Category: 1450754-38-7

1450754-38-7, These common heterocyclic compound, 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(g) Compound 6 (400 mg, 1.6 mmol, 1.0 eq), sodium azide (125 mg, 1.92 mmol, 1.2 eq) and DMF (4 ml) were added to a reaction flask, and the temperature was raised to 70 C, and the reaction was carried out for 5 hours in the dark;Quenched with water, extracted with ethyl acetate, dried and dried to give a crude200 mg of compound 7, yield: 76%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1450754-38-7.

Reference:
Patent; Suzhouguangdian Biological Technology Co., Ltd.; Ni Runyan; Wang Wei; (8 pag.)CN109369532; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H9IN2

(g) Compound 6 (400 mg, 1.6 mmol, 1.0 eq), sodium azide (125 mg, 1.92 mmol, 1.2 eq) and DMF (4 ml) were added to the reaction flask.Raise to 70 C, avoid light reaction for 5 hours; add water to quench,Extract with ethyl acetate, dry, spin dry,A crude product of 200 mg of compound 7,Yield: 76%.

The synthetic route of 1450754-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Suzhouguangdian Biological Technology Co., Ltd.; Ni Runyan; Wang Wei; (8 pag.)CN109503615; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

The steviol (30mg, 0.1mmol), K2CO3 (27mg, 0.2mmo 1) added to the dry flask, replace the nitrogen, then added 2mL anhydrous N, N-dimethylformamide (DMF), 3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine (1-1) (33mg0.13mmol) dissolved in 1mL N, N-dimethyl formamide, then added to the reaction under ice bath, and the mixture was heated to 70 C, and reacted for 6 hr. The mixture was subjected to thin layer chromatography (TLC), washed with 10% HCl, after washing with saturated brine and it was dried over anhydrous sodium sulfate and separation by column chromatography gave molecular probe 1 (white solid, 34 mg, 92% yield).

The synthetic route of 1450754-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Life Sciences Institute; Xiao Youli; Li Weichao; Zhou Yiqing; (27 pag.)CN108341781; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 1450754-38-7, A common heterocyclic compound, 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, molecular formula is C7H9IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 500-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 3-(but-3-yn-l-yl)-3-(2-iodoethyl)-3H-diazirine (5.0 g, 20.2 mmol) in DMF (250 mL), KCN (2.62 g, 40.3mmol). The resulting solution was stirred for 16 h at 60 C in an oil bath. The reaction was then quenched by the addition of 20 mL of FeS04solution. The resulting solution was extracted with 3×50 ml of ethyl acetate dried over anhydrous sodium sulfate. The solids were filtered out. The resulting mixture was concentrated. This resulted in 2.0 g (crude) of the title compound as a solid. MS-ESI: 148 (M+l).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; IFM TRE, INC.; GLICK, Gary; ROUSH, William R.; VENKATRAMAN, Shankar; SHEN, Dong-Ming; GHOSH, Shomir; KATZ, Jason; SEIDEL, Hans Martin; FRANCHI, Luigi; WINKLER, David Guenther; OPIPARI JR., Anthony William; (783 pag.)WO2019/23147; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1450754-38-7, A common heterocyclic compound, 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, molecular formula is C7H9IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine (70 mg, 282 imol, 1 eq) and 4- hydroxybenzaldehyde (34.5 mg, 282 imol, 1 eq) in 1 mL of DMF was added Cs2CO3 (276 mg, 847 imol, 3 eq) in one portion at 15C under N2. The mixture was stirred at 60 C for 12 hours.The residue was poured into 2 mL water. The aqueous phase was extracted with three 1 mL portions of ethyl acetate. The combined organic phases were washed twice with 2 mL of brine, dried with anhydrous Na2SO4, filtered and concentrated in vacuo to give 40 mg of crude aldehyde A-i as yellow oil which was used into the next step without further purification.

The synthetic route of 1450754-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1450754-38-7 as follows. Product Details of 1450754-38-7

To a mixture of 3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine (70 mg, 282 imol, 1 eq) and 3- hydroxybenzaldehyde (34.5 mg, 282 imol, 1 eq) in 1 mL of DMF was added Cs2CO3 (276 mg, 847 imol, 3 eq) in one portion at 15C under N2. The mixture was stirred at 60 C for 12 hours.The reaction mixture was diluted with 3 mL of H20 and extracted three times with 9 mL of EtOAc. The combined organic layers were washed twice with 6 mL of brine, dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by prep-TLC (Si02, eluting with petroleum ether: ethyl acetate = 3:1) to give 40 mg of crude A-2 as colorless oil.

According to the analysis of related databases, 1450754-38-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1450754-38-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450754-38-7 name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

K2CO3 (0.207g, 1.5 mmoL) and L3 (0.248g, 1.0 mmoL) were added orderly to a solution of phenol (0.113g, 1.2 mmoL) in DMF (10mL). The reaction mixture was stirred at 50C for 16h and monitored by TLC. The reaction was quenched by adding H2O (5mL). The crude product was exacted into EtOAc (3×10mL). The combined organic layers were washed with brine (10mL), and dried over Na2SO4 and then filtered. The filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography giving NP as colorless oil (171mg, yield 80%). 1H NMR (300MHz, CDCl3) delta 7.34-7.28 (m, 2H), 7.01-6.95 (m, 1H), 6.94-6.88 (m, 2H), 3.85 (t, J=6.2Hz, 2H), 2.13-2.06 (m, 2H), 2.01 (t, J=2.6Hz, 1H), 1.91 (t, J=6.2Hz, 2H), 1.80-1.73 (m, 2H). 13C NMR (75MHz, CDCl3) delta 158.4, 129.5, 121.1, 114.5, 82.8, 69.2, 62.4, 33.0, 32.7, 26.7, 13.3. Purity: 97.13% by (0.01M KH2PO4 solution: MeOH=15: 85).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, and friends who are interested can also refer to it.

Some common heterocyclic compound, 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, molecular formula is C7H9IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

A mixture of compound S4 (90.0 mg, 286 lirnol, I equiv), and iodo-diazirine S7 (70.0 mg, 286 imol, 1.00 equiv) was dissolved in DMF (3.0 rnL) at 24 C. To this mixture, was added potassium carbonate (40.0 mg, 286 umol, 100 equiv) and stirred for 12 hours at 24 C. The reaction mixture was partitioned between ethyl acetate (30 mL) and DI water (15 mL) and the organic portion was separated and washed with brine (3 x 15 mL). The combined organic portion was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford an off white powder. The powder was purified by flash column chromatography (30—60% ethyl acetate–hexane, three steps) to afford photo-celecoxib (5) as a white powder (92.0 nig, 75Rf = 0.20 (40% ethyl acetate—hexane; UV). ?H NMR (500 MHz, CDCI3): oe 8.05 (d, 21-1, J 8.2 Hz, H3). 8.02 (d, 2H, J 8.1 Hz, Fl4), 5.95 (s, iH, H?), 5.13 (br, 2H, H5), 4.04 (t,21-1, J 7.2 Hz, H2). 2.05—2.03 (in, 51-1, E-16/I-18/H9), i.71—i.69 (in, 21-1. H7). ?3C N]?[R (125 MIz, CDCI3): d 154.6 (C), 143.0 (q, 2JCF = 38.8 Hz, CH), 141.1 (C), 140.4 (C), 127.6 (CH), 122.5 ((1-1), 121.7 (q, IJCF 267.5 Hz CF3), 5.3 (C), 82.4 (C), 69.7 (CH). 67.6 (OCH2),32.4 (CH2), 32.1 (CH2), 26.1 (CN2), 13.2 (CH3). ?9FvR(375 MHz, CDCI3): -63.6. IR (ATR-FT1R), cnf?: 3277 (br), 1590 (s), 1563 (m), 1512 (m), 1490 (w), 1416 (m), 1380 (w), 1335 (w), 1246 (m), 1151 (rn), 1101 (rn), 968 (w), 908 (w), 40 (w), 743 (w), 715 (w), 626 (in), 543 (w). HRMS-ES1 (m/z): [M+F1] calculated for Ci7H,7F3NsO3S, 428,0999; found,428.0949.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1450754-38-7, its application will become more common.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; WOO, Christina, M.; GAO, Jinxu; (555 pag.)WO2018/226828; (2018); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1450754-38-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, A new synthetic method of this compound is introduced below.

A mixture of compound S9 (38.1 mg, 167 tmo1, I equiv) and iodo-diazirine 57 (41.4 mg, 178 p.moi, 1.00 equiv) was dissolved in DMF (1.7 rnL) at 24 C. Potassium carbonate (46.1 rng, 334 imol, 2.00 equiv) was added to the resulting mixture. The reaction mixture was stirred for 12 hours at 50 C, then cooled for 30 minutes to 24 C and partitioned between ethyl acetate (5 mL) and Di water (5 mL). The organic portion was separated and washed with brine (3 x 5 mL). The organic portion was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford an off white powder. The powder was purified by flash column chromatography (20% ethyl acetate-hexanes) to afford the celecoxib analog 9 as a pale yellow oil (39.4 mg, 68%).R= 0.58 (20% ethyl acetate-hexanes; UV). ?HNIvR (500 MHz, CDCI3): d 7.74 (d, 2H, J 7,6 Hz, El3). 7.48 (dd, 2H, J == 7.6, 7.6 Hz, H4), 7.36 (t, IH, J == 7.6, 7.6 Hz, H5), 5.92 (s, IH, Hi), 3.99 (t, 2H, J = 6.0 Hz, H2), 2.01-195 (m, 5H, Ho/HfHc), 1.66 (t, 2H, J = 6.8 Hz, FL). ?3C NMR (125 MHz, CDC13): oe 154.0 (C), 141.8 (q, 2JCF 38.4 Hz, CT:1), 137.5 (C), 129.0 (CH), 127.7 (CH). 123.0 (CH), 120.9 (q, IJCF = 267.3 Hz CF3), 84.7 (q, 3JCF = 2. 1 Hz, CH), 82.4 (C), 69.4 (CH), 67.1 (OCH2), 32.6 (CFL), 32.3 (Cl-i2), 26.1 (CN2), 13.2 (CH3). ?9F NMR (375 MHz, CDCI3): oe -63.3 ppm. [R (ATR-FTIR). cnf?: 3303 (s), 1594 (m). 1562(m), 1508 (rn), 1488 (m), 1457 (m), 1243 (s), 1126 (s), 1099 (s), 968 (s), 759 (s), 639 (s) cm- 1. HRMS-ESI (m/z): [MH-+1j calculated ?for Cv7HT6F3N4O. 34g. 1271; found, 349.1276.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; WOO, Christina, M.; GAO, Jinxu; (555 pag.)WO2018/226828; (2018); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1450754-38-7, These common heterocyclic compound, 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(g) Compound 6 (400 mg, 1.6 mmol, 1.0 eq), sodium azide (125 mg, 1.92 mmol, 1.2 eq) and DMF (4 ml) were added to a reaction flask, and the temperature was raised to 70 C, and the reaction was carried out for 5 hours in the dark;Quenched with water, extracted with ethyl acetate, dried and dried to give a crude200 mg of compound 7, yield: 76%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1450754-38-7.

Reference:
Patent; Suzhouguangdian Biological Technology Co., Ltd.; Ni Runyan; Wang Wei; (8 pag.)CN109369532; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com