Category: 1232038-69-5

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators was written by Bischoff, Francois;Berthelot, Didier;De Cleyn, Michel;MacDonald, Gregor;Minne, Garrett;Oehlrich, Daniel;Pieters, Serge;Surkyn, Michel;Trabanco, Andres A.;Tresadern, Gary;Van Brandt, Sven;Velter, Ingrid;Zaja, Mirko;Borghys, Herman;Masungi, Chantal;Mercken, Marc;Gijsen, Harrie J. M.. And the article was included in Journal of Medicinal Chemistry in 2012.HPLC of Formula: 1232038-69-5 The following contents are mentioned in the article:

The design and the synthesis of several chem. subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of an aminopyridone into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo potency. This has resulted in the identification of benzimidazole I as a GSM with low nanomolar potency in vitro. In mouse, rat, and dog, this compound displayed the typical γ-secretase modulatory profile by lowering Aβ42 and Aβ40 levels combined with an especially pronounced increase in Aβ38 and Aβ37 levels while leaving the total levels of amyloid peptides unchanged. This study involved multiple reactions and reactants, such as 8-Bromo-3-iodoimidazo[1,2-a]pyridine (cas: 1232038-69-5HPLC of Formula: 1232038-69-5).

8-Bromo-3-iodoimidazo[1,2-a]pyridine (cas: 1232038-69-5) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 1232038-69-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase was written by Juillet, Charlotte;Ermolenko, Ludmila;Boyarskaya, Dina;Baratte, Blandine;Josselin, Beatrice;Nedev, Hristo;Bach, Stephane;Iorga, Bogdan I.;Bignon, Jerome;Ruchaud, Sandrine;Al-Mourabit, Ali. And the article was included in Journal of Medicinal Chemistry in 2021.Application In Synthesis of 8-Bromo-3-iodoimidazo[1,2-a]pyridine The following contents are mentioned in the article:

Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analog EL-228, whose structure could be optimized into the potent CJ2-150. Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biol. oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Mol. docking identified a probable binding mode in the allosteric site “F” and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action. This study involved multiple reactions and reactants, such as 8-Bromo-3-iodoimidazo[1,2-a]pyridine (cas: 1232038-69-5Application In Synthesis of 8-Bromo-3-iodoimidazo[1,2-a]pyridine).

8-Bromo-3-iodoimidazo[1,2-a]pyridine (cas: 1232038-69-5) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 8-Bromo-3-iodoimidazo[1,2-a]pyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com