Category: 1309788-50-8

These common heterocyclic compound, 1309788-50-8, name is 3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole

Step 4: iert-Butyl 3-iodo-6,6-dimethyl-4,5,6,7-tetrahydro-lH-indazole-l-carboxylate: To a stirred solution of step 3 intermediate (3.9 g, 14.124 mmol) in dry tetrahydrofuran (20 ml), triethylamine (2.08 ml, 14.83 mmol), 4-dimethylaminopyridine (68 mg, 0.565 mmol) were added followed by addition of di-tert-butyl bicarbonate (3.23 g, 14.83 mmol) at room temperature and reaction mixture was stirred for 1 h at same temperature. The solvent was evaporated under reduced pressure and product was purified by column chromatography to yield 5.24 g of product as a pale yellow solid. 1H NMR (300 MHz, CDC13): delta 1.00 (s, 6H), 1.50 (t, / = 6.6 Hz, 2H), 1.59-1.69 (m, 9H), 2.31 (t, / = 6.3 Hz, 2H), 2.67 (s, 2H).

The synthetic route of 3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; KUMAR, Sukeerthi; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; WO2014/41518; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 1309788-50-8, name is 3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1309788-50-8, SDS of cas: 1309788-50-8

To a solution of 3-iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole (41 g, 147 mmol), triethylamine (22 ml, 155 mmol) and 4-dimethylaminopyridine (824 mg, 7 mmol) in tetrahydrofuran (163 ml) was added dropwise a solution of di-tert-butyl dicarbonate (34 g, 155 mmol) in tetrahydrofuran (41 ml) at room temperature over 40 min, and the mixture was stirred for 30 min. Then, the reaction mixture was is concentrated under reduced pressure. The residue was slurry-washed in hexane (130 ml) at 60 C. and ice-cooled. The crystals were collected by filtration, washed with hexane, and dried under reduced pressure to give the title compound (53 g, yield 95%).1H-NMR (400 MHz, DMSO-d6) delta: 0.95 (s, 6H), 1.46 (t, 2H, J=6.38 Hz), 1.56 (s, 9H), 2.23 (t, 2H, J=6.26 Hz), 2.63 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JAPAN TOBACCO INC.; US2011/306599; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com