Category: 1391728-13-4

Gruber, Stefan; Waser, Valerie; Thiel, Zacharias; Ametamey, Simon M. published the artcile< Prodrug Approach toward the Development of a PET Radioligand for Imaging the GluN2A Subunits of the NMDA Receptor>, Application In Synthesis of 1391728-13-4, the main research area is fluorine 18 labeled prodrug AFA233 phosphate ester preparation.

A straightforward synthesis of a F-18-labeled prodrug of AFA233 is reported. The key step in the preparation of [18F]AFA233-prodrug is the selective deprotection of the tert-Bu protection groups of the quinoxalinedione moiety without cleavage of the tert-butyl-S-acyl-2-thioethyl protection groups on the phosphate esters. The preparation of the nonradioactive prodrug reference compound of AFA233 is reported.

Organic Letters published new progress about Imaging (F-18-labeled prodrug AFA233). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Application In Synthesis of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xu, Kang; Yang, Ruiqi; Yang, Shuang; Jiang, Cheng; Ding, Zhenhua published the artcile< Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles>, Quality Control of 1391728-13-4, the main research area is vinyl acetamide preparation fluoro dimethylbenziodoxole boron trifluoride etherate heterocyclization; aryl methyloxazole preparation; acetamido phenylacrylate preparation nitrile fluoro dimethylbenziodoxole zinc fluoroborate cyclocondensation; phenyl imidazolyl carboxylate preparation.

A hypervalent iodane reagent used for the intramol. cyclization of N-acetyl enamines and intermol. cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles resp., in moderate to excellent yields. This transformation exhibited good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermol. reaction was depended on the structure of N-acetyl enamines.

Organic & Biomolecular Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Quality Control of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cortes Gonzalez, Miguel A.; Jiang, Xingguo; Nordeman, Patrik; Antoni, Gunnar; Szabo, Kalman J. published the artcile< Rhodium-mediated 18F-oxyfluorination of diazoketones using a fluorine-18-containing hypervalent iodine reagent>, Electric Literature of 1391728-13-4, the main research area is alpha fluoro ether preparation; diazoketone trimethyl orthoformate oxyfluorination rhodium catalyst.

Geminal 18F-oxyfluorination of diazoketones was performed in the presence of rhodium catalyst and hypervalent iodine-based [18F]fluoro-benziodoxole reagent to get various α-[18F]fluoro ethers I [R = Ph, 2-furyl, 4-MeC6H4, etc.] in high radiochem. yield (up to 98%) and molar activity (216 GBq μmol-1).

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Shuang; Shi, Shoujie; Chen, Yuhang; Ding, Zhenhua published the artcile< Synthesis of Dihydroxazines and Fluorinated Oxazepanes Using a Hypervalent Fluoroiodine Reagent>, Recommanded Product: 1-Fluoro-3,3-dimethyl-1,2-benziodoxole, the main research area is dihydroxazine fluorinated oxazepane preparation hypervalent fluoroiodine reagent; regiodivergent synthesis allylaminoethanol starting material.

Application of a hypervalent fluoroiodane for the regiodivergent synthesis of dihydroxazines and fluorinated oxazepanes from allylaminoethanol was investigated. The reaction was carried out under mild conditions and gave the products in moderate to good yields. The selectivity of this transformation is controlled by the substituents of the allylaminoethanol.

Journal of Organic Chemistry published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Recommanded Product: 1-Fluoro-3,3-dimethyl-1,2-benziodoxole.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Jin-Dong; Li, Man; Xue, Xiao-Song published the artcile< Computational I(III)-X BDEs for Benziodoxol(on)e-based Hypervalent Iodine Reagents: Implications for Their Functional Group Transfer Abilities>, Product Details of C9H10FIO, the main research area is benziodoxol bond dissociation energy substituent steric effect.

Summary of main observation and conclusion : The first comprehensive I(III)-X (X = F, Br, CN, N3, CF3, etc.) bond dissociation energy (BDE) scales for benziodoxol(on)e-based hypervalent iodine reagents have been developed by virtue of DFT calculations Excellent correlation is observed between the I(III)-X BDEs and the X-H BDEs, offering a powerful avenue to quickly estimate the group-transfer ability of a novel benziodoxol(on)e-based hypervalent reagent.

Chinese Journal of Chemistry published new progress about Bond cleavage. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Product Details of C9H10FIO.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rahimidashaghoul, Kheironnesae; Klimankova, Iveta; Hubalek, Martin; Korecky, Michal; Chvojka, Matus; Pokorny, Daniel; Matousek, Vaclav; Fojtik, Lukas; Kavan, Daniel; Kukacka, Zdenek; Novak, Petr; Beier, Petr published the artcile< Reductant-induced free radical fluoroalkylation of nitrogen heterocycles and innate aromatic amino acid residues in peptides and proteins>, HPLC of Formula: 1391728-13-4, the main research area is peptides protein synthesis reductant induced free radical fluoroalkylation tryptophan; nitrogen heterocycle amino acid fluoroalkylation bioconjugation fluorine iodine radical; myoglobin ubiquitin human carbonic anhydrase functionalization mol modeling; fluoroalkylation reaction mechanism sodium ascorbate catalyst; bioconjugation; fluorine; iodine; radicals; tryptophan.

A series of fluoroalkylated cyclic λ3-iodanes and their hydrochloride salts was prepared and used in a combination with sodium ascorbate in buffer or aqueous methanol mixtures for radical fluoroalkylation of a range of substituted indoles, pyrroles, tryptophan or its derivatives, and Trp residues in peptides. As demonstrated on several peptides, the aromatic amino acid residues of Trp, Tyr, Phe, and His are targeted with high selectivity to Trp. The functionalization method is biocompatible, mild, rapid, and transition-metal-free. The proteins myoglobin, ubiquitin, and human carbonic anhydrase I were also successfully functionalized.

Chemistry – A European Journal published new progress about Fluoroalkylation. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, HPLC of Formula: 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Yuhang; Zhang, Dingcheng; Sun, Mingze; Ding, Zhenhua published the artcile< Divergent synthesis of isoxazoles and 6H-1,2-oxazines via hypervalent iodine-mediated intramolecular oxygenation of alkenes>, Electric Literature of 1391728-13-4, the main research area is isoxazoles preparation; oxazine preparation; alkene intramol oxygenation hypervalent iodine mediated.

The divergent synthesis of isoxazoles I [R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = Ph, 2-naphthyl, 2-furyl, etc.] and 6H-1,2-oxazines II [R3 = Me, CH(Me)2, cyclohexyl, Bn; Ar = Ph, 4-FC6H4, 2-naphthyl, etc.] was realized using a hypervalent fluoroiodane reagent from β,γ-unsaturated oximes. The formation of a five- or six-membered ring is controlled by the substituents of the substrates combined with the reaction conditions. The reaction was performed under mild conditions and gave the products in moderate to good yields.

New Journal of Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kiefl, Gabriel M.; Gulder, Tanja published the artcile< α-Functionalization of Ketones via a Nitrogen Directed Oxidative Umpolung>, Related Products of 1391728-13-4, the main research area is alpha functionalization pyridyl ketone oxidative umpolung hypervalent fluorine iodane; regioselective oxidative functionalization.

Reversing the polarity in mols. is a versatile tool for expanding the boundaries of structural space. Despite a manifold of different umpolung methods available today, overcoming the inherent reactivity still remains a constant challenge in organic chem. The oxidative α-functionalization of ketones by external nucleophiles constitute such an example. Herein, we present a hypervalent F-iodane mediated umpolung of pyridyl ketones triggered by Lewis base/Lewis acid noncovalent interactions. A wide variety of external nucleophiles are introduced with high regioselectivity applying this substrate-directing concept.

Journal of the American Chemical Society published new progress about Directing groups. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Related Products of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com