Category: 153898-63-6

Related Products of 153898-63-6,Some common heterocyclic compound, 153898-63-6, name is 2-Iodo-5-methoxyaniline, molecular formula is C7H8INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: a suspension of 3-iodo-4-aminopyridine (1 mmol), methyl 2-mercaptoacetate (1.5 equiv), copper (I) iodide (0.05 mmol), trans-N,N’-dimethylcyclohexane-1,2-diamine (0.1 mmol) and cesium carbonate(2 equiv) in dry 1,4-dioxane (4 mL) in a vial was degassed by bubbling N2 into the suspension for 3 min while stirring. The vial was then capped tightly. The mixture was heated at 100 C (oil bath temperature) for 15 h. After coolingto rt, filtration was carried out. The combined filtrates were concentrated on rotavap and the residue was subjected to silica gel column chromatographpurification (5% methanol in methylene chloride) furnishing 3b as a beige solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodo-5-methoxyaniline, its application will become more common.

Reference:
Article; Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.; Tetrahedron Letters; vol. 54; 38; (2013); p. 5214 – 5216;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 153898-63-6, name is 2-Iodo-5-methoxyaniline, A new synthetic method of this compound is introduced below., COA of Formula: C7H8INO

General procedure: to ortho iodoaniline,1(a-q) (0.10 mmol), in dioxane (5 mL) was added PdCl2 (5 mol %), A-taphos(10 mol %). The solution was purged with nitrogen and stirred at roomtemperature for 10 min and aldehyde (2a-q) (0.16 mmol), CH3COOCs(0.20 mmol), were added. The reaction mixture was again purged withnitrogen and heated in the microwave at 120 C for 30-40 min. Reaction wasmonitored by TLC. After the completion, reaction mixture was cooled to roomtemperature and water was added to the reaction mixture. It was thenextracted with ethyl acetate (25 mL 2) and the separated organic layer wasdried over anhydrous Na2SO4. The organic layer was filtered and concentratedunder vacuum, and the residue was purified by flash column chromatographyon silica gel.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Karuvalam, Ranjith P.; Haridas, Karickal R.; Sajith, Ayyiliath M.; Muralidharan, Arayambath; Tetrahedron Letters; vol. 54; 37; (2013); p. 5126 – 5129;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 153898-63-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153898-63-6, name is 2-Iodo-5-methoxyaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of o-iodoaniline (0.5 mmol, 1 equiv), arylacetic acid (0.6 mmol), elemental sulfur (1.5mmol), Cu(OAc)2·H2O (20 mmol%), and NaOH (1.0 mmol) in DMSO (3 mL) was put into a sealed pressure vessel (25 mL) containing a magnetic stirring bar. The tube was purged with nitrogen three times, and then capped and stirred in a preheated oil bath at 130 C for 24 h. The reaction mixture then cooled to room temperature and extracted with ethyl acetate (3×10 mL), the organic layer was washed with saturated NaCl (2×10 mL), dried over anhydrous Na2SO4, evaporated under vacumm and then purified by silica gel column chromatography by using petroleum ether and ethyl acetate (PE:EA=200:1) as eluent.

The synthetic route of 2-Iodo-5-methoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Xin; Li, Xiaotong; Hu, Renhe; Yang, Zhao; Gu, Ren; Ding, Sai; Li, Pengyi; Han, Shiqing; Synlett; vol. 29; 2; (2018); p. 219 – 224;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153898-63-6, name is 2-Iodo-5-methoxyaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H8INO

General procedure: Bis(triphenylphosphine)palladium(ll) dichloride (32.1 mg, 45.8 muiotatauiotaomicronIota), copper(l) iodide (17.8 mg, 91 .5 muiotatauiotaomicronIota), 2-iodo-5-methoxyaniline (1 .2 g, 4.6 mmol), phenylacetylene (572.5 ml, 5.5 mmol), and diethylamine (10 ml) are refluxed until consumption of the starting materials monitored by TLC. The residue is chromatographed on silica gel (heptane/EE, 10/1 ) to afford 5- Methoxy-2-(phenylethynyl)aniline (818 mg, 3.7 mmol, 80 % of theory).1 H NMR (500 MHz, Chloroform-d) delta 7.54 (d, J = 6.7 Hz, 2H), 7.36 (q, J = 8.9 Hz, 7.7 Hz, 2H), 7.32 (q, J = 8.9 Hz, 8.5 Hz, 2H), 6.34 (dd, J = 8.5 Hz, 2.4 Hz, 1 H), 6.30 (d, J = 2.3 Hz, 1 H), 3.82 (s, 3H).

The synthetic route of 153898-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; SCHRAUB, Martin; DOBELMANN-MARA, Lars; RIEDMUELLER, Stefan; (326 pag.)WO2018/149852; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153898-63-6, name is 2-Iodo-5-methoxyaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Iodo-5-methoxyaniline

The intermediate 3- (3-isopropyl-4-methoxybenzylamino) -1- (3,4,5-trimethoxyphenyl) acetone-2-ynyl (3) (0.20g, 0.52mmol ), 2-iodo-5-methoxyaniline (4) (0.16g, 0.62mmol) was dissolved in dry methanol and a mixture of anhydrous DMSO (1.5), an argon atmosphere, was stirred at 120 60h.After the reaction, by column chromatography (Pe / EtOAc = 7:1) to give a yellow solid intermediate.This intermediate was dissolved in dry of DMF, palladium acetate (11.6mg, 0.052mmol), triethylamine (0.21g, 2.08mmol), stirred for an argon atmosphere 120 14h.After the reaction, by column chromatography (Pe / EtOAc = 5:1) to give a yellow solid, a 2- (4′-methoxy-3′-isopropoxy-phenyl) -3- (3 “, 4”, 5 ‘- trimethoxy-benzoyl) -6-methoxy-indole (5) (131.4mg, the yield 50%).. 1HNMR (500 MHz, CDCl33)delta8.61(s1H)7.93(dJ9.3Hz1H)6.99(s3H)6.91(ddJ4.72.4Hz2H)6.75(ddJ5.03.1Hz2H)4.17(dtJ12.26.1Hz1H)3.86(s3H)3.79(s6H)3.67(s6H)1.20(dJ6.1Hz6H).13C NMR(126MHzCDCl3)delta191.9157.5152.7151.2147.4142.4141.4136.5134.7125.0123.4122.6121.1117.5112.9111.8107.594.771.960.956.155.929.822.1.ESI-MS[M+H]+506.2[M+Na]+528.4.HRMS(ESI)m/z calcd for C29H31NO7[M+H]+506.2173found506.2158

The synthetic route of 153898-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong YizhengdaMedical Technology Co Ltd; Sun, Qing; Zhang, Weidong; (13 pag.)CN104262229; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 153898-63-6, The chemical industry reduces the impact on the environment during synthesis 153898-63-6, name is 2-Iodo-5-methoxyaniline, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 2-iodoanilines (1.0 mmol), THF (3 mL), and t-BuOK (3 mmol) was stirred in a 10-mL sealed Schlenk tube for 5 min, and then dimethylthiocarbamoyl chloride (1.2 mmol) and CuBr (10 mol %) were added. The reaction mixture was heated at 60 C until completion as indicated by TLC. Then the mixture was cooled down to room temperature and quenched with sat. NH4Cl solution (5 mL). The aqueous phase was extracted with EtOAc (3 x10 mL). The combined organic phases were dried (Na2SO4), and the solvent was removed under reduced pressure. The obtained crude product was purified by flash column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-5-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chang, Cai-Zhu; Xu, Wan; Zeng, Meng-Tian; Liu, Min; Liu, Xing; Zhu, Hui; Dong, Zhi-Bing; Synthetic Communications; vol. 47; 13; (2017); p. 1262 – 1267;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 153898-63-6, These common heterocyclic compound, 153898-63-6, name is 2-Iodo-5-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Bis(triphenylphosphine)palladium(ll) dichloride (32,1 mg; 45,8 muiotatauiotaomicronIota), copper(l) iodide (17,8 mg; 91,5 muiotatauiotaomicronIota), 2-lodo-5-methoxyaniline (1,2 g; 4,6 mmol), phenylacetylene (573 ml; 5,5 mmol), and diethylamine (10 ml) are refluxed for 2 h. The residue is chromatographed on silica gel (heptane/EE, 10/1) to afford 5-methoxy-2-(phenylethynyl)aniline (818 mg; 3.7 mmol; 80% of theory). 1H NMR (500 MHz, Chloroform-d) delta 7.54 (d, J = 6.7 Hz, 2H), 7.36 (q, J 8.9, 7.7 Hz, 2H), 7.32 (q, J = 8.9, 8.5 Hz, 2H), 6.34 (dd, J = 8.5, 2.4 Hz, 1H), 6.30 (d, J = 2.3 Hz, 1H), 3.82 (s, 3H).

Statistics shows that 2-Iodo-5-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 153898-63-6.

Reference:
Patent; MERCK PATENT GMBH; DOBELMANN-MARA, Lars; RIEDMUELLER, Stefan; SCHRAUB, Martin; (166 pag.)WO2018/149853; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 153898-63-6, name is 2-Iodo-5-methoxyaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 153898-63-6

To a solution of 2-iodo-5-methoxy-phenylamine 76a (4.05 g, 16.3 mmole) in [10] ml anhydrous CH2CI2 was added TFAA (4.1 g, 19.5 mmole). The mixture was stirred at [36C] overnight, TLC indicated some starting material remained. Additional TFAA (4.1 g, 19.5 mmole) was added and stirred at [38C] for another 24 hours. The mixture was concentrated under rot vap and purified by column chromatography (eluting with 5-10 % EtOAc in hexanes) to give 4. [6 G] product (81% yield). 1H NMR (300 MHz, [CDCI3) B 7.] 92 [(1 H, D, J= 2.] 8 Hz), 7.66 [(1 H, D, J=] 8.9 Hz), 6.59 (1 H, dd, [J=] 2.8, 8.9 Hz), 3.82 (3H, s).

The synthetic route of 153898-63-6 has been constantly updated, and we look forward to future research findings.

153898-63-6, name is 2-Iodo-5-methoxyaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H8INO

Example 76(b) 2,2,2-Trifluoro-N-(2-iodo-5-methoxy-phenyl)-acetamide To a solution of 2-iodo-5-methoxy-phenylamine 76a (4.05 g, 16.3 mmole) in 10 ml anhydrous CH2Cl2 was added TFAA (4.1 g, 19.5 mmole). The mixture was stirred at 36 C. overnight, TLC indicated some starting material remained. Additional TFAA (4.1 g, 19.5 mmole) was added and stirred at 38 C. for another 24 hours. The mixture was concentrated under rot vap and purified by column chromatography (eluding with 5-10% EtOAc in hexanes) to give 4.6 g product (81% yield). 1H NMR (300 MHz, CDCl3) delta7.92 (1H, d, J=2.8 Hz), 7.66 (1H, d, J=8.9 Hz), 6.59 (1H, dd, J=2.8, 8.9 Hz), 3.82 (3H, s).

The synthetic route of 153898-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Agouron Pharmaceuticals, Inc.; US2004/9965; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153898-63-6, name is 2-Iodo-5-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 153898-63-6

General procedure: In a flame-dried flask, AlMe3 (2 M in toluene, 1.11 mL, 2.18mmol, 1.2 equiv) was added to dry toluene (3.0 mL) under anitrogen atmosphere. The mixture was cooled to 0 C, and the2-iodoaniline (2.0 mmol, 1.1 equiv) in dry toluene (4.0 mL) was added. The mixture was stirred for a further 5 min at 0 C. Theice bath was removed, and the mixture was stirred for 20 min atroom temperature. The mixture was cooled to 0 C again, and cyclopentene carboxylate 2b (1.82 mmol, 1.0 equiv) in drytoluene (3.0 mL) was added dropwise over 2 min to the mixture. After stirring for 10 min at 0 C, the mixture was heated to 60 C, and stirring was continued for 16 h. After cooling to room temperature, HCl (1 M, 8.0 mL) was added. (Caution: gas evolution,exotherm.) The mixture was stirred for 15 min, then water (20 mL) and EtOAc (30 mL) were added. The mixture was extracted, the organic phase was separated, and the aqueous phase was re-extracted one more time with EtOAc (30 mL). Thecombined organic phases were washed with brine and dried (MgSO4). After filtration, the solvent was removed under reduced pressure, and the crude mixture was purified by column chromatography.

According to the analysis of related databases, 153898-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Adeyemi, Ahmed; Wetzel, Alexander; Bergman, Joakim; Branalt, Jonas; Larhed, Mats; Synlett; vol. 30; 1; (2019); p. 82 – 88;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com