Category: 132131-24-9

Synthetic Route of 132131-24-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132131-24-9, name is 2-Amino-5-iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Alternative Synthesis of iV-(4-moipholinophenyl)-6-(4-(4-morphoIinophenyIamino)quinazolin-6-yl)quinazolin-4-amine; N’-(2-Cyano-4-iodo~phenyl)-N,N-dimethyl-formamidine:2-Amino-5-iodo-benzonitrile (5g, 20.5mmol) was heated to reflux in DMF-DMA (20ml) for 2h. On cooling and concentrating to dryness in vacuo the residue was filtered through silica (2Og, SiO2) eluting with dichloromethane to afford a brown oil (6.15g, 100%)1H NMR (CDCl3) delta 7.71 ( IH, d), 7.58 ( IH, dd), 7.505 ( IH, s), 6.64 (IH, d), 3.01 (6H, s)LC-MS rt 3.46 m/z 299 MH+; Example 2; N*4*-(4-Morpholin-4-yI-phenyl)-N*4*-phenyl-[6,6′]biquinazolinyl-4,4′- diamine; N’-(2-Cyano-4-iodo-phenyl)-N,N-dimethyl-formamidine; 2-Amino-5-iodo-benzonitrile (5g) in DMF-DMA ( 10ml) was heated to 110 for 2h. The cooled reaction mixture was diluted with water (100ml) and extracted into ethyl acetate (3xl00ml). The combined organic phases were dried (MgSO4) and concentrated to give a viscous brown oil (~ quantitative) which was used without further purification.1H NMR (CDCl3) delta 7.77 (IH, m), 7.65 (IH, dm, J8.85Hz), 7.57 (IH, s), 6.70 ( IH, d,J8.85Hz), 3.012 (6H, s)LC-MS rt 3.46 m/z 299.78

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2006/79833; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 132131-24-9, name is 2-Amino-5-iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 132131-24-9, Recommanded Product: 132131-24-9

(ii) Preparation of N’-(2-cyano-4-iodo-phenyl)-N,N-dimethyIformamidine (8): Into a 500 ml 3 necked round bottomed flask, N, N-dimethylforamide (100 ml), 2- amino-5-iodobenzonitrile (50g) obtained by the process given in the above step (i) and Nu,Nu-dimethyl formamide dimethyl acetate (51.3 g) were charged. The reaction mass was maintained at 70-75 C for about 2 Hrs. The completion of the reaction was monitored by TLC. The reaction mass was cooled to 25-35 C and quenched into ice water and maintained for about 2 Hrs. at 0-5 C. The product was filtered and dried under vacuum at 25-35 C to get 58 g of N’-(2-cyano-4-iodo-phenyl)-N,N- dimethylforrnamidine as a pale yellow coloured amorphous powder. Melting range: 53-55 CHPLC purity: 99.8%

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-5-iodobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; NATCO PHARMA LIMITED; JYOTHI PRASAD, Ramanadham; ADIBHATLA KALI SATYA, Bhujanga rao; VENKAIAH CHOWDARY, Nannapaneni; WO2011/39759; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com