Reference of 13194-67-7, These common heterocyclic compound, 13194-67-7, name is 4-Fluoro-2-iodo-1-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-Bromosuccinimide (NBS, 3.77 g, 21.2 mmol) and benzoyl peroxide (77 mg,0.32 mmol) were added to a solution of 4-fluoro-2-iodo-1-methylbenzene 10d (5 g, 21.2 mmol) inCCl4 (55 mL). The mixture was heated to reflux for 60 hours then cooled to room temperature. The mixture was concentrated under reduced pressure. Purification over silica eluting with pentane provided the title compound as a white solid (3.67 g, 52% yield). 1H NMR (400MHz, CDCl3):d 7.57 (dd, 1H), 7.45 (dd, 1H), 7.06 (m, 1H), 4.58 (s,2H); Also a known commercially available compound.
Statistics shows that 4-Fluoro-2-iodo-1-methylbenzene is playing an increasingly important role. we look forward to future research findings about 13194-67-7.
Reference:
Article; Roberts, Lee R.; Corbett, Matthew S.; Fussell, Steven J.; Hitzel, Laure; Jessiman, Alan S.; Mason, Helen J.; Osborne, Rachel; Ralph, Michael J.; Stennett, Adam S.D.; Wheeler, Simon; Storer, R. Ian; Tetrahedron Letters; vol. 56; 47; (2015); p. 6546 – 6550;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com