Category: 15854-87-2

In 2019,Synlett included an article by Lee, Melissa; Adams, Ashley; Cox, Philip B.; Sanford, Melanie S.. Related Products of 15854-87-2. The article was titled 《Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation》. The information in the text is summarized as follows:

In this Letter, authors adapt a recently reported Pd-catalyzed transannular C(sp3)-H arylation of alicyclic amines for applications in fragment-based drug discovery (FBDD). Authors apply this method to the synthesis of a series of 6-arylated 3-azabicyclo[3.1.0]hexanes I (Ar = Ph, 4-ClC6H4, 4-OMeC6H4, 4-Py, 2-Py, etc.) that are rule-of-three compliant fragments. Several modifications were made to the Pd-catalyzed C-H arylation method to enhance its utility in fragment synthesis. These include the use of microwave heating to shorten reaction times to under 1 h and the development of new approaches for directing group cleavage. Finally, authors demonstrate that this fragment library falls within desirable physicochem. space for FBDD applications. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Related Products of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

da Rosa, Rafael; Grand, Lucie; Schenkel, Eloir P.; Sibelle Campos Bernardes, Lilian; Jacolot, Maiwenn; Popowycz, Florence published an article in 2021. The article was titled 《The Use of 5-Hydroxymethylfurfural towards Fine Chemicals: Synthesis and Direct Arylation of 5-HMF-Based Oxazoles》, and you may find the article in Synlett.Recommanded Product: 15854-87-2 The information in the text is summarized as follows:

The synthesis of 5-HMF-based oxazole compounds I [Ar = 4-MeC6H4, 3-FC6H4, 3-thienyl, etc.] were reported. While 5-HMF could be easily converted into the oxazole derivative through the Van Leusen reaction, the direct arylation step needed to access the final compounds was problematic at first. After optimization, a palladium-catalyzed procedure had been developed and used for the synthesis of a series of 33 derivatives This article reported an extension of the late-stage CH arylation reaction as an application to the oxazole platform derived from biosourced 5-HMF. The challenges in the preparation of the derivatives containing some electron-withdrawing substituents were overcome by the use of a palladium-free method. The results came from multiple reactions, including the reaction of 4-Iodopyridine(cas: 15854-87-2Recommanded Product: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Recommanded Product: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Novoa, Nestor; Manzur, Carolina; Roisnel, Thierry; Kahlal, Samia; Saillard, Jean-Yves; Carrillo, David; Hamon, Jean-Rene published an article in 2021. The article was titled 《Nickel(II)-Based Building Blocks with Schiff Base Derivatives: Experimental Insights and DFT Calculations》, and you may find the article in Molecules.HPLC of Formula: 15854-87-2 The information in the text is summarized as follows:

We have recently reported a series of neutral square planar tridentate Schiff base (L) complexes of the general formula [(L)M(py)], showing relatively high first-order hyperpolarizabilities and NLO redox switching behavior. In the present study, new members of this family of compounds have been prepared with the objective to investigate their potential as building blocks in the on-demand construction of D-π-A push-pull systems. Namely, ternary nickel(II) building blocks of general formula [(LA/D)Ni(4-pyX)] (4-7), where LA/D stands for an electron accepting or donating dianionic O,N,O-tridentate Schiff base ligand resulting from the monocondensation of 2-aminophenol or its 4-substituted nitro derivative and β-diketones R-C(=O)CH2C(=O)CH3 (R = Me, anisyl, ferrocenyl), and 4-pyX is 4-iodopyridine or 4-ethynylpyridine, were synthesized and isolated in 60-78% yields. Unexpectedly, the Sonogashira cross-coupling reaction between the 4-iodopyridine derivative 6 and 4-ethynylpyridine led to the formation of the bis(4-pyridyl) acetylene bridged centrosym. dimer [{(LD)Ni}2(μ2-py-CΞC-py)] (8). Complexes 4-8 were characterized by elemental anal., FT-IR and NMR spectroscopy, single crystal X-ray diffraction and computational methods. In each compound, the four-coordinate Ni(II) metal ion adopts a square planar geometry with two nitrogen and two oxygen atoms as donors occupying trans positions. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 15854-87-2In 2022 ,《Bromide as the Directing Group for β-Arylation of Thiophenes》 was published in Synthesis. The article was written by Wang, Cai-Xia; Sheng, Fei-Fei; Liu, Kai-Hui; Gu, Jian-Guo; Shen, Kang; Sun, Zheng-Yi; Hong, Kunlun; Zhang, Hong-Hai. The article contains the following contents:

Direct β-arylation of thiophene derivatives with bromide as directing group was disclosed. The reaction was conducted with PdCl 2/( p-tolyl) 3P as catalyst, silver carbonate as additive and aryl iodide as coupling partner, affording brominated biaryl compounds as product. Control experiments indicated that the presence of bromide group enhances the reactivity of the C-H bond, enabling β-arylation. Furthermore, the C-Br bond was easily converted into many useful functional groups through a wide range of methodologies. The mechanistic study suggested that silver salt plays a key role in the C-H bond-activation step. The results came from multiple reactions, including the reaction of 4-Iodopyridine(cas: 15854-87-2Application of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Application of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Meng, Qi; Zhang, Lian; Zhu, Xinhui; Teng, Qiaoqiao published their research in ChemistrySelect in 2021. The article was titled 《Synthesis of 9-O-Arylated Berberine with a Polystyrene Resin Supported Copper(II) Catalyst》.Safety of 4-Iodopyridine The article contains the following contents:

A series of polyfluorobenzene, pyridine and aniline substituted berberine derivatives I (Ar = Ph, 4-H2NC6H4, 3-pyridyl, etc.) were prepared via resin-supported Cu(II) catalyzed cross-coupling reactions of tetrahydroberberrubine with iodoarenes and subsequent I2 oxidation The best catalyst, a polyethyleneimine functionalized polystyrene supported Cu2+ (PSAPA·Cu(II)), could be reused for at least 5 runs without significant loss of catalytic activity. Comparative studies on the morphol. and porous structures of the materials suggested a catalyst with a moderate sp. surface area and larger pore diameters was more active in catalyzing the cross-coupling reactions.4-Iodopyridine(cas: 15854-87-2Safety of 4-Iodopyridine) was used in this study.

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Supramolecular synthesis with N-hetero-tolanes: liquid crystals and hydrogen-bonded and halogen-bonded co-crystals》 was written by Flores, Linda; Lopez Duarte, Ismael; Gomez-Lor, Berta; Gutierrez-Puebla, Enrique; Hennrich, Gunther. Safety of 4-Iodopyridine And the article was included in CrystEngComm in 2020. The article conveys some information:

Different co-crystals from N-hetero-tolane derivatives are prepared by hydrogen- or halogen-bonding. Their crystal structures have been determined by single crystal X-ray diffraction (SCXRD). Highly ordered smectic liquid crystals are obtained upon protonation of compound 1 and show a remarkable thermal stability. All supramol. aggregates, crystalline or liquid crystalline, are characterized accordingly by X-ray diffraction (XRD), polarized optical microscopy (POM), and thermal anal. (DSC). The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2Safety of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Safety of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Planje, Inco J.; Davidson, Ross J.; Vezzoli, Andrea; Daaoub, Abdalghani; Sangtarash, Sara; Sadeghi, Hatef; Martin, Santiago; Cea, Pilar; Lambert, Colin J.; Beeby, Andrew; Higgins, Simon J.; Nichols, Richard J. published their research in ACS Sensors in 2021. The article was titled 《Selective Anchoring Groups for Molecular Electronic Junctions with ITO Electrodes》.Computed Properties of C5H4IN The article contains the following contents:

Indium tin oxide (ITO) is an attractive substrate for single-mol. electronics since it is transparent while maintaining elec. conductivity Although it has been used before as a contacting electrode in single-mol. elec. studies, these studies have been limited to the use of carboxylic acid terminal groups for binding mol. wires to the ITO substrates. There is thus the need to investigate other anchoring groups with potential for binding effectively to ITO. With this aim, we have investigated the single-mol. conductance of a series of eight tolane or “”tolane-like”” mol. wires with a variety of surface binding groups. We first used gold-mol.-gold junctions to identify promising targets for ITO selectivity. We then assessed the propensity and selectivity of carboxylic acid, cyanoacrylic acid, and pyridinium-squarate to bind to ITO and promote the formation of mol. heterojunctions. We found that pyridinium squarate zwitterions display excellent selectivity for binding to ITO over gold surfaces, with contact resistivity comparable to that of carboxylic acids. These single-mol. experiments are complemented by surface chem. characterization with XPS, quartz crystal microbalance, contact angle determination, and nanolithog. using an at. force miscroscope. Finally, we report the first d.-functional theory calculations involving ITO electrodes to model charge transport through ITO-mol.-gold heterojunctions. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Computed Properties of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Lee, Jaehee; Ju, Xuan; Lee, Miseon; Jiang, Qi; Jang, Hwanjong; Kim, Wan Shin; Wu, Linglin; Williams, Suja; Wang, Xiao-Jun; Zeng, Xingzhong; Payne, Jenna; Han, Zhengxu S. published an article in Organic Letters. The title of the article was 《Copper Catalyzed Regioselective and Stereospecific Aziridine Opening with Pyridyl Grignard Nucleophiles》.Related Products of 15854-87-2 The author mentioned the following in the article:

Copper catalyzed regioselective and stereospecific coupling between aziridines and in-situ generated pyridine Grignard reagents was reported. This method provided β-pyridylethylamines with diverse structures and functionalities from aziridines and iodopyridines. The β-pyridylethylamines were potential scaffolds for the synthesis of biol. active compounds often found in pharmaceuticals. The synthesis of challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed by nucleophilic cyclization.4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2) was used in this study.

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Taylor, Steven J.; Abeywardane, Asitha; Liang, Shuang; Xiong, Zhaoming; Proudfoot, John R.; Farmer, Bennett Sandy; Gao, Donghong A.; Heim-Riether, Alexander; Smith-Keenan, Lana Louise; Muegge, Ingo; Yu, Yang; Zhang, Qiang; Souza, Donald; Panzenbeck, Mark; Goldberg, Daniel; Hill-Drzewi, Melissa; Margarit, Mariana; Collins, Brandon; Li, John Xiang; Zuvela-Jelaska, Ljiljana; Li, Jun; Farrow, Neil A. published an article in 2021. The article was titled 《Indole Inhibitors of MMP-13 for Arthritic Disorders》, and you may find the article in ACS Omega.Synthetic Route of C5H4IN The information in the text is summarized as follows:

Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochem. properties to qualify as tool compounds suitable for in vivo testing. Optimization of potency was guided by structure-based insights, specifically to replace an ester moiety and introduce polar directional hydrogen bonding interactions in the core of the mol. By introducing polar enthalpic interactions in this series of inhibitors, the overall beneficial physicochem. properties were maintained. These physicochem. properties translated to excellent drug-like properties beyond potency. In a murine model of rheumatoid arthritis, treatment of mice with selective inhibitors of MMP-13 resulted in a statistically significant reduction in the mean arthritic score vs. control when dosed over a 14 day period. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Rong-Jia; Zhou, Hou-Gan; Zhang, Zhi-Yin; Ning, Guo-Hong; Li, Dan published their research in CCS Chemistry in 2021. The article was titled 《Copper (I)- organic frameworks for catalysis: networking metal clusters with dynamic covalent chemistry》.COA of Formula: C5H4IN The article contains the following contents:

Metal clusters exhibit diverse structures, emerging functions, and applications; thus, incorporating clus- ters into metal-organic frameworks (MOFs) brings tremendous merits. Although the construction of cluster-based MOFs is sophisticated, the reticular materials constructed from a combination of the chem. of metal clusters and covalent organic frameworks (COFs) remain unexplored. Herein, we prepared two Cu(l) cluster-based MOFs with cyclic trinuclear units (CTUs), termed JNM-1 and JNM-Z, either by a stepwise synthetic approach or by a one-pot reaction, for networking clusters with dy- namic covalent chem., rarely utilized in MOF syn- thesis. The generated JNMs exhibited excellent stability and could be used as recyclable catalysts for palladium-free Sonogashira coupling reactions with high efficiency and tolerance (>90% yield for nine examples), without loss of performance for at least five cycle runs. In addition, conjugated single molec- ular wires with lengths ranging from 1.6 to 2.7 nm were synthesized feasibly using the JNM-1 catalyst. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com