Category: 1204518-02-4

Multicomponent alkene azidoarylation by anion-mediated dual catalysis was written by Bunescu, Ala;Abdelhamid, Yusra;Gaunt, Matthew J.. And the article was included in Nature (London, United Kingdom).HPLC of Formula: 1204518-02-4 The following contents are mentioned in the article:

The development of a dual catalysis platform that enabled a multicomponent coupling of alkenes, aryl electrophiles and a simple nitrogen nucleophile, providing single-step access to synthetically versatile and functionally diverse β-arylethylamines was reported. Driven by visible light, two discrete copper catalysts orchestrated aryl-radical formation and azido-group transfer, which underpin an alkene azidoarylation process. The process showed broad scope in alkene and aryl components and an azide anion performs a multifaceted role both as a nitrogen source and in mediating the redox-neutral dual catalysis via inner-sphere electron transfer. The synthetic capabilities of this anion-mediated alkene functionalization process are likely to be of use in a variety of pharmaceutically relevant and wider synthetic applications. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4HPLC of Formula: 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.HPLC of Formula: 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Trifluoromethylthiolation of Di(hetero)aryl-λ³-iodanes: Mechanistic Insight and Application to Synthesis of (Hetero)Aryl Trifluoromethyl Sulfides was written by Saravanan, Perumal;Anbarasan, Pazhamalai. And the article was included in Advanced Synthesis & Catalysis in 2015.Synthetic Route of C17H18F3IO3S The following contents are mentioned in the article:

The direct and regioselective copper/S-Phos-catalyzed trifluoromethylthiolation of sym. and unsym. di(hetero)aryl-λ³-iodanes has been accomplished for the synthesis of various (hetero)aryl trifluoromethyl sulfides employing readily accessible silver trifluoromethylthiolate (AgSCF₃) as nucleophilic trifluoromethylthiolating reagent. The developed transformation tolerates various functional groups like nitrile, enolizable ketone, ester, nitro and free carboxylic acid. Interestingly, the formal trifluoromethylthiolation of arenes was also achieved through integration of the synthesis of diaryl-λ³-iodanes from arenes with the trifluoromethylthiolation. Mechanistic investigations did not favor the radical formation and SET pathway. Based on the variable temperature ¹⁹F NMR spectroscopy, isolation of the most relevant catalytic intermediate, and stoichiometric studies supported the Cu(I)/Cu(III) catalytic cycle, wherein the oxidative addition of diaryl-λ³-iodanes was assisted by the silver salt. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Synthetic Route of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Efficient N-arylation of azole compounds utilizing selective aryl-transfer TMP-iodonium(III) reagents was written by Koseki, Daichi;Aoto, Erika;Shoji, Toshitaka;Watanabe, Kazuma;In, Yasuko;Kita, Yasuyuki;Dohi, Toshifumi. And the article was included in Tetrahedron Letters in 2019.Product Details of 1204518-02-4 The following contents are mentioned in the article:

It was determined that diaryliodonium(III) triflates bearing a trimethoxybenzene (TMP) auxiliary 2,4,6-(OCH₃)₃C₆H₂I⁺Ar-OTf^– (Ar = Ph, 4-methylphenyl, 4-methoxyphenyl, 2-chlorophenyl, thiophene-3-yl) are more reactive than the reported selective aryl-transfer iodonium salts in the N-arylation of benzimidazoles I (R = H, 5-NO₂, 6-Me, 5-OMe, 5-C(O)OMe) and other types of azole compounds such as 1H-imidazole, 2-methyl-1H-imidazole and 1H-pyrazole under catalytic conditions. The TMP-iodonium(III) salts can thus effectively facilitate the reaction at 50 °C or below, producing the corresponding N-arylated biaryls, e.g., II without the formation of TMP-derived coupling byproducts. Utilization of this TMP reagent under mild conditions would prevent the underlying problem of participation of the auxiliary group in the coupling reactions, which are observed while using the iodonium(III) salts that require elevated temperatures This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Product Details of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed redox cascade for direct β-arylation of ketones was written by Huang, Zhongxing;Dong, Guangbin. And the article was included in Tetrahedron in 2018.Electric Literature of C17H18F3IO3S The following contents are mentioned in the article:

A full article about the detailed design and development of two palladium-catalyzed redox cascade methods that enable direct β-arylation of ketones was reported. Palladium-catalyzed ketone dehydrogenation, aryl-X bond activation and conjugate addition were merged into a redox-neutral catalytic cycle. Non-metal-based aryl electrophiles were used as both the oxidant and the aryl source. The β-arylation with aryl iodides was achieved site-selectively with Pd(TFA)₂/P(i-Pr)₃ as the precatalyst and AgTFA as the iodide scavenger. Both cyclic and linear ketones were reacted to give β-aryl ketones with excellent functional group tolerance. The β-arylation with diaryliodonium salts was realized without stoichiometric heavy metal additives, and proved to be redox-neutral. A wider substrate scope regarding aryl groups and ketones was obtained for the arylation with diaryliodonium salts, and the possible involvement of palladium nanoparticles as the active catalyst was examined and discussed. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Electric Literature of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Electric Literature of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recyclable synthesis of mesityl iodonium(III) salts was written by Dohi, Toshifumi;Hayashi, Takumi;Ueda, Shohei;Shoji, Toshitaka;Komiyama, Keina;Takeuchi, Hitoshi;Kita, Yasuyuki. And the article was included in Tetrahedron in 2019.Electric Literature of C17H18F3IO3S The following contents are mentioned in the article:

An efficient protocol for C-H condensation of hypervalent iodine compounds with arenes in fluoroalcs. was applied to the recyclable preparation of mesityl iodonium(III) salts. The electrophilicities of [hydroxy(tosyloxy)iodo]mesitylene [MesI(OH)OTs] and iodomesitylene diacetate [MesI(OAc)₂] were suitably enhanced in 2,2,2-trifluoroethanol. A series of nucleophilic aromatic compounds reacted smoothly with MesI(OH)OTs and MesI(OAc)₂ or in-situ hypervalent iodine(III) species, generated from iodomesitylene, to provide the target mesityl iodonium(III) salts in good yields at room temperature with broad functional group tolerance. This C-H condensation strategy merits high para-regioselectivities during the diaryliodonium(III) salt formation, but the major limitation in the case of low-reactive aromatic substrates is byproduct formation resulting from the self-condensation of the nucleophilic mesitylene ring in MesI(OH)OTs and MesI(OAc)₂. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Electric Literature of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tandem Arylation/Friedel-Crafts Reaction of O-Hydroxy Bisbenzylic Alcohols with Diaryliodonium Salts: One Pot Synthesis of Unsymmetrical 9-Arylxanthenes was written by Mao, Song;Hua, Zerui;Wu, Xunshen;Yang, Yang;Han, Jianwei;Wang, Limin. And the article was included in ChemistrySelect in 2016.Product Details of 1204518-02-4 The following contents are mentioned in the article:

A one-pot synthesis of 9-arylxanthenes I (R¹ = H, 2-Br, 4-t-Bu, 4-Me, 1,4-Me₂, etc., R² = H, R³ = Ph, 2-MeOC₆H₄, 4-FC₆H₄, 1-naphthyl, etc.; R¹ = H, R² = 2-F, 2-F₃C, 2-EtO₂C, etc.; R³ = Ph) from easily prepared o-hydroxy bisbenzylic alcs. II and diaryliodonium salts III (R⁴ = R², 2,4,6-Me₃) is reported. O-Hydroxy bisbenzylic alcs. were utilized to generate carbinols in-situ with diaryliodonium salts promoted by base. Carbinols were then subjected to Bronsted acid catalyzed cyclization to furnish 9-arylxanthenes. A variety of sym. and unsym. 9-aryxanthenes were prepared assisted by base and Bronsted acid under mild conditions in satisfactory yields (up to 95%). Furthermore, the procedure was capable of tolerating a wide range of substrates. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Product Details of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Product Details of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iridium(III)-Catalyzed Direct Arylation of C-H Bonds with Diaryliodonium Salts was written by Gao, Pan;Guo, Wei;Xue, Jingjing;Zhao, Yue;Yuan, Yu;Xia, Yuanzhi;Shi, Zhuangzhi. And the article was included in Journal of the American Chemical Society in 2015.Synthetic Route of C17H18F3IO3S The following contents are mentioned in the article:

By developing a new Ir(III)-catalyzed C-C cross-coupling, a versatile method for direct arylation of sp² and sp³ C-H bonds in ketoximes, nitrogen-containing heterocycles, various arenes, and olefins has been established. The key to this arylation depends on the appropriate choice of catalyst and the use of diaryliodonium triflate salts as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C-H arylation of complex compounds Mechanistic studies by d. functional theory calculations suggested that the sp³ C-H activation was realized by a triflate-involved concerted metalation-deprotonation process, and the following oxidation of Ir(III) to Ir(V) is the most favorable when a bistriflimide is contained in the diaryliodonium salt. Calculations indicated that both steps are enabled by initial anion exchange between the reactant complexes. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Synthetic Route of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iridium(III)-Catalyzed Diarylation/Annulation of Benzoic Acids: Facile Access to Multi-Aryl Spirobifluorenes as Pure Hydrocarbon Hosts for High-Performance OLEDs was written by Luo, Yuanyuan;Liu, Zheng;Yang, Ge;Wang, Tianhong;Bin, Zhengyang;Lan, Jingbo;Wu, Di;You, Jingsong. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 1204518-02-4 The following contents are mentioned in the article:

Herein disclosed is the 1st example of diarylation/annulation of benzoic acids via an Ir catalyst system. This protocol provides a step-economic and highly efficient pathway to 1-aryl, 1,3-diaryl, 1,7-diaryl and 1,3,7-triaryl spirobifluorenes from readily available starting materials. The applications of multi-aryl spirobifluorenes as pure hydrocarbon (PHC) hosts for red, green, and blue (RGB) phosphorescent organic light-emitting diodes (PhOLEDs) were explored. Due to high triplet energies, 1,3-diaryl spirobifluorenes exhibit the potential as the host material of blue PhOLEDs. 1,7-Diaryl spirobifluorene can serve as the host of green PhOLEDs. 1,3,7-Triaryl spirobifluorene is a high-performance host for red PhOLEDs, which exhibits a high external quantum efficiency (EQE) up to 27.3%. This work not only exemplifies the great potential of multi-aryl spirobifluorenes as PHC hosts, but also offers a new approach for the synthesis of these PHC hosts. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Product Details of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Product Details of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System was written by Escudero-Casao, Margarita;Licini, Giulia;Orlandi, Manuel. And the article was included in Journal of the American Chemical Society in 2021.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides I (Ar = 3,4,5-trimethoxyphenyl) is described. This allows the arylation of silyl enol ethers (Z)-R¹C(OX)=CHR² (R¹ = MeO, Bu, Ph, 4-methoxy-3,5-dimethylphenyl, etc.; R² = Me, Et, benzyl; X = trimethylsilyl) to access enolizable α-arylated ketones R¹CH(R²)C(O)R³ (R³ = Ph, 2,3-dihydro-1H-inden-5-yl, 2-naphthyl, etc.) and II (Y = CH₂, O) in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation anal. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed direct β-arylation of ketones with diaryliodonium salts: a stoichiometric heavy metal-free and user-friendly approach was written by Huang, Zhongxing;Sam, Quynh P.;Dong, Guangbin. And the article was included in Chemical Science in 2015.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A new protocol for the Pd-catalyzed β-arylation of ketones such as cyclohexanone, cyclopentanone, cycloheptanone, etc. without stoichiometric heavy metals has been reported. Widely accessible mesitylaryliodonium salts I (Ar = C₆H₅, naphth-1-yl, 2,5-dimethylthiophen-3-yl, biphenyl-4-yl, etc.) are used as both the oxidant and aryl source. This tandem redox catalysis merges ketone dehydrogenation and conjugate addition without an addnl. oxidant or reductant. This transformation features the use of a unique bis-N-tosylsulfilimine ligand and the combination of potassium trifluoroacetate/trifluoroacetic acid to maintain an appropriate acidity of the reaction medium. The reaction tolerates both air and moisture, and shows a broad substrate scope. Kinetics studies, along with filtration and poisoning tests, support the involvement of palladium nanoparticles in the catalysis. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com