Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1147014-97-8, name is 5-Bromo-2-iodoisopropylbenzene, A new synthetic method of this compound is introduced below., Product Details of 1147014-97-8
A mixture of 14 (182 mg, 0.85 mmol), 31 (182 mg, 0.56 mmol), Pd(PPh3)4Cl2 (40 mg, 0.06 mmol), and IM TBAF in TetaF (3.5 mL, 3.5 mmol) was irradiated in the microwave at 160 0C for 15 min. The solids were filtered, the filtrate was concentrated in vacuo, and the residue purified by etaPLC. The fractions were neutralized with sat NaHCO3 and extracted with EtOAc. The organic layers were concentrated in vacuo to afford the title compound as a yellow-brown solid (30 mg, 16%).[0259] 1H NMR (500 MHz, DMSO-J6) delta 1.32 (d, J= 6.9 Hz, 6H), 3.53 (qn, J= 6.8 Hz, IH), 6.66 (d, J = 3.4 Hz, IH), 7.53 (dd, J = 8.3, 1.7 Hz, IH), 7.62-7.67 (m, 2H), 7.71 (d, J = 3.4 Hz, IH), 8.77 (s, IH)[0260] MS (ES+): m/z 340/342 (M+H)+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com