Reference of 1262417-94-6, These common heterocyclic compound, 1262417-94-6, name is Methyl 3-fluoro-6-iodo-2-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of methyl 3-fluoro-6-iodo-2-methylbenzoate i-lOb (0.5 g, 1.7 mmol) in dioxane (5 mL) were added 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi (1,3,2-dioxaborolane) (0.77g, 3.1 mmol), potassium acetate (217 mg, 2.21 mmol) and PdC12(dppf) (62 mg, 85 umol). The mixture was stirred at 100 C for 18 h under N2. The mixture was filtered and the filtrate was concentrated. The residue was purified by silica gel flash chromatography (1:100-1:20 EtOAc/hexanes) to give the title compound as a solid. ?H NMR (400 MHz, CDC13) oe 7.54-7.62 (m, 1H), 7.06 (t, J= 8.8 Hz, 1H), 3.89 (s, 3H), 2.26 (d, J 1.5 Hz, 3H), 1.32 (s, 12H).
The synthetic route of 1262417-94-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHANG, Hongjun; BARR, Kenneth, Jay; LAPOINTE, Blair, T.; GUNAYDIN, Hakan; LIU, Kun; TROTTER, B., Wesley; (67 pag.)WO2017/75185; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com