Category: 145343-76-6

Stewart, Georgina M. published the artcileSynthesis of substituted 9-oxo-9,10-dihydroacridine-4-carboxylic acids. I. Factors affecting the direction of ring closure of substituted N-(2-carboxyphenylamino)benzoic acids, Quality Control of 145343-76-6, the publication is Australian Journal of Chemistry (1984), 37(9), 1939-50, database is CAplus.

The cyclodehydration of (2-carboxyphenylamino)benzoic acids I (R = NO₂, CO₂H, Cl, Br, etc.) by H₂SO₄, POCl₃, or by Et polyphosphate to give mixtures of dihydroacridinecarboxylic acids II and III depended on the electronic and steric effects of R. Judicious choice of substituent and cyclizing reagent gave a large excess of 1 isomer.

Australian Journal of Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C22H12F6O6S2, Quality Control of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Yuanfei published the artcileCarboxylic Acids as Traceless Directing Groups for the Rhodium(III)-Catalyzed Decarboxylative C-H Arylation of Thiophenes, Computed Properties of 145343-76-6, the publication is Angewandte Chemie, International Edition (2015), 54(12), 3817-3821, database is CAplus and MEDLINE.

A rhodium(III)-catalyzed carboxylic acid directed decarboxylative C-H/C-H cross-coupling of carboxylic acids with thiophenes was developed. With a slight adjustment of the reaction conditions based on the nature of the substrates, arylcarboxylic acids with a variety of substituents served as suitable coupling partners, and a broad variety of functional groups were tolerated. The method provided straightforward access to biaryl scaffolds with diverse substitution patterns, many of which have conventionally been synthesized through lengthy synthetic sequences. An illustrative example was the one-step gram-scale synthesis of biol. active I from 2-(4-methoxyphenyl)thiophene and 2-methoxy-4-methylbenzoic acid.

Angewandte Chemie, International Edition published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C9H9F5Si, Computed Properties of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Katane, Masumi published the artcileIdentification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, Related Products of iodides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1894-1907, database is CAplus and MEDLINE.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohmomo, Yoshiro published the artcileSynthesis and evaluation of iodinated benzamide derivatives as selective and reversible monoamine oxidase B inhibitors, Related Products of iodides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(7), 1789-92, database is CAplus and MEDLINE.

A new series of iodinated analogs of N-(2-aminoethyl)benzamide were synthesized and evaluated for inhibitory potency and specificity toward monoamine oxidase type-B (MAO-B). Among them, N-(2-aminoethyl)-2-chloro-4-iodobenzamide hydrochloride (I) showed high inhibitory potency and selectivity against MAO-B. The type of MAO-B inhibition by I was noncompetitive and the inhibition constant (K_i) was 0.80 μM. Strong and selective in vivo MAO-B inhibition by I was also confirmed. The brain MAO-B inhibition by I was reversible and the enzyme activity completely returned to the control value 24h after administration. Compound I was, therefore, considered to be a candidate for advanced development as a radioiodinated ligand that may be useful for functional MAO-B studies in the living brain using single photon emission computer tomog.

Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohmomo, Yoshiro published the artcileRadioiodinated N-(2-aminoethyl)-2-chloro-4-iodobenzamide: a new ligand for monoamine oxidase B studies with single photon emission computed tomography, Synthetic Route of 145343-76-6, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(4), 913-16, database is CAplus.

In developing monoamine oxidase (MAO)-B specific radioligands, N-(2-aminoethyl)-2-chloro-4-[¹²⁵I]iodobenzamide ([¹²⁵I]FIBA) was conveniently synthesized from its tributylstannyl precursor by an iodostannylation reaction using sodium [¹²⁵I]iodide and hydrogen peroxide with high radiochem. yield. The method should be applicable for labeling with ¹²⁵I, a suitable radioisotope for in vivo imaging with single photon emission computed tomog. (SPECT). In vitro binding studies using mouse brain mitochondrial preparations showed that the specific binding of [¹²⁵I]FIBA was saturable and of high affinity. Calculated values for K_D and B_max were 201 nM and 2.5 pmol/mg protein, resp. The [¹²⁵I]FIBA binding was effectively prevented by MAO-B specific inhibitors (l-deprenyl, Ro 16-6491, FIBA) or substrate (β-phenethylamine). However, MAO-A specific inhibitor (clorgyline) and substrate (serotonin) had no significant effect. After an i.v. injection into mice, [¹²⁵I]FIBA showed high brain uptake (1.64% dose/g at 15-30 min postinjection) and long retention (1.11% dose/g at 120 min postinjection) in the brain. Good brain-to-blood radioactivity ratios of 2.19 and 2.41 at 60 and 120 min after injection, resp., were obtained. The in vitro binding data and in vivo characteristics suggested that [¹²⁵I]FIBA is potentially useful as a probe for biol. studies including specific labeling of MAO-B in vivo as well as in vitro. Moreover, the ¹²³I-labeled counterpart, [¹²⁵I]FIBA, might be valuable for noninvasive imaging and mapping of MAO-B in the living brain with SPECT.

Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Synthetic Route of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kolmel, Dominik K. published the artcileOn-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water, HPLC of Formula: 145343-76-6, the publication is ACS Combinatorial Science (2019), 21(8), 588-597, database is CAplus and MEDLINE.

A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a water-compatible nickel catalysis platform, which is a crucial requirement for the preparation of DNA-encoded libraries (DELs). Together with an iridium-based photocatalyst and a powerful light source, this dual catalysis approach enabled the efficient decarboxylative arylation of α-amino acids with DNA-tagged aryl halides. This C(sp²)-C(sp³) coupling tolerates a wide variety of functional groups on both the amino acid and the aryl halide substrates. Due to the mild and DNA-compatible reaction conditions, the presented transformation holds great potential for the construction of DELs. This was further evidenced by showing that well plate-compatible LED arrays can serve as competent light sources to facilitate parallel synthesis. Lastly, we demonstrate that this procedure can serve as a blueprint toward the adaptation of other established nickel metallaphotoredox transformations to the idiosyncratic requirements of a DEL.

ACS Combinatorial Science published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, HPLC of Formula: 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Yuliang published the artcilePhotoinduced Cross-Coupling of Aryl Iodides with Alkenes, Formula: C7H4ClIO2, the publication is Organic Letters (2021), 23(2), 427-432, database is CAplus and MEDLINE.

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes was developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes was proposed. The method enabled iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

Organic Letters published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Formula: C7H4ClIO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liang, Xinjie published the artcileCopper and L-(-)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air, Name: 2-Chloro-4-iodobenzoic acid, the publication is Tetrahedron Letters (2020), 61(33), 152222, database is CAplus.

L-(-)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95% ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.

Tetrahedron Letters published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Name: 2-Chloro-4-iodobenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pacardo, Dennis B. published the artcileExploring the mechanism of Stille C-C coupling via peptide-capped Pd nanoparticles results in low temperature reagent selectivity, Product Details of C7H4ClIO2, the publication is Catalysis Science & Technology (2013), 3(3), 745-753, database is CAplus.

Stille coupling of PhSnCl₃ with aryl halides was catalyzed by palladium 2 nm nanoparticles, capped with Pd4 peptide, TSNAVHPTLRHL, the effects of halogen, substitution and temperature being qual. evaluated. The atom-leaching mechanism of Pd nanoparticle-driven Stille coupling is suggested, comprising initial oxidative addition at the particle surface, Pd atom abstraction and further reactions in solution The fate of the highly active Pd⁰ atoms released in solution was further elucidated. As a result, two reaction sites are present, the particle surface and pre-leached Pd atoms, thus different degrees of reactivity are possible. This effect was probed via aryl halide combinations that varied the halogen identity allowing for oxidative addition of two substrates simultaneously. The results demonstrate that the system was highly reactive for iodo-based compounds in the mixture at room temperature; however, reactivity at bromo-based substrates was only observed at slightly elevated temperatures of 40.0°. As such, substrate selectivity was evident from the catalytic materials that can be controlled based upon the aryl halide composition and reaction temperature Furthermore, both intermol. and intramol. selectivity is possible, thus raising the degree of reaction complexity that can be achieved.

Catalysis Science & Technology published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Product Details of C7H4ClIO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com