Category: 1443278-79-2

Huang, Zhuo-Bin published the artcileSelective C-H dithiocarbamation of arenes and antifungal activity evaluation, Application of 4-Iodo-1-methyl-1H-pyrazol-5-amine, the publication is Organic & Biomolecular Chemistry (2020), 18(7), 1369-1376, database is CAplus and MEDLINE.

This paper discloses a transition metal-free selective C-H dithiocarbamation of drug skeletons using disulfiram (DSF) in the presence of KI/K₂S₂O₈ in DMF/H₂O. Drug skeletons, including 5-aminopyrazoles, indoles, pyrroloquinoline, and Julolidine, underwent C-H dithiocarbamation smoothly to afford a variety of drug-like mols. in moderate to good yields. It was found that the in situ formed 5-aminopyrazole iodide is the key intermediate for the dithiocarbamation. Bioassay results show that some of these N-heterocyclic dithiocarbamate derivatives exhibit good antifungal activity against Colletotrichum gloeosprioides and Fusarium oxysporum, F. proliferatum, Fusarium solani, Geotrichum candidum, Penicillium digitatum, Penicillium italicum, Pyricularia grisea.

Organic & Biomolecular Chemistry published new progress about 1443278-79-2. 1443278-79-2 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Amine, name is 4-Iodo-1-methyl-1H-pyrazol-5-amine, and the molecular formula is C4H6IN3, Application of 4-Iodo-1-methyl-1H-pyrazol-5-amine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reeves, Jonathan T. published the artcileCopper-catalyzed annulation of 2-formylazoles with aminoiodopyrazoles: Synthesis of new heterocyclic ring systems, Name: 4-Iodo-1-methyl-1H-pyrazol-5-amine, the publication is Journal of Heterocyclic Chemistry (2013), 50(3), 680-683, database is CAplus.

Various 2-formyl azoles underwent CuI/sparteine-catalyzed annulation with 1-substituted 4-iodo-5-aminopyrazoles to produce pyrazolo[3,4-e]pyrrolo[1,2-a]pyrazines and imidazo[1,2-a]pyrazolo[3,4-e]pyrazines. The reaction was demonstrated for 2-formylpyrroles, 2-formylindoles, 2-formylimidazole, and 3-methyl-5-formylpyrazole. 3-Substitution of the iodopyrazole was tolerated.

Journal of Heterocyclic Chemistry published new progress about 1443278-79-2. 1443278-79-2 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Amine, name is 4-Iodo-1-methyl-1H-pyrazol-5-amine, and the molecular formula is C4H6IN3, Name: 4-Iodo-1-methyl-1H-pyrazol-5-amine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stambirskyi, Maksym V. published the artcilePhosphine Oxides (-POMe₂) for Medicinal Chemistry: Synthesis, Properties, and Applications, Recommanded Product: 4-Iodo-1-methyl-1H-pyrazol-5-amine, the publication is Journal of Organic Chemistry (2021), 86(18), 12783-12801, database is CAplus and MEDLINE.

A general practical approach to hetero(aromatic) and aliphatic P(O)Me₂-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me₂. The P(O)Me₂ substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.

Journal of Organic Chemistry published new progress about 1443278-79-2. 1443278-79-2 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Amine, name is 4-Iodo-1-methyl-1H-pyrazol-5-amine, and the molecular formula is C10H9ClN2O, Recommanded Product: 4-Iodo-1-methyl-1H-pyrazol-5-amine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com