Category: 15854-87-2

Tber, Zahira; Loubidi, Mohammed; Jouha, Jabrane; Hdoufane, Ismail; Erdogan, Mumin Alper; Saso, Luciano; Armagan, Guliz; Berteina-Raboin, Sabine published their research in Pharmaceuticals in 2021. The article was titled 《Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents against human neuroblastoma》.Application In Synthesis of 4-Iodopyridine The article contains the following contents:

We report herein the evaluation of various pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents. These mols. were obtained by developing the multicomponent Groebke-Blackburn-Bienayme reaction to yield various pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines which are isosteres of ellipticine whose biol. activities are well established. To evaluate the anticancer potential of these pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amine derivatives in the human neuroblastoma cell line, the cytotoxicity was examined using the WST-1 assay after 72 h drug exposure. A clonogenic assay was used to assess the ability of treated cells to proliferate and form colonies. Protein expressions (Bax, bcl-2, cleaved caspase-3, cleaved PARP-1) were analyzed using Western blotting. The colony number decrease in cells was 50.54%, 37.88% and 27.12% following exposure to compounds 2d, 2g and 4b resp. at 10 ΜM. We also show that treating the neuroblastoma cell line with these compounds resulted in a significant alteration in caspase-3 and PARP-1 cleavage. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Linhua; Zheng, Xuesong; Zheng, Qinze; Li, Zhenlong; Wu, Jian; Gao, Ge published an article in Organic Letters. The title of the article was 《Thioether-Assisted Cu-Catalyzed C5-H Arylation of Imidazo[1,5-a]pyridines》.Application In Synthesis of 4-Iodopyridine The author mentioned the following in the article:

A series of ethylthio (hetero)arylimidazo[1,5-a]pyridine derivatives I (R = 4-methylphenyl, pyridin-4-yl, 1-methyl-1H-indol-5-yl, etc.; R1 = H, Cl, Br, Me, Ph, 4-methoxyphenyl, 4-trifluoromethylphenyl; R2 = H, 6-Cl, 7-Me) was prepared via Cu-catalyzed regioselective C5-H arylation of imidazo[1,5-a]pyridines I (R = H) with aryl iodides RI with the assistance of an ethylthio group at the C3 position. This directing group could be easily removed to furnish a range of 5-(hetero)arylimidazo[1,5-a]pyridine derivatives e.g., II. The reaction tolerates a variety of functionalities and is compatible with sterically hindered substrates. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wen, Ya-Ting; Kong, Xiang-Tao; Liu, Hong-Chao; Wang, Cui-Tian; Wei, Wan-Xu; Wang, Bin; Liu, Xue-Yuan; Liang, Yong-Min published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Remote Radical/Cross-Electrophile Coupling Cascade for Selective C(sp3)-H Arylation》.Synthetic Route of C5H4IN The author mentioned the following in the article:

An innovative 1,5-HAT cascade strategy was advanced for the nickel-catalyzed distal arylation via cross-electrophile coupling. Through specific migration, the remote C(sp3)-H bond was regioselectively activated, and Ar-I as the available electrophile is used for the construction of the C(sp3)-C(sp2) bond. This method also has broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Furthermore, a series of control experiments demonstrated that this reaction was probably initiated by a radical process.4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Dong, Weizhe; Yen-Pon, Expedite; Li, Longbo; Bhattacharjee, Ayan; Jolit, Anais; Molander, Gary A. published an article in Nature Chemistry. The title of the article was 《Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane》.Product Details of 15854-87-2 The author mentioned the following in the article:

Strained bicyclic substructures are increasingly relevant in medicinal chem. discovery research because of their role as bioisosteres. Over the last decade, the successful use of bicyclo[1.1.1]pentane (BCP) as a para-disubstituted benzene replacement has made it a highly valuable pharmacophore. However, various challenges, including limited and lengthy access to useful BCP building blocks, are hampering early discovery research. Here authors report a single-step transition-metal-free multi-component approach to synthetically versatile BCP boronates. Radicals derived from commonly available carboxylic acids and organo halides perform additions onto [1.1.1]propellane to afford BCP radicals, which then engage in polarity-matched borylation. A wide array of alkyl-, aryl- and alkenyl-functionalized BCP boronates were easily prepared Late-stage functionalization performed on natural products and approved drugs proceeded with good efficiency to generate the corresponding BCP conjugates. Various photoredox transformations forging C-C and C-N bonds were demonstrated by taking advantage of BCP trifluoroborate salts derived from the BCP boronates. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Sikun; Liu, Xu; Li, Guoping; Yu, Shi; Yan, Ni; He, Gang published their research in Dyes and Pigments in 2021. The article was titled 《Novel dithienoazaborine viologen derivatives with two different π-conjugated extensions for electrochromic application》.HPLC of Formula: 15854-87-2 The article contains the following contents:

Two kinds of dithienoazaborine viologen derivatives (3a and 3b) with different π-conjugated extensions were synthesized via late-stage functionalization of dithienoazaborine precursor (BNDT). In sharp contrast to 3a (conjugation I), 3b (conjugation II) showed red-shifted absorption (∼468 nm), narrower optical bandgap (2.65 eV), and aggregation-induced emission (AIE) property. Meanwhile, 3b-based electrochromic device (ECD) showed longer switching times (21.6 s for coloration and 34.9 s for bleaching), higher color contrast ratios (21.3%), higher coloration efficiency (13.29 cm2/C), as well as better stability compared with 3a-based ECD. In addition, an electronic information (E-information) tag and a flexible ECD were assembled using 3b, further manifesting its potential applications in display areas. The research not only expands the structural types of viologen derivatives but also compares the effects of different conjugation on the properties of viologen derivatives for the first time, which may provide a feasible way to design new electrochromic materials. In the experimental materials used by the author, we found 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yu, Shilin; Ward, Jas S. published an article in Dalton Transactions. The title of the article was 《Ligand exchange among iodine(I) complexes》.Application In Synthesis of 4-Iodopyridine The author mentioned the following in the article:

A detailed investigation of ligand exchange between iodine(I) ions in [N···I···N]+ halogen-bonded complexes is presented. Ligand exchange reactions were conducted to successfully confirm whether iodine(I) complex formation, via the classical [N···Ag···N]+ to [N···I···N]+ cation exchange reaction from their analogous Ag+ complexes, could be determined solely by using 1H NMR spectroscopy. In instances where the formation of the iodine(I) complex was unclear or in low yield by the traditional cation exchange reaction, a ligand exchange reaction was used to form the desired iodine(I) complexes in a quant. manner. Mixing two homoleptic [N···I···N]+ iodine(I) complexes in 1:1 ratio was found to undergo a statistical ligand exchange, with 1H NMR studies showing that the preferred formation of the relative heteroleptic [N1···I···N2]+ complexes increases with greater differences in the Lewis basicities of two XB acceptors of the complexes involved. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kang, Kang; Li, Lei; Zhang, Meiyu; Miao, Xiaohe; Lei, Lecheng; Xiao, Chengliang published an article in Inorganic Chemistry. The title of the article was 《Two-Fold Interlocking Cationic Metal-Organic Framework Material with Exchangeable Chloride for Perrhenate/Pertechnetate Sorption》.Product Details of 15854-87-2 The author mentioned the following in the article:

Albeit reported substantial sorbents for elimination of TcO4-, the issue of secondary contamination caused by released counterions (such as NO3-) from the cationic metal-organic framework (MOF) has not come into the sufficient limelight for researchers. Herein, our efforts are dedicated to settle the matter through synthesis of NiCl2 based on the cationic MOF (ZJU-X4). Less harmful chlorides are used as exchangeable anions for replacing hazardous anions. Notably, ZJU-X4 exhibited fast sorption kinetics, high sorption capacity of 395 mg/g, decent selectivity, and excellent reusability in four recycles. The results of ion chromatog. revealed that the released chloride ion was equal to sorption of target ions, and pair distribution functions were employed to analyze the changes in ZJU-X4 after sorption of ReO4-, clearly elucidating the anion-exchange mechanism. Furthermore, in the dynamic sorption experiments, ReO4- could be facilely and effectively removed and recovered, showing the value of practical applications. This work indicated that cationic MOF-based metal chloride salts would be a better choice for anionic sorbents. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C5H4INIn 2022 ,《Pyridine-Containing Donor-Acceptor Diarylnitroxides: Noncovalent Stabilization of the Redox States》 appeared in ChemPlusChem. The author of the article were Levitskiy, Oleg A.; Bogdanov, Alexey V.; Klimchuk, Ivan A.; Magdesieva, Tatiana V.. The article conveys some information:

A series of new pyridyl- or 2-pyridyloxide-containing donor-acceptor diarylnitroxides was obtained and characterized; high stability of the ortho-2-pyridyl-containing diarylnitroxides was determined by kinetic measurements (τ1/2=1733 h in benzene). Comparative voltammetric study of new nitroxides and their analog in which the Py replaces the Ph group revealed both through-bond and through-space stabilization of the NO redox states with the pyridyl/ 2-pyridyloxide moiety, providing reversibility of both oxidation and reduction processes. Adaptive conformational behavior of new pyridyl/pyridyloxide containing nitroxides upon one-electron oxidation and reduction was confirmed by DFT calculations Stimuli-responsive conformational changes allow switching on/off dispersion and electrostatic interactions within the mol. and increase stability of the redox states. Spectroelectrochem. measurements provided exptl. evidence for reversibility of the through-space stabilization of the oxidized state of the nitroxides with the neighboring pyridine lone pair. In the experiment, the researchers used 4-Iodopyridine(cas: 15854-87-2Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C5H4INIn 2022 ,《Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications》 was published in Nature Communications. The article was written by Xu, Yuling; Li, Chonglu; Lu, Shuai; Wang, Zhizheng; Liu, Shuang; Yu, Xiujun; Li, Xiaopeng; Sun, Yao. The article contains the following contents:

Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Intermolecular oxyarylation of olefins with aryl halides and TEMPOH catalyzed by the phenolate anion under visible light》 was published in Chemical Science in 2020. These research results belong to Liang, Kangjiang; Liu, Qian; Shen, Lei; Li, Xipan; Wei, Delian; Zheng, Liyan; Xia, Chengfeng. Computed Properties of C5H4IN The article mentions the following:

The phenolate anion was discovered as a new photocatalyst with strong reduction potentials. Under visible light irradiation, the phenolate anion enabled the reduction of (hetero)aryl halides (including electron-rich aryl chlorides) to (hetero)aryl radicals through single electron transfer. Based on this new photocatalyst, a novel and efficient photocatalytic protocol for the intermol. oxyarylation of olefins with aryl halides and 1-hydroxy-2,2,6,6-tetramethylpiperidine was developed. The developed three-component coupling reaction proceeded under redox-neutral reaction conditions with stable and readily available synthons and exhibited broad substrate scope. The utility of this process was further highlighted by the diversified chem. manipulation of the resulting oxyarylation products and the late-stage modification of active pharmaceutical ingredients. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Computed Properties of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com