Synthetic Route of 14548-40-4,Some common heterocyclic compound, 14548-40-4, name is 6-Iodo-1-indanone, molecular formula is C9H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 6-iodo-2,3-dihydro-lH-inden-l-one (5 g, 19.4 mmol) in dichloromethane (300 mL) and methanol (15 mL, saturated with hydrochloride at 0 C) was added a solution of isopentyl nitrite (4.5 g, 38.8 mmol) in dichloromethane (10 mL) over 30 min at 0 C. The resulting solution was stirred for 3 hours at ambient temperature. The solvents were removed partially to about 50 mL followed by the dilution with ether (100 mL). Solid was collected by filtration to give (E)-2- (hydroxyimino)-6-iodo-2,3-dihydroinden-l-one as a light yellow solid: MS (ESI, m/z): 288.1 [M + 1]+; 1H MR (400 MHz, DMSO- 6) delta 12.75 (s, 1H), 8.06-8.01 (m, 2H), 7.46 (d, J = 8.0 Hz, 1H), 3.72 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Iodo-1-indanone, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ABBAS, Walji; HOSTETLER, Eric; GRESHOCK, Thomas; LI, Jing; MOORE, Keith P.; BENNACEF, Idriss; MULHEARN, James; SELNICK, Harold; WANG, Yaode; YANG, Kun; FU, Jianmin; WO2015/188368; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com