Continuously updated synthesis method about 160976-02-3

According to the analysis of related databases, 160976-02-3, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 160976-02-3 as follows. Safety of 5-Bromo-1,3-difluoro-2-iodobenzene

(5-a) Synthesis of compound 4-bromo-2,6-difluoro-4′-(trans-4-pentylcyclohexyl)biphenyl represented by formula: First, 50 ml of ethanol containing 5.61 g of 4-(trans-4-pentylcyclohexyl)phenylboronic acid dissolved therein, 50 ml of benzene containing 5.0 g of 4-bromo-2,6-difluoro-1-iodobenzene dissolved therein, 15.7 ml of a sodium carbonate aqueous solution with a concentration of 2.0 mol/l, and 0.45 g of tetrakis(triphenylphosphine)palladium(0) were put in an argon-replaced 200 ml flask, and stirred under reflux for 48 hours.. After the reaction, water and ether were added to the reaction solution for extraction.. The resultant ether layer was washed with a saturated brine and dried with sodium sulfate.. The solvent was then distilled off.. The residue was purified by silica gel column chromatography (eluent:hexane) and recrystallized from acetone, to obtain 2.58 g (Y: 39.1%) of 4-bromo-2,6-difluoro-4′-(trans-4-pentylcyclohexyl)biphenyl.. The purity of the resultant compound was 100.0% as measured by GC. (5-b) Synthesis of polymerizable compound 2,6-difluoro-4′-(trans-4-pentylcyclohexyl)-4-vinylbiphenyl represented by formula (E) above First, 2.58 g of 4-bromo-2,6-difluoro-4′-(trans-4-pentylcyclohexyl)biphenyl obtained from the synthesis (5-a) above, 2.33 g of tributylvinyltin, 0.18 g of tetrakis(triphenylphosphine)palladium(0), 0.008 g of p-methoxyphenol, and 50 ml of anhydrous toluene were put in an argon-replaced 300 ml flask, and stirred under reflux for nine hours..

According to the analysis of related databases, 160976-02-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sharp Kabushiki Kaisha; Kanto Kagaku Kabushiki Kaisha; US6388146; (2002); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Continuously updated synthesis method about C6H2BrF2I

According to the analysis of related databases, 160976-02-3, the application of this compound in the production field has become more and more popular.

Reference of 160976-02-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 160976-02-3 as follows.

To a solution of 5-bromo-1,3-difluoro-2-iodobenzene (10.0 g, 0.048 mol) in N-methyl pyrrolidone (50 mL) was added CuCN (5.2 g, 0.057 mol). The reaction mixture was heated toreflux for 1.5 h. The reaction mixture was added EDTA, water and extracted with EtOAc. The organic layers were dried over Na2504 and concentrated to afford 1.6 g of title compound.

According to the analysis of related databases, 160976-02-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; KADAM, Sheetal R; (303 pag.)WO2016/55947; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Brief introduction of 5-Bromo-1,3-difluoro-2-iodobenzene

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 160976-02-3, its application will become more common.

Some common heterocyclic compound, 160976-02-3, name is 5-Bromo-1,3-difluoro-2-iodobenzene, molecular formula is C6H2BrF2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H2BrF2I

A 2 M aqueous Na2CO3 solution (1 .51 mL) is added to a mixture of 5-bromo-1 ,3- difluoro-2-iodo-benzene (1 .00 g) and 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)- 2-triisopropylsilanyl-oxazole (1 .87 g) in 1 ,4-dioxane (9 mL) and methanol (3 mL). The mixture is sparged with argon and [1 ,1 ‘-bis(diphenylphosphino)-ferrocene]dichloro- palladium dichloromethane complex (380 mg) is added. The resulting mixture is stirred at 80C overnight. Since the conversion is not complete, the same amounts of 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole, 2 M aqueous Na2CO3 solution, and catalyst are added and the mixture is again stirred overnight at 80C. The triisopropylsilyl protecting group is cleaved under these conditions. After cooling to room temperature, ethyl acetate and water are added. The aqueous phase is extracted with ethyl acetate and the combined organic phases are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 1 :0? 1 :1 ) to afford the title compound. LC (method 4): tR = 1 .18 min; Mass spectrum (ESI+): m/z = 260/262 (Br) [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 160976-02-3, its application will become more common.

Sources of common compounds: 160976-02-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,3-difluoro-2-iodobenzene, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 160976-02-3, The chemical industry reduces the impact on the environment during synthesis 160976-02-3, name is 5-Bromo-1,3-difluoro-2-iodobenzene, I believe this compound will play a more active role in future production and life.

General procedure: A Schlenk tube was dried using heat gun under reduced pressure and filled with argon. The tube was charged with TPPO (69.5mg, 0.25mmol) and then the tube was evacuated and refilled with argon (¡Á3). To the tube were added THF (1mL), Me2Zn (0.6mL, 0.6mmol, 1.0M solution in hexane), and fluoroarene 1 (0.75mmol) at room temperature and then the tube was immersed in an oil bath. The reaction mixture was gradually warmed to 75C and stirred for 3h. The mixture was cooled to room temperature and allylic bromide (0.5mmol) was added. The resultant mixture was warmed to 75C and stirred for 16h. The reaction mixture was quenched with saturated aqNH4Cl solution followed by extraction with Et2O (¡Á3). Combined organic layer was washed with brine (¡Á1), dried over Na2SO4, and filtered. Volatiles were removed under reduced pressure and the residue was purified by flash column chromatography on silica gel to afford analytically pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,3-difluoro-2-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kurauchi, Daisuke; Hirano, Keiichi; Kato, Hisano; Saito, Tatsuo; Miyamoto, Kazunori; Uchiyama, Masanobu; Tetrahedron; vol. 71; 35; (2015); p. 5849 – 5857;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The important role of 160976-02-3

The synthetic route of 160976-02-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 160976-02-3, A common heterocyclic compound, 160976-02-3, name is 5-Bromo-1,3-difluoro-2-iodobenzene, molecular formula is C6H2BrF2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under a nitrogen atmosphere, to a three-necked flask equipped with a reflux condenser were added 2,6-difluoro-4-bromoiodobenzene (13.3g, 41.67mmol),9-methyl-9H-carbazole-4-ol (18g, 91.67mmol), potassium carbonate (23g, 166.68mmol) and 200mL N-methylpyrrolidone (NMP), and heated to reflux for 6h.After the reaction, the system was cooled to room temperature. After adding a large amount of water, a white precipitate is formed, which is collected by suction filtration. The precipitate was washed sequentially with water and methanol (50% (V / V)).Finally, the obtained filter cake was dissolved in an appropriate amount of dichloromethane and further purified by column chromatography (mobile phase: petroleum ether: dichloromethane = 3: 1 (V / V)),23g of white solid was obtained with 82% yield.

The synthetic route of 160976-02-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Suzhou Jiuxian New Materials Co., Ltd.; Cui Linsong; Liu Xiangyang; Zhang Yexin; Chen Hua; (56 pag.)CN110981899; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 160976-02-3

The synthetic route of 5-Bromo-1,3-difluoro-2-iodobenzene has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 160976-02-3, name is 5-Bromo-1,3-difluoro-2-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H2BrF2I

In a nitrogen atmosphere, add 2.6-difluoro-p-bromoiodobenzene (0.32 g, 1.01 mmol),o-iodophenol (0.88g, 4.00mmol) and potassium carbonate (0.552mg, 4.00mmol),Then 15 mL of NMP (N-methylpyrrolidone) was added, and the reaction was carried out at 135 C for 12 hours;After the reaction was completed, it was filtered and washed three times with petroleum ether. The organic solutions were combined and concentrated;The crude product was purified with a silica gel column, the eluent was petroleum ether, and the final product was 0.31 g of a white solid with a yield of 43%;

The synthetic route of 5-Bromo-1,3-difluoro-2-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Jiaotong University; Zhou Guijiang; Song Dongdong; Yang Xiaolong; Zhang Yindi; (21 pag.)CN110818738; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com