Category: 112671-42-8

112671-42-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In the round bottom flask, the benzo [b] thiophene-3- base boric acid (benzo[b]thiophen-3-ylboronicacid) 65.1g, 4-bromo-1-iodo-2-nitrobenzene (4-bromo-1-iodo-2-nitrobenzene) 100g dissolving in toluene 1600 ml and adding K2CO3(2M) 455 ml and Pd (PPh3)4(four (triphenylphosphine) palladium) 10.5g of the backflow after stirring. In TLC (thinlayerchromatography, thin layer chromatography) confirmed the reaction and the reaction is terminated after addition of water. The organic layer using EA and extraction (ethanol) of the pressure-reducing filter after the column to purify 84.5g intermediate 4′ -1 (the yield is 83%).

The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xian, hao wan; an, xianzhe; han, zheng you; jin, jin tai; li, ying zhen; (67 pag.)CN105473594; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 112671-42-8

(3) Add (100mmol) M2 to the reaction flask32.6g (100mmol) of 2-iodo-5-bromonitrobenzene,(1%) Pd (PPh3) 4,40g (300mmol) sodium carbonate,Toluene (800mL), ethanol (200mL)And water (200mL),Heated to reflux, reacted for 8h, the reaction was completed;The reaction solution was extracted with ethyl acetate, and the organic phase was concentrated.A yellow solid M3 was obtained;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112671-42-8, its application will become more common.

Reference:
Patent; Yantai Xianhua Chemical Technology Co., Ltd.; Xing Qifeng; Feng Peichuan; Chen Yue; Hu Lingfeng; Chen Yili; (28 pag.)CN110698458; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com