Category: 1227270-32-7

Azaindole-1,2,3-triazole conjugate as selective fluorometric sensor for dihydrogen phosphate was written by Ghosh, Kumaresh;Kar, Debasis;Joardar, Soumen;Sahu, Debashis;Ganguly, Bishwajit. And the article was included in RSC Advances in 2013.Reference of 1227270-32-7 This article mentions the following:

A new receptor was designed and synthesized. The open cavity of triazole-pyrrolo[2,3-b]pyridine dimer selectively recognizes H₂PO₄^– over a series of other anions in CH₃CN containing 0.01% DMSO by exhibiting a ratiometric change in emission. In sensing, the cooperativity of the aza indoles in triazole-pyrrolo[2,3-b]pyridine dimer has been proved using a model compound Also the interaction behavior of the nitrogen in the azaindole has been proved by considering triazole-indole dimer, which did not show any discrimination towards the anions. Binding studies were carried out using fluorescence, UV-vis, ¹H-NMR and ³¹P-NMR spectroscopic techniques. The title compounds thus formed included a triazole aza-indole derivative (I) triazole-pyrrolo[2,3-b]pyridine dimer and related substances, such as triazole-indole dimer derivatives The synthesis of the target compound was achieved by a reaction of 1,3-bis(azidomethyl)benzene with (ethynyl)pyrrolo[2,3-b]pyridine. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Reference of 1227270-32-7).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Reference of 1227270-32-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed Amination of N-Free 2-Chloro-7-azaindole was written by Plas, Aurelie;Martin, Camille;Joubert, Nicolas;Viaud-Massuard, Marie-Claude. And the article was included in Organic Letters in 2015.Related Products of 1227270-32-7 This article mentions the following:

A simple and efficient procedure for the Pd-catalyzed amination of N-free 2-chloro-7-azaindole is described, using either primary or secondary amines. An optimized combination of Brettphos, a Brettphos precatalyst, and LiHMDS in THF led us to a novel methodol., applied to various functionalized amines to study the scope of the reaction. This is the first report of cross-coupling amination on N-free 2-chloro-7-azaindole to produce 2-amino 7-azaindoles I [R¹ = H, Et, Ph, etc; R² = Ph, 4-Me-C₆H₄, Bn, etc.]. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Related Products of 1227270-32-7).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Related Products of 1227270-32-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors was written by Baltus, Christine B.;Jorda, Radek;Marot, Christophe;Berka, Karel;Bazgier, Vaclav;Krystof, Vladimir;Prie, Gildas;Viaud-Massuard, Marie-Claude. And the article was included in European Journal of Medicinal Chemistry in 2016.Electric Literature of C7H5IN2 This article mentions the following:

From four mols., inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed a new series of tri-heterocyclic derivatives based on 1H-pyrrolo[2,3-b]pyridine (7-azaindole) and triazole heterocycles. Using a Huisgen type [3 + 2] cycloaddition as the convergent key step, 24 derivatives were synthesized and their biol. activities were evaluated. Comparative mol. field anal. (CoMFA), based on three-dimensional quant. structure-activity relationship (3D-QSAR) studies, was conducted on a series of 30 compounds from the literature with high to low known inhibitory activity towards CDK2/cyclin E and was validated by a test set of 5 compounds giving satisfactory predictive r² value of 0.92. Remarkably, it also gave a good prediction of pIC₅₀ for our tri-heterocyclic series which reinforce the validation of this model for the pIC₅₀ prediction of external set compounds The most promising compound, I, showed a micro-molar range inhibitory activity against CDK2/cyclin E and also an antiproliferative and proapoptotic activity against a panel of cancer cell lines. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Electric Literature of C7H5IN2).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Electric Literature of C7H5IN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com