Category: 1204518-02-4

C(sp³)-H Bond Arylation and Amidation of Si-Bound Methyl Group via Directing Group Strategy was written by Han, Jie-Lian;Qin, Ying;Zhao, Dongbing. And the article was included in ACS Catalysis in 2019.Synthetic Route of C17H18F3IO3S The following contents are mentioned in the article:

Silylmethyl functionalization provides a general and efficient access to diverse organosilanes. The traditional methods for silylmethyl functionalization often involved silylmethylmetals or silylmethyl halides. In recent years, a C-H activation strategy has become one of the most attractive alternatives in organic synthesis. Authors envisioned that the attachment of a coordinating group at silicon of methylsilanes provides the opportunity to modify the silylmethyl group via directed C-H bond functionalization. However, despite employment of silicon tethers bearing a directing group (DG) for C(sp²)-H functionalization has been well established due to the fact that the silicon tethers are easily installable and removable/modifiable, applying this concept toward C(sp³)-H functionalization remains underdeveloped. Herein, authors successfully developed Ir^III/Rh^III-catalyzed C-H bond arylation/amidation of silyl Me group by using directing group strategy, which constitutes the most powerful access to benzylsilanes and amino-substituted silanes. Moreover, they demonstrated that the pyridine directing group on silicon atom can be easily removed, and the starting materials can also be efficiently recovered, which are different from those of pyridine-directed C-H functionalization of C-bound Me group. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Synthetic Route of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Synthetic Route of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols was written by Calleja, Jonas;Pla, Daniel;Gorman, Timothy W.;Domingo, Victoriano;Haffemayer, Benjamin;Gaunt, Matthew J.. And the article was included in Nature Chemistry in 2015.Formula: C17H18F3IO3S The following contents are mentioned in the article:

Hemiaminals of β-amino alcs. such as I (R = H, Me) were regioselectively acetoxylated, arylated, cyclocarbonylated, and alkenylated (with subsequent Michael addition and reduction) in the presence of Pd(OAc)₂ to yield protected δ-functionalized-β-amino alcs. such as II (R = H, Me; R¹ = AcO, Ph, 4-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 4-EtO₂CC₆H₄, 4-MeC₆H₄, 4-MeOC₆H₄, 4-i-BuC₆H₄, 3-F₃CC₆H₄, 3-EtO₂CC₆H₄, 1,3-benzodioxol-5-yl), pyrrolooxazolidinones such as III, and pyrrolooxazolidines such as IV [R² = F₃CCH₂O₂C, 3,5-(F₃C)₂C₆H₃CH₂O₂C, PhSO₂]. The formation of sterically hindered hemiaminal moieties allowed the selective functionalization of amino alcs. by inhibiting the formation of inactive diaminepalladium complexes while allowing intramol. C-H activation to occur. The structure of an intermediate cyclopalladated spirocyclohexaneoxazoline was determined by X-ray crystallog. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Formula: C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Formula: C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Scalable electrochemical synthesis of diaryliodonium salts was written by Elsherbini, Mohamed;Moran, Wesley J.. And the article was included in Organic & Biomolecular Chemistry in 2021.Related Products of 1204518-02-4 The following contents are mentioned in the article:

Cyclic and acyclic diaryliodoniums I (R = H, 2-Me, 8-F, 6,8-(Me)₂, 7-CF₃; R¹ = 2-F, 7-Cl, 2-OMe, etc.) and II (R² = 4-F, 4-Br, 2-Ph, etc.; R³ = H, 4-I, 4-Me, 2,4,6-(Me)₃) are synthesized by anodic oxidation of iodobiaryls III and iodoarenes R²C₆H₄I/arene R³C₆H₅ mixtures, resp., in a simple undivided electrolysis cell in MeCN-HFIP-TfOH without any added electrolyte salts. This atom efficient process does not require chem. oxidants and generates no chem. waste. More than 30 cyclic and acyclic diaryliodonium salts I with different substitution patterns were prepared in very good to excellent yields. The reaction was scaled-up to 10 mmol scale giving more than four grams of dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate I (>95%) in less than three hours. The solvent mixture of the large-scale experiment was recovered (>97%) and recycled several times without significant reduction in yield. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Related Products of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Related Products of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com