In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1150617-63-2 as follows. COA of Formula: C7H7ClIN
To a solution of 5-chloro-2-iodo-3-methylaniline (325 mg, 1.21 mmol), PEPPSI-IPr (50.5 mg, 0.0729 mmol) and sodium tert-butoxide (193 mg, 1.94 mmol) in toluene (4 mL) is added 2-bromopropene (0.136 mL, 1.52 mmol). The mixture is heated at 175C for 15 min in the microwave, then at 215C for 20 min. The RM is concentrated under reduced pressure, and purified by FC, eluting with heptane/DCM 1 :0 to 3:1. This afforded the title compound as a yellow solid (71 mg, 33%). LC-MS A: tR = 0.89 min; [M+H]+ = 180.29. A.1.60. 6-Chloro-N-(2-(5,7-difluoro-2,4-dimethyl-1H-indol-1-yl)ethyl)pyrimidin-4-amine The title compound is prepared according to the synthesis of A.1.1. described above using 2-(5,7-difluoro-2,4- dimethyl-1 H-indol-1-yl)ethan-1-amine; LC-MS A: tR = 0.94 min; [M+H]+ = 336.96.
According to the analysis of related databases, 1150617-63-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; FRETZ, Heinz; LYOTHIER, Isabelle; POTHIER, Julien; RICHARD-BILDSTEIN, Sylvia; SIFFERLEN, Thierry; WYDER PETERS, Lorenza; POZZI, Davide; CORMINBOEUF, Olivier; (306 pag.)WO2017/85198; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com