of enantiopure and functionalized amino acids, which are important building blocks in bioactive compounds and pharmaceuticals.

Chemistry – A European Journal published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Siebum, Arjan H. G. published the artcileAccess to any site-directed isotopomer of methionine, selenomethionine, cysteine, and selenocysteine – use of simple, efficient modular synthetic reaction schemes for isotope incorporation, Quality Control of 161370-66-7, the publication is European Journal of Organic Chemistry (2004), 2905-2913, database is CAplus.

Simple modular reaction schemes that allow access to any isotopomer of protected serine and homoserine have been worked out. These systems could be simply converted into cysteine, selenocysteine, homocysteine, homoselenocysteine, the essential amino acid methionine, and selenomethionine by Mitsunobu chem. These sulfur- and selenium-containing amino acids fulfil many essential roles in the living organism. In addition, homoserine could be converted in a few steps into optically active L-vinylglycine. As well as the stable isotopes ¹³C, ¹⁵N, ¹⁷O, and ¹⁸O, the radioactive isotopes of sulfur, selenium and carbon can also be easily introduced in a site-directed fashion. In view of the wide scope of the Mitsunobu reaction, we feel that many more important systems with the carbon skeleton of serine and homoserine should be preparable through this basic chem. in any site-directed isotopically labeled form.

European Journal of Organic Chemistry published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C8H9NOS, Quality Control of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xi published the artcilePractical carbon-carbon bond formation from olefins through nickel-catalyzed reductive olefin hydrocarbonation, HPLC of Formula: 161370-66-7, the publication is Nature Communications (2016), 11129pp., database is CAplus and MEDLINE.

A general process for the intermol. reductive coupling of unactivated olefins with alkyl or aryl electrophiles under the promotion of a simple nickel catalyst system was reported. This new reaction presented a conceptually unique and practical strategy for the construction of C(sp²)-C(sp³) and C(sp³)-C(sp³) bonds without using any organometallic reagent. The reductive olefin hydrocarbonation also exhibited excellent compatibility with varieties of synthetically important functional groups and therefore, provided a straightforward approach for modification of complex organic mols. containing olefin groups.

Nature Communications published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, HPLC of Formula: 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohwada, Jun published the artcileSynthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin, Formula: C13H24INO4, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(8), 1703-5, database is CAplus and MEDLINE.

A new antifungal substance, azoxybacilin (I; R = OH), an unusual amino acid with an azoxy moiety and its derivatives were prepared from Boc-Asp-OCMe₃ utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative I (R = OCH₂Ph), Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.

Chemical & Pharmaceutical Bulletin published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Formula: C13H24INO4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Takaishi, Tomohiro published the artcileMultigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives, SDS of cas: 161370-66-7, the publication is Heterocycles (2018), 96(12), 2126-2134, database is CAplus.

Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatog. and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.

Heterocycles published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C8H15NO, SDS of cas: 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yan published the artcileCobalt-catalysed enantioselective C(sp³)-C(sp³) coupling, Synthetic Route of 161370-66-7, the publication is Nature Catalysis (2021), 4(10), 901-911, database is CAplus.

Enantioselective C(sp³)-C(sp³) coupling substantially impacts organic synthesis but remains challenging. Cobalt has played an important role in the development of homogeneous organometallic catalysis, but there are few examples of its use in asym. cross-coupling. Here, a cobalt-catalyzed enantioselective C(sp³)-C(sp³) coupling reaction, namely, alkene hydroalkylation, to access chiral fluoroalkanes was reported. This reaction represents a catalyst-controlled enantioselective coupling mode in which a tailor-made auxiliary is unnecessary; via this reaction, an aliphatic C-F stereogenic center can be introduced at the desired position in an alkyl chain.

Nature Catalysis published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com