Category: 1271523-34-2

Synthetic Route of 1271523-34-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1271523-34-2, name is 1,5-Dichloro-2-iodo-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

2-(2,4-Dichloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-l,3,2-dioxaborolane (11a)To a solution of l,5-dichloro-2-iodo-3-methoxybenzene (10a) (21.0g, 69.3mmol) in THF (250ml) was sequentially added Cul (1.32g, 6.9mmol) and NaH (60%> dispersion in mineral oil, 4.2g, 104mmol), followed by a slow addition of pinacolborane (15.1ml, 104mmol). The resulting suspension was stirred at room temperature for 16 h under a N2 atmosphere, and then quenched with saturated NH4CI (250ml). After 20 min, the reaction mixture was extracted with EtOAc (x3), dried and then filtered over Celite. Concentrated and purification by column chromatography (Si02; EtOAc:PE 0:1?1 :9) to afford the title boronate as a white solid; (15. lg, 72%).NMR (CDCI3) 6.87 (1H, d, J 1.6), 6.63 (1H, d, J 1.6), 3.37 (3H, s), 1.32 (12H, s);MS (m/e) No MI observed, Rt 1.17min (QC Method 1)

The chemical industry reduces the impact on the environment during synthesis 1,5-Dichloro-2-iodo-3-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; WO2011/151652; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 1271523-34-2, A common heterocyclic compound, 1271523-34-2, name is 1,5-Dichloro-2-iodo-3-methoxybenzene, molecular formula is C7H5Cl2IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 11a (21.0g, 69.3mmol) in THF (250ml) was sequentially added Cul (1.32g, 6.9mmol) and NaH (60% dispersion in mineral oil, 4.2g, 104mmol), followed by a slow addition of pinacolborane (15.1ml, 104mmol). The resulting suspension was stirred at room temperature for 16 h under a N2 atmosphere, and then quenched with saturated NH4CI (250 ml). After 20 min, the mixture was extracted with EtOAc (x3), dried and then filtered over Celite. Concentrated and purification by column chromatography (Si02; EtOAc:PE 0: 1?3:7) to afford the title boronate as a white solid; (15. lg, 72%)NMR (CDC13) 6.87 (IH, d, J 1.6), 6.63 (IH, d, J 1.6), 3.37 (3H, s), 1.32 (12H, s);MS (m/e) No MI observed, Rt 1.17min (QC Method 2)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.