Category: 15854-87-2

Tamizharasan, Natarajan; Hallur, Gurulingappa; Suresh, Palaniswamy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Palladium-Catalyzed Direct α-Arylation of Indane-1,3-dione to 2-Substituted Indene-1,3-diones》.Product Details of 15854-87-2 The article contains the following contents:

A straightforward and feasible palladium-catalyzed direct α-arylation of indane-1,3-dione to 2-substituted aryl/heteroaryl indene-1,3-diones such as I [R1 = Ph, 3-FC6H4, 2,3-di-ClC6H3, etc.; R2 = H, 5-OMe] using aryl triflates/iodides was disclosed for the first time. Optimization of reaction conditions identified tBu-XPhos as a preferred ligand for the bis(acetonitrile)dichloropalladium(II) catalyst. A broad spectrum of aryl iodides and aryl triflates containing electron-donating, electron-withdrawing, and sterically hindered substituents gave an excellent yield for the quick access α-arylated 1,3-diones library I.4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2) was used in this study.

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Gravatt, Christopher S.; Johannes, Jeffrey W.; King, Eric R.; Ghosh, Avipsa published an article in Journal of Organic Chemistry. The title of the article was 《Photoredox-Mediated, Nickel-Catalyzed Trifluoromethylthiolation of Aryl and Heteroaryl Iodides》.Reference of 4-Iodopyridine The author mentioned the following in the article:

Herein, a method employing a bench-stable Ni(II) salt and an iridium photocatalyst that was mediated the trifluoromethylthiolation of a wide range of electronically diverse aryl and heteroaryl iodides, likely via a Ni(I)/Ni(III) catalytic cycle was reported. The reaction was broad functional group tolerance and potential for application in medicinal chem., as demonstrated by a late-stage functionalization approach to access (racemic)-Monepantel. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Reference of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sabourin, Axel; Dufour, Jeremy; Vors, Jean-Pierre; Bernier, David; Montchamp, Jean-Luc published an article in European Journal of Organic Chemistry. The title of the article was 《Synthesis of Carbon- and Nitrogen-Substituted 5- and 6-Membered Benzophostams》.Quality Control of 4-Iodopyridine The author mentioned the following in the article:

Previously, the synthesis of the novel 6-membered and a series of P-substituted 5-membered benzophostams was accomplished. Here, the synthesis of N- and C-substituted benzophostams is presented. For N-substitution, alkylation was accomplished using the heterocycle, LiHMDS and an alkyl halide, or alternatively by copper-catalyzed cyclization of the N-alkyl phosphonamide. N-Arylation could similarly be accomplished on the preformed heterocycle or on the phosphonamide precursor via copper-catalyzed cross-coupling. Dimethylation at the benzylic position could be conducted with LiHMDS and Me iodide. However, due to the significant cost of LiHMDS, a much less expensive and more efficient alternative approach was developed relying on a palladium-catalyzed reductive Heck reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Quality Control of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Roemer, Max; Gillespie, Angus; Jago, David; Costa-Milan, David; Alqahtani, Jehan; Hurtado-Gallego, Juan; Sadeghi, Hatef; Lambert, Colin J.; Spackman, Peter R.; Sobolev, Alexandre N.; Skelton, Brian W.; Grosjean, Arnaud; Walkey, Mark; Kampmann, Sven; Vezzoli, Andrea; Simpson, Peter V.; Massi, Massimiliano; Planje, Inco; Rubio-Bollinger, Gabino; Agrait, Nicolas; Higgins, Simon J.; Sangtarash, Sara; Piggott, Matthew J.; Nichols, Richard J.; Koutsantonis, George A. published an article in Journal of the American Chemical Society. The title of the article was 《2,7- and 4,9-Dialkynyldihydropyrene Molecular Switches: Syntheses, Properties, and Charge Transport in Single-Molecule Junctions》.SDS of cas: 15854-87-2 The author mentioned the following in the article:

This paper described the syntheses of several functionalized dihydropyrene (DHP) mol. switches with different substitution patterns. Regioselective nucleophilic alkylation of a 5-substituted di-Me isophthalate allowed the development of a workable synthetic protocol for the preparation of 2,7-alkyne-functionalized DHPs. Synthesis of DHPs with surface-anchoring groups in the 2,7- and 4,9-positions was described. The mol. structures of several intermediates and DHPs were elucidated by X-ray single-crystal diffraction. Mol. properties and switching capabilities of both types of DHPs were assessed by light irradiation experiments, spectroelectrochem., and cyclic voltammetry. Spectroelectrochem., in combination with d. functional theory (DFT) calculations, shows reversible electrochem. switching from the DHP forms to the cyclophanediene (CPD) forms. Charge-transport behavior was assessed in single-mol. scanning tunneling microscope (STM) break junctions, combined with d. functional theory-based quantum transport calculations All DHPs with surface-contacting groups form stable mol. junctions. Experiments showed that the mol. conductance depends on the substitution pattern of the DHP motif. The conductance was found to decrease with increasing applied bias. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2SDS of cas: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 4-IodopyridineIn 2021 ,《Multitasking with Chemical Fuel: Dissipative Formation of a Pseudorotaxane Rotor from Five Distinct Components》 appeared in Journal of the American Chemical Society. The author of the article were Ghosh, Amit; Paul, Indrajit; Schmittel, Michael. The article conveys some information:

A 3-fold completive self-sorted library of dynamic motifs was integrated into the design of the pseudorotaxane-based rotor [Zn(2·H+)(3)(4)]2+ operating at k298 = 15.4 kHz. The rotational motion in the five-component device is based on association/dissociation of the pyridyl head of the pseudorotaxane rotator arm between two zinc(II) porphyrin stations. Addition of TFA or 2-cyano-2-phenylpropanoic acid as a chem. fuel to a zinc release system and the loose rotor components 2-4 enabled the liberated zinc(II) ions and protons to act in unison, setting up the rotor through the formation of a heteroleptic zinc complex and a pseudorotaxane linkage. With chem. fuel, the dissipative system was reproducibly pulsed three times without a problem. Due to the double role of the fuel acid, two kinetically distinct processes played a role in both the out-of-equilibrium assembly and disassembly of the rotor, highlighting the complex issues in multitasking of chem. fuels. In addition to this study using 4-Iodopyridine, there are many other studies that have used 4-Iodopyridine(cas: 15854-87-2Recommanded Product: 4-Iodopyridine) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Recommanded Product: 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Name: 4-IodopyridineIn 2019 ,《Influence of Donor-Substituents on Triphenylamine Chromophores Bearing Pyridine Fragments》 appeared in European Journal of Organic Chemistry. The author of the article were Tydlitat, Jiri; Feckova, Michaela; le Poul, Pascal; Pytela, Oldrich; Klikar, Milan; Rodriguez-Lopez, Julian; Robin-le Guen, Francoise; Achelle, Sylvain. The article conveys some information:

Efficient synthetic routes that combine different palladium-catalyzed cross-coupling reactions were developed for the preparation of a new family of push-pull derivatives in which pyridine was used as the acceptor group and different para-substituted diphenylamines as the donor groups. All compounds showed absorption in the UV/visible region and blue-green emission with high quantum yields. Significant red shifts were observed in the absorption and fluorescence emission maxima on increasing the electron-donating ability of the substituents or on incorporating a π-conjugated linker. This finding can be explained on the basis of enhanced intramol. charge transfer (ICT). Strong emission solvatochromism confirmed the formation of an intramol. charge-separated emitting state. The HOMO-LUMO energy gaps were estimated by exptl. electrochem. measurements and the results were interpreted with the aid of DFT calculations The thermal behavior of all materials also was studied by DSC. In the experimental materials used by the author, we found 4-Iodopyridine(cas: 15854-87-2Name: 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Name: 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C5H4INIn 2019 ,《Dynamic Open Coordination Cage from Nonsymmetrical Imidazole-Pyridine Ditopic Ligands for Turn-On/Off Anion Binding》 appeared in Angewandte Chemie, International Edition. The author of the article were Ogata, Daiji; Yuasa, Junpei. The article conveys some information:

This work demonstrates a new nonconventional ligand design, imidazole/pyridine-based nonsym. ditopic ligands (1 and 1S), to construct a dynamic open coordination cage from nonsym. building blocks. Upon complex formation with Pd2+ at a 1:4 molar ratio, 1 and 1S initially form mononuclear PdL4 complexes (Pd2+(1)4 and Pd2+(1S)4) without formation of a cage. The PdL4 complexes undergo a stoichiometrically controlled structural transition to Pd2L4 open cages ((Pd2+)2(1)4 and (Pd2+)2(1S)4) capable of anion binding, leading to turn-on anion binding. The structural transitions between the Pd2L4 open cage and the PdL4 complex are reversible. Thus, stoichiometric addition (2 equiv) of free 1S to the (Pd2+)2(1S)4 open cage holding a guest anion ((Pd2+)2(1S)4·G-) enables the structural transition to the Pd2+(1S)4 complex, which does not have a cage and thus causes the release of the guest anion (Pd2+(1S)4+G-). In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Goswami, Abir; Paululat, Thomas; Schmittel, Michael. Product Details of 15854-87-2. The article was titled 《Switching Dual Catalysis without Molecular Switch: Using A Multicomponent Information System for Reversible Reconfiguration of Catalytic Machinery》. The information in the text is summarized as follows:

Different from the current paradigms of chem., a switchable catalytic system is presented that does not rely on a mol. switch in different toggling states but on a smart seven-component mixture that manages the reversible ON/OFF regulation of two catalytic processes. Hereunto, the workflow of two multicomponent rotary catalytic machineries was interlinked by the simultaneous shuffling of two components (metal and ligand) requiring perfect signaling in a 13-component system (see Movie 1). This network underwent reversible switching over three cycles as demonstrated by 1H NMR, UV-visible, and fluorescence spectroscopies and electrospray ionization mass spectrometry. Addition and removal of zinc(II) ions trigger three distinct events in parallel: the (i) mutually dependent self-assembly of three-component nanorotors and two-component reservoirs by resorting components, (ii) toggling between vastly different rotational exchange rates in the self-assembled rotors that directly affect catalysis, and (iii) toggling between two diverse catalytic reactions in a fully reproducible manner. Because of this information system, the concentrations of free aza-crown ether 7 and its complex with copper(I), i.e., [Cu(7)]+, which represent the effective catalysts, are up- and downregulated in a manner to alternately switch ON/OFF a catalytic conjugate addition and a click reaction. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Visseq, Alexia; Descheemaeker, Amelie; Herault, Karine; Giraud, Francis; Abrunhosa-Thomas, Isabelle; Artola, Alain; Anizon, Fabrice; Dallel, Radhouane; Moreau, Pascale published an article in 2021. The article was titled 《Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia》, and you may find the article in European Journal of Medicinal Chemistry.Synthetic Route of C5H4IN The information in the text is summarized as follows:

Mech. allodynia, a painful sensation caused by innocuous touch, is a major chronic pain symptom, which often remains without an effective treatment. There is thus a need for new anti-allodynic treatments based on new drug classes. We recently synthesized new 3,5-disubstituted pyridin-2(1H)-one derivatives By substituting the pyridinone at the 3-position by various aryl/heteroaryl moieties and at the 5-position by a phenylamino group, we discovered that some derivatives exhibited a strong anti-allodynic potency in rats. Here, we report that varying the substitution of the pyridinone 5-position, the 3-position being substituted by an indol-4-yl moiety, further improves such anti-allodynic potency. Compared with 2, one of the two most active compounds of the first series, eleven out of nineteen newly synthesized compounds showed higher anti-allodynic potency, with two of them completely preventing mech. allodynia. In the first series, hit compounds 1 and 2 (I and II) appeared to be inhibitors of p38α MAPK, a protein kinase known to underlie pain hypersensitivity in animal models. Depending on the substitution at the 5-position, some newly synthesized compounds were also stronger p38α MAPK inhibitors. Surprisingly, though, anti-allodynic effects and p38α MAPK inhibitory potencies were not correlated, suggesting that other biol. target(s) is/are involved in the analgesic activity in this series. Altogether, these results confirm that 3,5-disubstituted pyridine-2(1H)-one derivatives are of high interest for the development of new treatment of mech. allodynia. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Ruijng; Xiao, Bo; Li, Wenzuo; Li, Qingzhong published their research in International Journal of Quantum Chemistry in 2021. The article was titled 《Cooperative effects between triel and halogen bonds in complexes of pyridine derivatives: An opposite effect of the nitrogen oxidation on triel and halogen bonds》.Recommanded Product: 15854-87-2 The article contains the following contents:

Ab initio calculations are performed for binary complexes of TrR3···4-PyX/4-OPyX and 4-PyX/4-OPyX···N-base (Tr = B, Al; R = H, Cl, Br, I; X = Cl, Br, I; N-base = HCN, NHCH2, NH3). The halogen bond (XB) is weak but becomes stronger in the HCN(sp) < NH3(sp3) < NHCH2(sp2) pattern. Nitrogen oxidation can enhance the XB a little. The triel bond (TrB) is very strong, with interaction energy ranging from -35 to -58 kcal/mol. The TrB is weaker for the heavier halogen atom in the AlR3 complex, while no such dependence is found in the BR3 complex. The oxygen atom of 4-OPyX engages in a weaker TrB than the nitrogen atom of 4-PyX, inconsistent with the neg. mol. electrostatic potentials (MEPs) on both atoms. Both TrB and XB are strengthened in TrR3···4-PyX/4-PyOX···N-base. The binding distance of the stronger TrB is shortened to less than that of the weaker XB, which is in contrast to that in BF3···NCH···NCH, where the stronger TrB has a larger shortening in the binding distance. The cooperativity is explained by MEP and charge transfer. In the experiment, the researchers used 4-Iodopyridine(cas: 15854-87-2Recommanded Product: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com