Category: 15366-65-1

Study of mercaptopyridinecarboxylic acids. I. Synthesis of halo(methoxycarbonyl)-1-methylpyridinium salts was written by Lejeune, R.;Thunus, L.;Lapiere, C. L.. And the article was included in Journal de Pharmacie de Belgique in 1980.Name: 5-Iodonicotinic acid This article mentions the following:

The methiodides I were obtained in 42-6% yield by quaternizing the corresponding pyridines with MeI in the presence of HgCl₂ at 90鎺?for 6 h. I were hydrolyzed to give 60-75% of the diacids. II–IV and some related compounds were prepared by quaternization either in the absence or presence of HgCl₂. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Name: 5-Iodonicotinic acid).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 5-Iodonicotinic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Putative Single-Photon Emission CT Imaging Tracer for Erythropoietin-Producing Hepatocellular A2 Receptor was written by Furukawa, Takenori;Kimura, Hiroyuki;Torimoto, Hanae;Yagi, Yusuke;Kawashima, Hidekazu;Arimitsu, Kenji;Yasui, Hiroyuki. And the article was included in ACS Medicinal Chemistry Letters in 2021.Synthetic Route of C6H4INO2 This article mentions the following:

Erythropoietin-producing hepatocellular (Eph) receptors are receptor tyrosine kinases involved in cell-cell contact. The EphA2 receptor is associated with cancer proliferation and migration. Therefore, EphA2 receptor imaging has the potential for cancer diagnosis. Here, we synthesized N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-5-[¹²³I]iodonicotinamide ([¹²³I]ETB) and evaluated it as an imaging tracer for single-photon emission computed tomog. (SPECT) imaging of the EphA2 receptor. [¹²³I]ETB was designed on the basis of ALW-II-41-27, an inhibitor of EphA2 receptor kinase. Nonradioactive ETB was also synthesized and has been shown to efficiently inhibit EphA2 receptor kinase activity in vitro (IC₅₀: ETB, 90.2 鍗?18.9 nM). A cell-binding assay demonstrated that [¹²⁵I]ETB binds specifically to the EphA2 receptor. The ex vivo biodistribution study of [¹²⁵I]ETB in U87MG tumor-bearing mice also revealed tumor uptake (2.2% ID/g at 240 min). In addition, [¹²³I]ETB uptake in tumors was visualized via SPECT/CT imaging. On the basis of the above, [¹²³I]ETB can be considered a potential SPECT imaging tracer for the EphA2 receptor. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Synthetic Route of C6H4INO2).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C閳ユ彂 bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Synthetic Route of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Inhibition of bacteria by 5-fluoronicotinic acid and other analogs of nicotinic acid was written by Streigbtoff, Frank. And the article was included in Journal of Bacteriology in 1963.HPLC of Formula: 15366-65-1 This article mentions the following:

Several compounds related to 5-fluoronicotinic acid (I) have been demonstrated to inhibit Streptococcus spp. (Viridans group), Staphylococcus aureus, Escherichia coli, and Lactobacillus plan- tarum. The most active compounds were I and 5-fluoronicotin- amide (II). The growth of Streptococcus spp. was inhibited more than 5% by 0.05 γ/ml. of I or 0.5 of II. The inhibition of Streptococcus from 1 part of I or II was reversed by 4 and 2 parts of nicotinic acid, resp. The inhibition of E. coli from 100 parts of I or II was reversed by I part of nicotinic acid. Inhibitions by most other active compounds could be reversed by nicotinic acid. In experiments with mice, 8 compounds related to I had activity against Streptococcus pyogenes; I, II, and 5-fluoro-N-dimethyl- aminomethylnicotinamide protected all mice at 83 mg./kg. The action of 200 mg./kg. I was reversed by 20 mg./kg. of nicotinic acid. The activity of I was not increased by modifica- tions at the number 3 or 5 positions on the pyridine ring or by any other structural changes. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1HPLC of Formula: 15366-65-1).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 15366-65-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Potential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo was written by Carlson, Lars A.;Hedbom, Christina;Helgstrand, Erik;Sjoberg, Berndt;Stjernstrom, Nils E.. And the article was included in Acta Pharmaceutica Suecica in 1972.Recommanded Product: 15366-65-1 This article mentions the following:

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Recommanded Product: 15366-65-1).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 15366-65-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Radioiodination and astatination of octreotide by conjugation labeling was written by Vaidyanathan, G.;Affleck, D.;Welsh, P.;Srinivasan, A.;Schmidt, M.;Zalutsky, M. R.. And the article was included in Nuclear Medicine and Biology in 2000.Category: iodides-buliding-blocks This article mentions the following:

Octreotide was coupled to 3-iodobenzoyl and 3-iodonicotinoyl moieties to obtain [N-(3-iodobenzoyl)-d-Phe¹]octreotide (IBO) and [N-(3-iodonicotinoyl)-d-Phe¹]octreotide (INO), resp. The IC₅₀ values for the binding of IBO and INO to CA20948 rat pancreatic tumor membranes were 0.90 and 0.13 nM, resp., compared with 0.35 nM for octreotide itself. Starting from N-succinimidyl 3-[¹³¹I]iodobenzoate and N-succinimidyl 5-[¹³¹I]iodopyridine-3- carboxylate, [¹³¹I]IBO and [¹³¹I]INO were prepared in overall radiochem. yields of 35%-50%. Likewise, {N-(3-[²¹¹At]astatobenzoyl)-d-Phe¹}octreotide ([²¹¹At]ABO) was prepared in similar yield from N-succinimidyl 3-[²¹¹At]astatobenzoate. In vitro assays with AR42J rat pancreatic tumor cells demonstrated a higher retention of cell-internalized radioiodine activity for [¹³¹I]INO compared with [¹²⁵I]IBO. Tissue distribution studies with both conjugates revealed low levels of activity in the thyroid suggesting that dehalogenation of these peptides was minimal. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Category: iodides-buliding-blocks).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1 was written by Lee, Yujeong;Onishi, Yoshiyuki;McPherson, Lisa;Kietrys, Anna M.;Hebenbrock, Marian;Jun, Yong Woong;Das, Ishani;Adimoolam, Shanthi;Ji, Debin;Mohsen, Michael G.;Ford, James M.;Kool, Eric T.. And the article was included in ACS Chemical Biology in 2022.Category: iodides-buliding-blocks This article mentions the following:

Here, it is reported that selected tyrosine kinase (TK) inhibitors including nilotinib, employed clin. in the treatment of chronic myeloid leukemia, are activators of the repair enzyme Human MutT Homolog 1 (MTH1). MTH1 cleanses the oxidatively damaged cellular nucleotide pool by hydrolyzing the oxidized nucleotide 8-oxo-2′-deoxyguanosine (8-oxo-dG)TP, which is a highly mutagenic lesion when incorporated into DNA. Structural optimization of analogs of TK inhibitors resulted in compounds such as SU0448, which induces 1000 +/- 100% activation of MTH1 at 10μM and 410 +/- 60% at 5μM. The compounds are found to increase the activity of the endogenous enzyme, and at least one (SU0448) decreases levels of 8-oxo-dG in cellular DNA. The results suggest the possibility of using MTH1 activators to decrease the frequency of mutagenic nucleotides entering DNA, which may be a promising strategy to suppress tumorigenesis in individuals with elevated cancer risks. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Category: iodides-buliding-blocks).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com